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Post a Comment The effect of neuropeptide ACTH4-10 on the adaptation of patients to dental prostheses according to the data of monitoring the emotional state using a polygraph
- Authors: Pozhilova E.V.1, Novikov V.E.1, Evseev A.V.1, Abolmasov N.N.1
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Affiliations:
- Smolensk State Medical University
- Issue: Vol 20, No 3 (2022)
- Pages: 309-316
- Section: Original study articles
- URL: https://journal-vniispk.ru/RCF/article/view/112457
- DOI: https://doi.org/10.17816/RCF203309-316
- ID: 112457
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Abstract
BACKGROUND: Monitoring and pharmacological correction of adaptation of patients to full removable dental prostheses is actual and practically important problem in stomatology.
AIM: To study the effect of neuropeptide ACTH4-10 on the process of adaptation of patients to complete removable prostheses by monitoring the emotional state using a polygraph.
MATERIALS AND METHODS: Examination and primary prosthetics with full removable dentures of patients (60–75 years old) were performed of both sexes with total adentia. All patients were divided into three groups: the main group (correction of the adaptation process with ACTH4-10 neuropeptide — Semax 0.1% nasal drops), the comparison group (0.9% NaCl solution was administered intranasally) and the control group (without pharmacological correction). Monitoring of the process of adaptation to prostheses was carried out by registering the emotional reaction of patients to the movements of the lower jaw with the help of a polygraph “Barrier-14” of the company “Antey” (Russia).
RESULTS: The emotional state of patients in the main observation group who received pharmacological correction with ACTH4-10 neuropeptide reaches the values of adapted patients for most of the studied indicators within 7–14 days after the application of prostheses, and a month after the application of prostheses - for all studied indicators of the curves of the trajectories of the lower jaw (p > 0.05), which cannot be noted in patients of the comparison group (NaCl) and the control group. The results obtained indicate a positive effect of the neuropeptide ACTH4-10 on the process of getting used to patients with complete removable prostheses.
CONCLUSIONS: Neuropeptide ACTH4-10 accelerates the process of adaptation of primary prosthetic patients to complete removable dental prostheses according to the monitoring of the emotional background of patients. The method of registering the emotional state of patients using a polygraph allows us to make an objective conclusion about the effect of occlusion and articulation on the psycho-emotional background and judge the patient's adaptation to a dental prosthesis.
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##article.viewOnOriginalSite##About the authors
Elena V. Pozhilova
Smolensk State Medical University
Author for correspondence.
Email: elena-pozh2008@yandex.ru
ORCID iD: 0000-0002-7372-7329
SPIN-code: 6371-6930
Assistant of the Department of Orthopedic Dentistry with a course of orthodontics
Russian Federation, 28, Krupskaya str., Smolensk, 214019Vasiliy E. Novikov
Smolensk State Medical University
Email: nau@sgmu.info
ORCID iD: 0000-0002-0953-7993
SPIN-code: 1685-1028
Dr. Sci. (Med.), Professor, Head of the Department of Pharmacology
Russian Federation, 28, Krupskaya str., Smolensk, 214019Andrey V. Evseev
Smolensk State Medical University
Email: hypoxia@yandex.ru
ORCID iD: 0000-0001-7296-8502
SPIN-code: 9095-8712
Dr. Sci. (Med.), Professor, Head of the Department of Normal Physiology
Russian Federation, 28, Krupskaya str., Smolensk, 214019Nikolay N. Abolmasov
Smolensk State Medical University
Email: ortos-sgma@mail.ru
ORCID iD: 0000-0002-1676-0501
SPIN-code: 4306-7935
Dr. Sci. (Med.), Professor, Head of the Department of Orthopedic Dentistry with a course of orthodontics
Russian Federation, 28, Krupskaya str., Smolensk, 214019References
- Studenikin RV, Surzhenko EV, Yelkova NL. Assessment of the quality of life of patients with complete loss of teeth with various methods of orthopedic treatment. Institute of Dentistry. 2018;(1): 30–31. (In Russ.)
- Pozhilova EV, Evseeva OA, Novikov VE, Evseev AV. Adaptation factors to dentures and possibility of pharmacological regulation. Vestnik of the Smolensk State Medical Academy. 2016;15(3): 101–108. (In Russ.)
- Markskors R. S''emnye stomatologicheskie restavratsii. Moscow: News Agency Newdet; 2006. 312 p. (In Russ.)
- Patent RU № 2533840/24.09.2014. Urakov AL, Urakova NA, Reshetnikov AP, at al. Artificial food bolus and method forinstant assessment of dento-facial health with using artificial food bolus. (In Russ.) Available from: https://rusneb.ru/catalog/000224_000128_0002533840_20141120_C2_RU/
- Turgeneva LB, Novikov VE, Pozhilova EV. Lechenie vospalitel’nykh zabolevanii parodonta meksidolom. Pathogenesis. 2011;9(3):67. (In Russ.)
- Novikov VE, Ilyukhin SA, Pozhilova EV. Influence of metaprot and hypoxen on the inflammatory reaction development in the experiment. Reviews of Clinical Pharmacology and Drug Therapy. 2012;10(4):63–66. (In Russ.)
- Novikov VE, Ilyukhin SA. The effect of hypoxene on the effectiveness of acetylsalicylic acid in acute inflammation Influence of hypoxen on acetylsalicylic acid efficiency in acute inflammation. Experimental and Clinical Pharmacology. 2013;14(1):32–35. (In Russ.)
- Levchenkova OS, Novikov VE. Antihypoxants: possible mechanisms of action and their clinical uses. Vestnik of the Smolensk State Medical Academy. 2011;10(4):43–57. (In Russ.)
- Levchenkova OS, Novikov VE. Possibilities of pharmacological preconditioning. Vestnik of the Russian Academy of Medical Sciences. 2016;21(1):16–24. (In Russ.) doi: 10.15690/vramn626
- Novikov VE, Levchenkova OS, Pozhilova EV. Role of mitochondrial ATP-dependent potassium channel and its modulators in cell adaptation to hypoxia. Vestnik of the Smolensk State Medical Academy. 2014;13(2):48–54. (In Russ.)
- Levchenkova OS, Novikov VE, Pozhilova EV. Mitochondrial pore as a pharmacological target. Vestnik of the Smolensk State Medical Academy. 2014;13(4):24–33. (In Russ.)
- Pozhilova EV, Novikov VE, Levchenkova OS. The mitochondrial ATP-dependent potassium channel and its pharmacological modulators. Reviews on Clinical Pharmacology and Drug Therapy. 2016;14(1):29–36. (In Russ.) doi: 10.17816/RCF14129-36
- Novikov VE, Levchenkova OS, Pozhilova EV. Mitochondrial nitric oxide synthase and its role in the mechanisms of cell adaptation to hypoxia. Reviews on Clinical Pharmacology and Drug Therapy. 2016;14(2):38–46. (In Russ.) doi: 10.17816/RCF14238-46
- Pozhilova EV, Novikov VE, Urakov AL. The possibilities of pharmacological regulation of the processes of adaptation to dental constructions. Reviews on Clinical Pharmacology and Drug Therapy. 2017;15(2):12–22. (In Russ.) doi: 10.17816/RCF15212-22
- Pozhilova EV, Novikov VE. Pharmacodynamics and clinical application of ACTH4–10 neuropeptide. Vestnik of the Smolensk State Medical Academy. 2020;19(3):76–86. (In Russ.) doi: 10.37903/vsgma.2020.3.10
- Patent RU2652749/28.04.2018. Evseev AV, Shashmurina VR, Pravdivtsev VA, et al. Method for recording activity of masticatory muscles of the maxillofacial system. Available from: https://rusneb.ru/catalog/000224_000128_0002652749_20180428_C1_RU/ (In Russ.)
- Pozhilova EV, Abolmasov NN, Novikov VE, Derevtsova SN. Pharmacodynamics and clinical application of ACTH4–10 neuropeptide. Vestnik of the Smolensk State Medical Academy. 2022;21(1):17–25. (In Russ.)
