Idealization in pharmacology and pharmacy: Symbol of the chemical formula of one molecule of a substance and a real pharmaceutical product

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Abstract

The essence of the two levels of information used in modern pharmacy, pharmacology, and medicine for operations related to theoretical reasoning about medicines and the actual practice of their use for treating specific cases is fundamentally different. In particular, studies have analyzed the essence of theoretical information about medicines and the norms of their use in accordance with medical care standards. Information about medicines and standards of medical care, which dominate textbooks, reference books, encyclopedias, scientific articles , and normative and technical documents, is built on the idealized essence of chemically pure substances and their interaction with an idealized virtual patient. Accordingly, in the fields of pharmacy, pharmacology, and chemistry, physics, and materials science, researchers have traditionally represented chemical elements (and drugs) by certain chemical formulas, names, and symbols for their molecules. Moreover, in pharmacy and pharmacology, the structural formula of one molecule of only one chemical substance belonging to the group of the so-called main active substances most often plays this role. Generally, this chemical symbol of its molecule is identified with the real substance itself. It is assumed that the substance in question is of ideal high quality, is completely free of any impurities, is not combined with other substances, and does not represent a certain pharmaceutical product (it is not a tablet, not a solution, not an ointment, not an aerosol, etc.), and is not manufactured by a certain pharmaceutical company according to a certain recipe. Moreover, modern pharmaceutical products are not separate molecules, not pure chemical reagents, but all sorts of mixtures of different substances of different quality in different ratios. In addition, each pharmaceutical product of each manufacturing plant and each series number has inherent and unique mechanical, physical, chemical, and physicochemical properties and quality indicators. Therefore, the idealized essence of drugs is far from that of real pharmaceutical products. The chemical name and chemical formula are symbols of one molecule of a chemical element, reflecting its idealized chemical essence, but not the essence of a real “tablet”, “ampule”, and/or “tube” with it. In turn, the virtual patient of known sex, average age, average health status, and a body weight of approximately 70 kg implied by the standards of medical care is just an idealized object of interaction with an idealized “medicine”. In this regard, the study of the relationship between the idealized and real drugs and patients is a crucial part of the problem of the relationship between theory and reality in pharmacy, pharmacology, and medicine.

About the authors

Aleksandr L. Urakov

Izhevsk State Medical Academy

Author for correspondence.
Email: urakoval@live.ru
ORCID iD: 0000-0002-9829-9463
SPIN-code: 1613-9660

MD, Dr. Sci. (Medicine), Professor

Russian Federation, Izhevsk

Petr D. Shabanov

Institute of Experimental Medicine

Email: pdshabanov@mail.ru
ORCID iD: 0000-0003-1464-1127
SPIN-code: 8974-7477

Dr. Med. Sci. (Pharmacology), Professor

Russian Federation, Saint Petersburg

References

  1. Habermann ER. Rudolf Buchheim and the beginning of pharmacology as a science. Annual Review of Pharmacology. 2003;14(1):1–9. doi: 10.1146/annurev.pa.14.040174.000245
  2. Resnikov KM. Pharmacological vector of Rudolf Buchheim. Research Results in Pharmacology. 2019;5(1):103–116. doi: 10.3897/rrpharmacology.5.32234
  3. Lees P, Bäumer W, Toutain PL. The decline and fall of Materia Medica and the rise of pharmacology and therapeutics in veterinary medicine. Front Vet Sci. 2022;8:777809. doi: 10.3389/fvets.2021.777809
  4. Simon D. Chemistry and pharmacy: a philosophical inquiry into an evolving relationship. In: Woody AI, Findlay Hendry R, Needham P., editors. Philosophy of chemistry. Handbook of the philosophy of science. Vol. 6. North-Holland; 2012. P. 519–530. doi: 10.1016/B978-0-444-51675-6.50033-5
  5. Zhang W, Huai Y, Miao Z, et al. Systems pharmacology for investigation of the mechanisms of action of traditional Chinese medicine in drug discovery. Front Pharmacol. 2019;10:743. doi: 10.3389/fphar.2019.00743
  6. Nagoor Meeran MF, Javed H, Al Taee H, et al. Pharmacological properties and molecular mechanisms of thymol: Prospects for its therapeutic potential and pharmaceutical development. Front Pharmacol. 2017;8:380. doi: 10.3389/fphar.2017.00380
  7. Barsu C. History of Medicine between tradition and modernity. Clujul Medical. 2017;90(2):243–245. doi: 10.15386/CJMED-794
  8. Scerri ER. Chapter: philosophy of chemistry, reduction, emergence, and chemical education. In: Ellison M, Schoolcraft T, editors. Advances in teaching physical chemistry. Publisher: American Chemical Society. 2008. P. 59–72. doi: 10.1021/bk-2008-0973
  9. Fernández-González M. Idealization in сhemistry: Pure substance and laboratory product. Sci & Educ. 2013;22:1723–1740. doi: 10.1007/s11191-011-9428-2
  10. Urakov AL. Gases as ingredients of medicines. Reviews on Clinical Pharmacology and Drug Therapy. 2020;18(4):351–358. doi: 10.17816/RCF184351-358
  11. Urakov AL, Shabanov PD, Gurevich KG, Lovtsova LV. Supplementing traditional drug formulation with the “needed” gases opens the way for the development of a new generation of drugs. Psychopharmacology & Biological Narcology. 2023;14(1):5–14. doi: 10.17816/phbn321616
  12. Yuan H, Ma Q, Ye L, Piao G. The traditional medicine and modern medicine from natural products. Molecules. 2016;21(5):559. doi: 10.3390/molecules21050559
  13. Park SY, Kim KS, Lee WY, Kim CE, Lee S. Integrative approach to identifying system-level mechanisms of Chung-Sang-Bo-Ha-Hwan’s influence on respiratory tract diseases: A network pharmacological analysis with experimental validation. Plants (Basel). 2023;12(17):3024. doi: 10.3390/plants12173024
  14. Erduran S. Philosophy of chemistry: an emerging field with implications for chemistry education. Sci Educ. 2001;10:581–593. doi: 10.1023/A:1017564604949
  15. Erduran S. Applying the philosophical concept of reduction to the chemistry of water: Implications for chemical education. Sci Educ. 2005;14:161–171. doi: 10.1007/s11191-005-0687-7
  16. Erduran S, Aduriz-Bravo A, Naaman R. Developing epistemologically empowered teachers: Examining the role of philosophy of chemistry in teacher education. Sci Educ. 2007;16:975–989. doi: 10.1007/s11191-006-9072-4
  17. Urakov AL, Dementyev VB, Urakova NA, et al. Clinical significance of physical-chemical processes determining qualitative and quantitative characteristics of post-injection diffusion of drug solutions in patient’s soft tissues. Himicheskaja Fizika i Mezoskopija. 2007;9(2):105–111.
  18. Urakov AL, Urakova NA, Kozlova TS. Local toxicity of medicines as the indicator of their probable aggression at local application. Journal of Ural Medical Academic Science. 2011;1(33):105–108.
  19. Urakov A, Urakova N. Rheology and physical-chemical characteristics of the solutions of the medicines. J Phys Conf Ser. 2015;602:012043. doi: 10.1088/1742-6596/602/1/012043
  20. Urakov AL. The change of physical-chemical factors of the local interaction with the human body as the basis for the creation of materials with new properties. Epitőanyag — JSBCM. 2015;67(1):2–6. doi: 10.14382/epitoanyag-jsbcm.2015.1
  21. Drews J. Drug discovery: a historical perspective. Science. 2000;287(5460):1960–1964. doi: 10.1126/science.287.5460.1960
  22. Taylor D. The pharmaceutical industry and the future of drug development. Pharmaceuticals in the Environment. 2016;1:1–33. doi: 10.1039/9781782622345-00001
  23. Urakov AL, Shabanov PD. Physical-chemical repurposing of drugs. History of its formation in Russia. Reviews on Clinical Pharmacology and Drug Therapy. 2023;21(3):231–242. doi: 10.17816/RCF567782
  24. De Vos P. European materia medica in historical texts: longevity of a tradition and implications for future use. J Ethnopharmacol. 2010;132:28–47. doi: 10.1016/j.jep.2010.05.035
  25. Dun F. Veterinary medicines, their actions and uses. 12th ed. Edinburgh: David Douglas; 1910. 820 p.
  26. Toomsalu M. Rudolf Richard Buchheim, the founder of pharmacology. Naunyn Schmiedebergs Arch Pharmacol. 2023;396(11): 2793–2811. doi: 10.1007/s00210-023-02528-z
  27. Jones AW. Early drug discovery and the rise of pharmaceutical chemistry. Drug Test Anal. 2011;3(6):337–344. doi: 10.1002/dta.301
  28. Montinari MR, Minelli S, De Caterina R. The first 3500 years of aspirin history from its roots — A concise summary. Vascul Pharmacol. 2019;113:1–8. doi: 10.1016/j.vph.2018.10.008
  29. Jones LM. Veterinary Pharmacology and Therapeutics, 1st edition. Ames, IA: The Iowa State College Press; 1953. 850 p.
  30. Alelaimat MA, Al-Sha’er MA, Basheer HA. Novel sulfonamide-triazine hybrid derivatives: Docking, synthesis, and biological evaluation as anticancer agents. ACS Omega. 2023;8(15):14247–14263. doi: 10.1021/acsomega.3c01273
  31. Eder J, Sedrani R, Wiesmann C. The discovery of first-in-class drugs: origins and evolution. Nat Rev Drug Discov. 2014;13(8): 577–587. doi: 10.1038/nrd4336
  32. Swinney DC, Anthony J. How were new medicines discovered? Nat Rev Drug Discov. 2011;10(7):507–519. doi: 10.1038/nrd3480
  33. Bustamante C, Ochoa R, Asela C, Muskus C. Repurposing of known drugs for leishmaniasis treatment using bioinformatic predictions, in vitro validations and pharmacokinetic simulations. J Comput Aided Mol Des. 2019;33(9):845–854. doi: 10.1007/s10822-019-00230-y
  34. Suppe F. The semantic conception of theories and scientific realism. Urbana: University of Illinois press. 1989. 475 p.
  35. Urakov AL. Development of new materials and structures based on managed physical-chemical factors of local interaction. IOP Conf Ser Mater Sci Eng. 2016;123:012008. doi: 10.1088/1757-899X/123/1/012008
  36. Urakov A, Urakova N, Reshetnikov A, et al. Reprofiling hydrogen peroxide from antiseptics to pyolytics: A narrative overview of the history of inventions in Russia. Journal of Pharmaceutical Research International. 2023;35(6):37–48. doi: 10.9734/jpri/2023/v35i67333
  37. Urakov A, Urakova N, Sorokina Yu, et al. Targeted modification of physical-chemical properties of drugs as a universal way to transform “old” drugs into “new” drugs. In: Dr. Mithun Rudrapal, ed. Drug Repurposing — Advances, Scopes and Opportunities in Drug Discovery. Chapter 3. IntechOpen; 2023. doi: 10.5772/intechopen.110480
  38. Urakov AL. Medicines in pharmaceutical form “solution for injection” and the injection of drugs: advantages and limitations. Reviews on Clinical Pharmacology and Drug Therapy. 2019;17(2): 79–84. doi: 10.17816/RCF17279-84
  39. Shabanov PD, Fisher EL, Urakov AL. Hydrogen peroxide formulations and methods of their use for blood oxygen saturation. Journal of Medical Pharmaceutical and Allied Science. 2022;11(6):5489–5493. doi: 10.55522/jmpas.V11I6.4604
  40. Urakov A, Sokolova V, Samorodov A. Perspective Chapter: Clinical standard of a geriatric patient as a virtual target for correction of pharmacotherapy of hypertension and stroke in the elderly. Rijeka: IntechOpen; 2023. doi: 10.5772/intechopen.110671

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