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Post a Comment Antidepressant effect of new coumarin derivatives
- Authors: Daliev B.B.1, Klimenko D.I.1, Karpova I.V.1, Myznikov L.V.1, Bychkov E.R.1, Lebedev A.A.1, Shabanov P.D.1
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Affiliations:
- Institute of Experimental Medicine
- Issue: Vol 22, No 2 (2024)
- Pages: 163-170
- Section: Original study articles
- URL: https://journal-vniispk.ru/RCF/article/view/263143
- DOI: https://doi.org/10.17816/RCF623295
- ID: 263143
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Abstract
BACKGROUND: The incidence of bipolar disorder is increasing worldwide. The search for new compounds with antidepressant activity and milder adverse drug reactions is an urgent task of modern psychopharmacology.
AIM: This study aimed to analyze the effect of new neuroactive coumarin derivatives on the level of depressive behavior and monoamine metabolism in the brain structures of rats.
MATERIALS AND METHODS: The antidepressant effects of LVM-091, LVM-099, LVM-S144, and IEM-2886 were evaluated in rats subjected to the Porsolt forced swimming test and the metabolism of monoamines in brain structures (LVM-099) using high-performance liquid chromatography.
RESULTS: LVM-091, LVM-099, LVM-S144, and IEM-2886, synthesized from coumarin, decreased the immobilization time of the experimental rats in the Porsolt forced swimming test, indicating the antidepressant effect of these substances. The administration of LVM-099 at a dose of 10 mg/kg increased the level of homovanillic acid and the homovanillic acid-to-dopamine ratio in the nucleus accumbens. LVM-099 also increased 5-hydroxyindoleacetic acid levels and the 5-hydroxyindoleacetic acid-to-serotonin ratio in the nucleus accumbens. In the amygdala, the levels of norepinephrine, dopamine, serotonin, and their metabolites did not change after LVM-099 administration.
CONCLUSIONS: New coumarin derivatives exert antidepressant effects and increase the metabolism of dopamine and serotonin in rat nucleus accumbens, which can be used in the development of new highly effective antidepressants.
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##article.viewOnOriginalSite##About the authors
Bakhodir B. Daliev
Institute of Experimental Medicine
Author for correspondence.
Email: bahodirdaliev@gmail.com
ORCID iD: 0000-0001-5966-8783
Russian Federation, Saint Petersburg
Dmitrii I. Klimenko
Institute of Experimental Medicine
Email: dima.klimenko999@mail.ru
ORCID iD: 0009-0007-8168-7228
SPIN-code: 8481-4489
Russian Federation, Saint Petersburg
Inessa V. Karpova
Institute of Experimental Medicine
Email: inessa.karpova@gmail.com
ORCID iD: 0000-0001-8725-8095
SPIN-code: 9874-4082
Dr. Sci. (Biology), Assistant Professor
Russian Federation, Saint PetersburgLeonid V. Myznikov
Institute of Experimental Medicine
Email: myznikov_lv@mail.ru
ORCID iD: 0000-0002-0863-3027
Dr. Sci. (Chemistry), Assistant Professor
Russian Federation, Saint PetersburgEvgenii R. Bychkov
Institute of Experimental Medicine
Email: bychkov@mail.ru
ORCID iD: 0000-0002-8911-6805
SPIN-code: 9408-0799
Dr. Sci. (Medicine)
Russian Federation, Saint PetersburgAndrey A. Lebedev
Institute of Experimental Medicine
Email: aalebedev-iem@rambler.ru
ORCID iD: 0000-0003-0297-0425
SPIN-code: 4998-5204
Dr. Sci. (Biology)
Russian Federation, Saint PetersburgPetr D. Shabanov
Institute of Experimental Medicine
Email: pdshabanov@mail.ru
ORCID iD: 0000-0003-1464-1127
SPIN-code: 8974-7477
Dr. Sci. (Medicine), Professor
Russian Federation, Saint PetersburgReferences
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