Нейроповеденческие эффекты холинергических веществ в пренатальном периоде

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Экологические токсиканты, химические вещества, проявляющие холинотропные свойства, и лекарственные препараты — агонисты и антагонисты М- и Н-холинорецепторов, воздействуя на развивающийся мозг плода в эмбриональном периоде онтогенеза, вызывают изменение активности холинергических механизмов головного мозга в критические сроки пренатального развития с последующим нарушением формирования различных систем мозга, в первую очередь онтогенеза нервных клеток и нейромедиаторных систем мозга. Эти изменения в отдаленном периоде коррелируют с нейроповеденческими дефицитами у взрослых особей и дисфункцией репродуктивной системы у взрослого потомства. Актуальность исследования пренатальных эффектов холинергических факторов на центральные механизмы репродуктивной функции, процессы памяти и обучения в ходе онтогенетического развития организма обусловлена необходимостью профилактики и лечения последующих психических, поведенческих и половых дисфункций, аномального полового поведения, а также бесплодия.

Об авторах

Елена Владимировна Сташина

ФГБНУ «Институт экспериментальной медицины»

Автор, ответственный за переписку.
Email: lena-stashina@mail.ru

аспирант отдела нейрофармакологии им. С.В. Аничкова

Россия, 197376, г. Санкт-Петербург, ул. Академика Павлова, 12

Николай Алексеевич Гаврилов

ФГБНУ «Институт экспериментальной медицины»

Email: gavriloff71@mail.ru

аспирант отдела нейрофармакологии им. С.В. Аничкова

Россия, 197376, г. Санкт-Петербург, ул. Академика Павлова, 12

Петр Дмитриевич Шабанов

ФГБНУ «Институт экспериментальной медицины»; ФГБУ «Северо-Западный федеральный медицинский исследовательский центр им. В.А. Алмазова» Минздрава России

Email: pdshabanov@mail.ru

д-р мед. наук, профессор, заведующий отделом нейрофармакологии им. С.В. Аничкова ФГБНУ «Институт экспериментальной медицины»; ведущий научный сотрудник ФГБУ «Северо-Западный федеральный медицинский исследовательский центр им. В.А. Алмазова»

Россия, 197376, г. Санкт-Петербург, ул. Академика Павлова, 12; 197341, г. Санкт-Петербург, ул. Аккуратова, 2

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