Possibilities of pharmacological correction of reperfusion injury of ischemic myocardium (review)
- Authors: Gurevich K.G.1, Urakov A.L.2, Fisher E.L.2, Abzalilov T.A.3, Khairzamanova K.A.3, Yagudin T.A.3, Samorodov A.V.3
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Affiliations:
- A.I. Evdokimov Moscow State Medical and Dental University
- Izhevsk State Medical Academy
- Bashkir State Medical University
- Issue: Vol 19, No 3 (2021)
- Pages: 259-267
- Section: Reviews
- URL: https://journal-vniispk.ru/RCF/article/view/82804
- DOI: https://doi.org/10.17816/RCF193259-267
- ID: 82804
Cite item
Abstract
Timely and effective reperfusion in ischemia and reoxygenation in hypoxia of the heart muscle prevent myocardial infarction. Delayed reperfusion and reoxygenation in myocardial ischemia and hypoxia can cause reversible damage in it, which, with a favorable outcome, disappear without a trace. Excessively late reperfusion and reoxygenation inevitably ends with irreversible damage to the myocardium, which is widely known as a myocardial infarction, and which, together with other complications of cardiac ischemia, can cause disability and death of the patient. In recent years, reperfusion injury of the ischemic heart muscle has been recognized as an independent link in the pathogenesis of myocardial infarction. The mechanisms of this link of pathogenesis have been partially studied in experimental conditions. The phenomena of preconditioning and post-conditioning have been discovered, the effects of which are currently determined fairly reliably. After determining the mechanisms of reperfusion injury of the ischemic myocardium, the search and development of pharmacological agents capable of inducing such a phenomenon as cardioprotection began. In parallel, studies of specific microRNAs that claim to be diagnostic markers are being conducted, as well as the search for drugs that affect the level of their expression is being conducted. The information about the achieved successes in this direction is given.
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##article.viewOnOriginalSite##About the authors
Konstantin G. Gurevich
A.I. Evdokimov Moscow State Medical and Dental University
Author for correspondence.
Email: kgurevich@mail.ru
ORCID iD: 0000-0002-7603-6064
SPIN-code: 4344-3045
MD, Dr. Sci. (Med.), Professor
Russian Federation, 20, p. 1, Delegatskaya str., Moscow, 127473Aleksandr L. Urakov
Izhevsk State Medical Academy
Email: urakoval@live.ru
ORCID iD: 0000-0002-9829-9463
SPIN-code: 1613-9660
MD, Dr. Sci. (Med.), Professor
Russian Federation, 281, st. Kommunarov, Udmurt Republic, Izhevsk, 426034Eugeniy L. Fisher
Izhevsk State Medical Academy
Email: elfischer@mail.ru
SPIN-code: 6102-5539
doctor, postgraduate student
Russian Federation, 281, st. Kommunarov, Udmurt Republic, Izhevsk, 426034Timer A. Abzalilov
Bashkir State Medical University
Email: timer_abzalilov@mail.ru
ORCID iD: 0000-0002-7044-2117
SPIN-code: 2539-9411
assistant professor
Russian Federation, 3, Lenina str., Ufa, 450008Kseniya A. Khairzamanova
Bashkir State Medical University
Email: kzavadich@mail.ru
ORCID iD: 0000-0002-4792-7132
SPIN-code: 6489-9598
Cand. Sci. (Med.)
Russian Federation, 3, Lenina str., Ufa, 450008Timur A. Yagudin
Bashkir State Medical University
Email: timk7@list.ru
ORCID iD: 0000-0001-6915-1673
SPIN-code: 5713-0671
assistant professor
Russian Federation, 3, Lenina str., Ufa, 450008Aleksandr V. Samorodov
Bashkir State Medical University
Email: avsamorodov@gmail.com
ORCID iD: 0000-0001-9302-499X
MD, Dr. Sci. (Med.)
Russian Federation, 3, Lenina str., Ufa, 450008References
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