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Post a Comment The influence of cholinergic drugs on electroencephalogram of the gonadectomized female rabbits
- Authors: Kuznetsova N.N.1
-
Affiliations:
- Institute of Experimental Medicine
- Issue: Vol 18, No 1 (2020)
- Pages: 23-28
- Section: Experimental Pharmacology
- URL: https://journal-vniispk.ru/RCF/article/view/34059
- DOI: https://doi.org/10.17816/RCF18123-28
- ID: 34059
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Abstract
The results of investigation has shown, that after the gonadectomy of the rabbits-females the general power of EEG spectrum (GPS of EEG) changed under influence of cholinergic drugs. The sterilizathion of the animals leads to disorders of interaction between M- and N-cholinergic mechanisms in the brain. In particular, blockade of M-cholinoreceptors by metamizyl in intact and ovariectomized rabbits increased the GPS of EEG. The simultaneous administration of metamizyl with galantamine to intact females led to even greater increase of GPS of EEG, whereas the sterilized rabbits demonstrated its reduction. On the contrary, the application of the N-cholinoreceptors inhibitor gangleron with inhibitor of acetylcholinesterase (AChE) galantamine reduced the GPS of EEG in intact animals and increased it in gonadectomized rabbits in comparison with gangleron alone. Thus, the effect of M,N-cholinoblockators in combination with AChE inhibitor in sterilized rabbits changed the EEG spectrum to opposite in comparison with intact females.
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##article.viewOnOriginalSite##About the authors
Natalia N. Kuznetsova
Institute of Experimental Medicine
Author for correspondence.
Email: Nat.kuz@mail.ru
PhD (Pharmacology), Senior Researcher, Department of Neuropharmacology
Russian Federation, Saint PetersburgReferences
- Байрамов А.А., Кузнецова Н.Н. Андроген-зависимое влияние М-холинолитика метамизила на биоэлектрическую активность головного мозга // Психофармакология и биологическая наркология. – 2006. – Т. 6. – № 1–2. – С. 1197–1203. [Bajramov AA, Kuznetsova NN. Androgen-dependent influence of m-cholinilitic metamyzyl on on bioelectric activity of the brain. Psychopharmacology and biological narcology. 2006;6(1-2):1197-1203. (In Russ.)]
- Денисенко П.П. Роль холинореактивных систем в регуляторных процессах. – М.: Медицина, 1980. – 295 с. [Denisenko PP. Rol’ kholinoreaktivnykh sistem v regulyatornykh protsessakh. Moscow: Meditsina; 1980. 295 p. (In Russ.)]
- Кузнецова Н.Н., Лосев Н.А. Влияние холинергических препаратов на изменение спектра мощности ЭЭГ у интактных и гонадо- и овариоэктомированных кроликов / Материалы IX Научно-практической конференции «Проблемы изучения резистентности организма к действию экстремальных факторов внешней среды»; Санкт-Петербург, 27 мая 2016 г. – СПб., 2016. – С. 74–79. [Kuznetsova NN, Losev NA. Kuznetsova NN, Losev NA. Vliyanie kholinergicheskikh preparatov na izmenenie spektra moshchnosti EEG u intaktnykh i gonado- i ovarioektomirovannykh krolikov In: Proceedings of the 9th Scientific and practical Сonference “Problemy izucheniya rezistentnosti organizma k deystviyu ekstremal’nykh faktorov vneshney sredy”. Saint Petersburg, 27 May 2016. Saint Petersburg; 2016. P. 74-79. (In Russ.)]
- Лосев Н.А. Реципрокность взаимодействия между М- и Н-холинергическими механизмами в единой системе. В кн.: Вопросы структурно-медиаторной организации и регенерации нервной системы. – Ленинград, 1985. – С. 72–80. [Losev NA. Retsiproknost’ vzaimodeystviya mezhdu M- i N-kholinergicheskimi mekhanizmami v edinoy sisteme. In: Voprosy strukturno-mediatornoy organizatsii i regeneratsii nervnoy sistemy. Leningrad; 1985. P. 72-80. (In Russ.)]
- Лосев Н.А., Сапронов Н.С., Хныченко Л.К., Шабанов П.Д. Фармакология новых холинергических средств (фармакология — клинике). – СПб, 2015. [Losev NA, Sapronov NS, Khnychenko LK, Shabanov PD. Farmakologiya novykh kholinergicheskikh sredstv (farmakologiya – klinike). Saint Petersburg; 2015. (In Russ.)]
- Gron G, Brandenburg I, Wunderlich AP, Riepe MW. Inhibition of hippocampal function in mild cognitive impairment: targeting the cholinergic hypothesis. Neurobiol Aging. 2006;27(1):78-87. https://doi.org/10.1016/j.neurobiolaging.2004.12.005.
- Martı́nez-Morales JR, López-Coviella I, Hernández-Jiménez JG, et al. Sex steroids modulate luteinizing hormone-releasing hormone secretion in a cholinergic cell line from the basal forebrain. Neuroscience. 2001;103(4):1025-1031. https://doi.org/10.1016/s0306-4522(01)00023-9.
- Simpkins JW, Green PS, Gridley KE, et al. Role of Estrogen Replacement Therapy in Memory Enhancement and the Prevention of Neuronal Loss Associated With Alzheimer’s Disease. Am J Med. 1997;103(3):19S-25S. https://doi.org/10.1016/s0002-9343(97)00260-x.
