Email this article 
Post a Comment Effect of the extract of dry Serratula centauroides on the behavior of white rats in tests with positive reinforcement
- Authors: Razuvaeva Y.G.1,2, Markova K.V.3, Toropova A.A.1,2, Olennikov D.N.1
-
Affiliations:
- Institute of General and Experimental Biology SB RAS
- Banzarov Buryat State University Republic of Buryatia
- Banzarov Buryat state University
- Issue: Vol 19, No 2 (2021)
- Pages: 237-242
- Section: Phytopharmacology
- URL: https://journal-vniispk.ru/RCF/article/view/57179
- DOI: https://doi.org/10.17816/RCF192237-242
- ID: 57179
Cite item
Open Access
Access granted
Subscription Access
Abstract
The effect was studied of dry leaf extract of Serratula centauroides L. on the behavior of white rats (Wistar) in tests with positive reinforcement. It was revealed that the extract of S. centauroides at doses of 50–200 mg/kg promotes in animals a decrease in the level of anxiety, adaptation to unfamiliar conditions, and as a consequence, to an increase in the volume of food intake. And also a more rapid formation of a conditioned reflex with positive reinforcement. In animals treated with S. centauroides extract, the volume of food taken in “hypophagia” test was 1.4–2.7 times higher than the control value. In the T-shaped maze, 50–80% of the animals in the experimental groups developed a conditioned reflex to positive reinforcement, while none of the animals in the control group reached the learning criterion. The S. centauroides extract showed the most pronounced effect on the behavior of animals in tests with positive reinforcement at a dose of 100 mg/kg.
Full Text
##article.viewOnOriginalSite##About the authors
Yanina G. Razuvaeva
Institute of General and Experimental Biology SB RAS; Banzarov Buryat State University Republic of Buryatia
Author for correspondence.
Email: tatur75@mail.ru
ORCID iD: 0000-0001-7829-1424
SPIN-code: 8338-9336
DSci. (Biology), Senior Research Scientist, laboratory for the safety of biologically active substances
Russian Federation, 8 str. Sakhyanovoy, Ulan-Ude 670047; 24а str. Smolina, Ulan-Ude 670000Kristina V. Markova
Banzarov Buryat state University
Email: kriskartland@gmail.com
ORCID iD: 0000-0002-2143-6925
SPIN-code: 5739-5350
Postgraduate student
Russian Federation, 24а str. Smolina, Ulan-Ude 670000Anyuta A. Toropova
Institute of General and Experimental Biology SB RAS; Banzarov Buryat State University Republic of Buryatia
Email: anyuta-tor@mail.ru
ORCID iD: 0000-0003-2618-7777
SPIN-code: 4457-1872
Ph.D. (Biology), Research Scientist, laboratory for the safety of biologically active substances
Russian Federation, 8 str. Sakhyanovoy, Ulan-Ude 670047; 24а str. Smolina, Ulan-Ude 670000Daniil N. Olennikov
Institute of General and Experimental Biology SB RAS
Email: olennikovdn@mail.ru
ORCID iD: 0000-0001-8194-1061
SPIN-code: 8901-3743
DSci. (Pharm.), Senior Research Scientist, laboratory of biomedical research
Russian Federation, 8 str. Sakhyanovoy, Ulan-Ude 670047References
- Olennikov DN, Kashchenko NI. Fitoehkdisteroidy nadzemnoi chasti Serratula centauroides, proizrastayushchei v Pribaikal’e. Khimija rastitel’nogo syr’ja. 2018;(2):37–44. (In Russ.)
- Sviridov IV, Razuvaeva YaG, Shantanova LN. Influence of dry extract Serratula centauroides L. On the functional status of central nervous system. Vestnik Buryatskogo gosudarstvennogo universiteta. 2015;(12):184–188. (In Russ.)
- Nikolaeva IG, Tsybiktarova LP, Garmaeva LL, et al. Determination of ecdysteroids in Fornicium unflorum (L.) and Serratula centauroides (L.) Raw materials by chromatography–uv spectrophotometry. Journal of Analytical Chemistry. 2017;72(8):733–741. (In Russ.) doi: 10.1134/S1061934817080093
- Shantanova LN, Dashiev DB, Radnaeva DB, et al. Adaptogeny v tibetskoi meditsine. Byulleten’ VSNTS SO RAN. 2008;(3):175. (In Russ.)
- Sviridov IV, Khobrakova VB, Shantanova LN. The immunocorrecting effect of the dry extract from Serratula centauroides. The Siberian medical journal. 2015;(5):120–122. (In Russ.)
- Sviridov IV. Adaptogennye svoistva ehkstrakta sukhogo Serratula centauroides [dissertation abstract]. Ulan-Ude, 2016. 23 p. (In Russ.)
- Garibova TL, Kraineva VA, Voronina TA. Animal models of depression. Pharmacokinetics and Pharmacodynamics. 2017;(3):14–19. (In Russ.)
- Mogilenko TG, Denisenko ON, Voronkov AV, et al. Izuchenie adaptogennoi i antigipoksicheskoi aktivnosti substantsii 20E, vydelennoi iz serpukhi pyatilistnoi (Serratula quinquefolia Bieb. ex Willd.), kul’tiviruemoi na Severnom Kavkaze. Modern Problems of Science and Education. Surgery. 2015;(2–3). Available at: http://science-education.ru/ru/article/view?id=23717. (In Russ.)
- Pchelenko LD, Metelkina LG, Volodina SO. Adaptogennyi ehffekt ehkdisteroidsoderzhashchei fraktsii Serratula coronata L. Khimija rastitel’nogo syr’ja. 2002;(1):69–80. (In Russ.)
- Bajguz A, Bąkała I, Talarek M. Chapter 5 – Ecdysteroids in Plants and their Pharmacological Effects in Vertebrates and Humans. Studies in Natural Products Chemistry. 2015;45:121–145. doi: 10.1016/B978-0-444-63473-3.00005-8
- Volodin VV, Sidorova YuS, Mazo VK. 20-hydroxyecdysone – plant adaptogen: an anabolic effect, possible use in sports nutrition. Problems of nutrition. 2013;82(6):24–30. (In Russ.)
- Cahlikova L, Macakova K, Chlebek J, et al. Ecdysterone and its Activity on some Degenerative Diseases. Natural Product Communications. 2011;6(5):707–718. doi: 10.1177/1934578X1100600527
- Mamadalieva NZ, Böhmdorfer S, Zengin G, et al. Phytochemical and biological activities of Silene viridiflora extractives. Development and validation of a HPTLC method for quantification of 20-hydroxyecdysone. Industrial Crops and Products. 2019;129:542–548. doi: 10.1016/j.indcrop.2018.12.041
- Lafont R, Dinan L. Current state of the problem of the practical use of ecdysteroids for mammals and humans. Vestnik Insituta biologii Komi NC UrO RAN. 2005;(3):2–18. (In Russ.)
- Galdino PM, Nascimento MМ, Florentino IF. The anxiolytic-like effect of an essential oil derived from Spiranthera odoratissima A. St. Hil. leaves and its major component, beta-caryophyllene, in male mice. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 2012;38(2):276–284. doi: 10.1016/j.pnpbp.2012.04.012.
