Role of short-chain fatty acids in the pathogenesis of Parkinson’s disease
- Authors: Krasakov I.V.1,2, Litvinenko I.V.1, Rodionov G.G.2, Davydova N.I.2, Aleksanin S.S.2
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Affiliations:
- Military Medical Academy
- Nikiforov All-Russian Center of Emergency and Radiation Medicine
- Issue: Vol 41, No 4 (2022)
- Pages: 439-444
- Section: Reviews
- URL: https://journal-vniispk.ru/RMMArep/article/view/111854
- DOI: https://doi.org/10.17816/rmmar111854
- ID: 111854
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Abstract
Parkinson’s disease is tightly related to enteric nervous system dysfunction and gut microbiota dysbiosis. Short-chain fatty acids are the main metabolites produced by the gut bacteria fermentation of dietary fiber and are suggested to play a key role in gut–brain cross-talk. The article presents a review of the literature on the contribution of short-chain fatty acids to the pathogenesis of Parkinson’s disease. Patients with Parkinson’s disease have higher plasma concentrations of acetate, propionate, and butyrate than controls. These changes correlate with the severity of the clinical picture of Parkinson’s disease, levels of pro-inflammatory gut bacteria and pro-inflammatory cytokines. The cause of these changes may be an over-population of the gut of Parkinson’s disease patients with bacteria such as clostridia and ruminococci, leading to regulatory immune reactions, intestinal inflammation, increased permeability of the intestinal barrier, excessive intake primarily of propionate in the central nervous system, and activation of neuroinflammation. The importance of further study of the relationship between changes in gut metabiotic, its metabolome, and the immune system T-cell in patients with Parkinson’s disease is demonstrated. Justified the study of blood plasma from patients with Parkinson’s disease using gas chromatography–mass spectrometry for the accurate, clinically relevant, assessment of the gut–brain crosstalk.
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##article.viewOnOriginalSite##About the authors
Igor V. Krasakov
Military Medical Academy; Nikiforov All-Russian Center of Emergency and Radiation Medicine
Email: ikrasakov@gmail.com
ORCID iD: 0000-0001-6092-0659
SPIN-code: 9891-8300
Scopus Author ID: 26642102200
ResearcherId: I-8865-2016
M.D., Ph.D. (Medicine)
Russian Federation, Saint Petersburg; Saint PetersburgIgor V. Litvinenko
Military Medical Academy
Author for correspondence.
Email: litvinenkoiv@rambler.ru
ORCID iD: 0000-0001-8988-3011
SPIN-code: 6112-2792
Scopus Author ID: 35734354000
ResearcherId: F-9120-2013
M.D., D.Sc. (Medicine), Professor
Russian Federation, Saint PetersburgGennadiy G. Rodionov
Nikiforov All-Russian Center of Emergency and Radiation Medicine
Email: rodgengeor@yandex.ru
SPIN-code: 6471-3933
M.D., D.Sc. (Medicine)
Russian Federation, Saint PetersburgNataliya I. Davydova
Nikiforov All-Russian Center of Emergency and Radiation Medicine
Email: davydova777@yandex.ru
ORCID iD: 0000-0001-8644-905X
SPIN-code: 7914-5866
M.D., Ph.D. (Medicine)
Russian Federation, Saint PetersburgSergey S. Aleksanin
Nikiforov All-Russian Center of Emergency and Radiation Medicine
Email: medicine@nrcerm.ru
ORCID iD: 0000-0001-6998-1669
SPIN-code: 1256-5967
M.D., D.Sc. (Medicine), Professor, corresponding member of RAS
Russian Federation, Saint PetersburgReferences
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