Email this article 
Post a Comment The dynamics of some health indicators in adult patients with cystic fibrosis, observed in the research institute of pulmonology in 2003-2018
- Authors: Krasovskiy S.A.1,2,3, Amelina E.L.1, Gorinova U.V.4, Chernyak A.V.1, Afanasjeva M.V.1, Krilova N.A.1, Shumkova G.L.1, Zonenko O.G.5, Tatarskiy A.R.1
-
Affiliations:
- Research Institute of Pulmonology of the Federal Medical-Biological Agency of Russia
- D.D. Pletnev City Clinical Hospital, Moscow Healthcare Department
- Research Centre of Medical Genetics
- National Medical Research Center for Children’s Health
- Russian National Research Medical University named after N.I. Pirogov
- Issue: Vol 9, No 4 (2018)
- Pages: 25-32
- Section: Original Study Articles
- URL: https://journal-vniispk.ru/clinpractice/article/view/10591
- DOI: https://doi.org/10.17816/clinpract9425-32
- ID: 10591
Cite item
Full Text
Abstract
Background: Evaluation of the main clinical and functional indicators and their relationship with the treatment and diagnostic care at different time periods can contribute to the development of further effective medical strategies and globally lead to improved care for cystic fibrosis patients.
Aim: An assessment of the dynamics of some clinical and functional indicators in adult CF patients, who have been observed ed Research Institute of Pulmonology during the last 15 years(2003–2018).
Methods: The comparative analysis was performed on the data of adult patients with cystic fibrosis, observed at 31.12.2003 and at the end of October of 2018. The group of patients in 2003 consists of 80 and in 2018 — of 667 patients. The comparative analysis between the groups was carried out according to the following indicators: age, survival, lung function, nutritional status, proportion of infection with pathogenic microflora, identification of mutations in the cystic fibrosis gene and diagnosis in adult patients.
Results: An increase in patient’s age, survival rate, the proportion of identified mutations in cystic fibrosis gene and infection of Burkholderia cepacia complex in the group of patients in 2018 was revealed. There were no differences in the state of lung function, nutritional status, the ratio of the living and dead patients and proportion of patients diagnosed in adulthood between groups.
Conclusion: The progress in the treatment through the introduction of modern methods and therapeutic programs leads to improved survival and an increase in the number of adult patients with cystic fibrosis.
Keywords
Full Text
##article.viewOnOriginalSite##About the authors
S. A. Krasovskiy
Research Institute of Pulmonology of the Federal Medical-Biological Agency of Russia; D.D. Pletnev City Clinical Hospital, Moscow Healthcare Department; Research Centre of Medical Genetics
Author for correspondence.
Email: sa_krasovsky@mail.ru
ORCID iD: 0000-0001-9642-0947
SPIN-code: 3385-6489
канд. мед. наук, старший научный сотрудник лаборатории муковисцидоза; врач-пульмонолог 2-го пульмонологического отделения; старший научный сотрудник научно-клинического отдела муковисцидоза
Russian Federation, 28, Orekchovy Boulevard, Moscow, 115682; MoscowE. L. Amelina
Research Institute of Pulmonology of the Federal Medical-Biological Agency of Russia
Email: eamelina@mail.ru
ORCID iD: 0000-0002-5356-9415
SPIN-code: 6341-4662
канд. мед. наук, заведующая лабораторией муковисцидоза
Russian Federation, 28, Orekchovy Boulevard, Moscow, 115682U. V. Gorinova
National Medical Research Center for Children’s Health
Email: ygorinova@yandex.ru
ORCID iD: 0000-0002-3881-3483
канд. мед. наук, врач-педиатр отделения муковисцидоза
Russian Federation, 2, b.1, Lomonosovsky prospekt, Moscow, 119991A. V. Chernyak
Research Institute of Pulmonology of the Federal Medical-Biological Agency of Russia
Email: achi2000@mail.ru
SPIN-code: 9328-6440
канд. мед. наук, заведующий лабораторией функциональных и ультразвуковых методов исследований
Russian Federation, 28, Orekchovy Boulevard, Moscow, 115682M. V. Afanasjeva
Research Institute of Pulmonology of the Federal Medical-Biological Agency of Russia
Email: usa-mariya@yandex.ru
SPIN-code: 7271-7408
научный сотрудник лаборатории муковисцидоза
Russian Federation, 28, Orekchovy Boulevard, Moscow, 115682N. A. Krilova
Research Institute of Pulmonology of the Federal Medical-Biological Agency of Russia
Email: nataliya_2007_78@mail.ru
ORCID iD: 0000-0002-3788-0887
научный сотрудник лаборатории муковисцидоза
Russian Federation, 28, Orekchovy Boulevard, Moscow, 115682G. L. Shumkova
Research Institute of Pulmonology of the Federal Medical-Biological Agency of Russia
Email: galina2212@yandex.ru
ORCID iD: 0000-0001-9076-2348
SPIN-code: 5053-3013
научный сотрудник лаборатории муковисцидоза
Russian Federation, 28, Orekchovy Boulevard, Moscow, 115682O. G. Zonenko
Russian National Research Medical University named after N.I. Pirogov
Email: o.zonenko@mail.ru
ORCID iD: 0000-0002-9142-2318
SPIN-code: 7726-6224
ассистент кафедры госпитальной педиатрии имени академика В.А. Таболина
Russian Federation, 1, Ostrovityanova street, Moscow, 117997A. R. Tatarskiy
Research Institute of Pulmonology of the Federal Medical-Biological Agency of Russia
Email: alexey.tatarsky@gmail.com
SPIN-code: 9734-2366
докт. мед. наук, профессор, руководитель образовательного центра
Russian Federation, 28, Orekchovy Boulevard, Moscow, 115682References
- Муковисцидоз. / Под ред. Н.И. Капранова, Н.Ю. Каширской. — M.: ИД «Медпрактика-М»; 2014. — 672 с. [Cystic fibrosis (Mucoviscidosis). Ed by NI Kapranov, NYu Kashirskaya. Moscow: Publishing House «Medpractika-M»; 2014. p. 672. (In Russ).]
- Национальный консенсус. Муковисцидоз: оп- ределение, диагностические критерии, терапия. / Под ред. Е.И. Кондратьевой, Н.Ю. Каширской, Н.И. Капранова. — М: ООО «Компания БОРГЕС»; 2016. — 205 с. [Natsional’nyj konsensus. Mukovistsidoz: opredelenie, diagnosticheskie kriterii, terapiya. Ed by EI Kondrat’evа, NYu Kashirskaya, NI Kapranov. Moscow: OOO «Kompaniya BORGES»; 2016. 205 р. (In Russ).]
- Красовский С.А., Амелина Е.Л., Черняк А.В., и др. Муковисцидоз взрослых: увеличение выживаемости больных в Москве и Московской области // Терапевтический архив. — 2012. — Т.84. — №3. — С. 54–58. [Krasovsky SA, Amelina EL, Chernyak AV, et al. Adult-onset mucoviscidosis: longer survival of patients in Moscow and Moscow region. Ter Arkh. 2012;84(3):54–58. (In Russ).]
- Каширская Н.Ю., Красовский С.А., Черняк А.В., и др. Динамика продолжительности жизни больных муковисцидозом, проживающих в Москве, и ее связь с получаемой терапией: ретроспективный анализ за 2003–2013 гг. // Вопросы современной педиатрии. — 2015. — Т.14. — №4. — С. 503–508. [Kashirskaya NYu, Krasovsky SA, Chernyak AV, et al. Trends in life expectancy of cystic fibrosis patients in Moscow and their connection with the treatment received: retrospective analysis for 1993–2013. Current Pediatrics. 2015;14(4):503–508. (In Russ).] doi: 10.15690/vsp.v14.i4.1390.
- Черняк А.В., Красовский С.А., Науменко Ж.К., и др. Динамика показателей функции внешнего дыхания у больных муковисцидозом после трансплантации легких // Пульмонология. — 2017. — Т.27. — №2. — С. 206–215. [Chernyak AV, Krasovskiy SA, Naumenko ZhK., et al. Change in lung function of patients with cystic fibrosis underwent lung transplantation. Pul`monologiya. (In Russ).] doi: 10.18093/0869-0189-2017-27-2-206-215.
- Крылова Н.А., Амелина Е.Л., Красовский С.А., и др. Энтеральное зондовое питание у взрослых больных муковисцидозом с дыхательной недостаточностью // Терапевтический архив. — 2017. — Т. 89. — №12. — С. 51–55. [Krylova NA, Amelina EL, Krasovsky SA, et al. Enteral tube feeding in adult patients with cystic fibrosis and respiratory failure. Ter Arkh.2017;89(12):51–55. (In Russ).] doi: 10.17116/terarkh2017891251-55.
- Амелина Е.Л., Красовский С.А., Усачёва М.В., Крылова Н.А. Патогенетическое лечение муковисцидоза: первый клинический случай в России // Пульмонология. — 2017. — Т.27. — №2. — С. 298–301. [Amelina EL, Krasovskiy SA, Usacheva MV, Krylova NA. Pathogenic treatment of cystic fibrosis: the first clinical case in Russia. Pul`monologiya. (In Russ).] doi: 10.18093/0869-0189-2017-27-2-298-301.
- Афанасьева М.В., Амелина Е.Л., Черняк А.В., и др. Выживаемость взрослых больных муковисцидозом с хронической инфекцией респираторного тракта, обусловленной микроорганизмами Burkholderia cepacia complex // Практическая пульмонология. — 2018. — №1. — С. 60–64. [Afanasieva MV, Amelina EL, Chernyak AV, et al. Survival of adult patients with cystic fibrosis and chronic respiratory infection caused by Burkholderia cepacia complex. Praktichtskaya pul`monologiya. 2018;(1):60–64. (In Russ).]
Supplementary files
