Email this article Expression of antimicrobial peptides in the epithelium of the cervix uteri after caesarian section and vaginal birth
- Authors: Lebedeva O.P.1, Ivashova O.N.1, Pakhomov S.P.1, Churnosov M.I.1, Samborskaya N.I.1, Fedorenko E.A.2
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Affiliations:
- Belgorod State National Research University
- Belgorod region clinical hospital of St. Ioasaf
- Issue: Vol 63, No 5 (2014)
- Pages: 58-63
- Section: Articles
- URL: https://journal-vniispk.ru/jowd/article/view/2697
- DOI: https://doi.org/10.17816/JOWD63558-63
- ID: 2697
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Abstract
The Background: Antimicrobial peptides are first line of defense for mucosa against viruses, bacteria, protozoa and fungi. Meanwhile, expression of antimicrobial peptides in postpartum period has not been studied. Objective: To estimate the expression of mRNA of antimicrobial peptides in epithelium of the cervix uteri after caesarean section and vaginal birth 3 or 4 days after delivery. Materials and methods: The data-sample consisted of 17 women after caesarean section and 46 women after vaginal delivery examined on days 3 or 4 of postpartum period. Quantitative reverse transcription PCR method was used to study mRNA expression of antimicrobial peptides. Statistical analysis was performed using Mann-Whitney criteria. Results: It was shown that higher level of expression of SLPI, HNP3, HD6 and HBD4 in the endocervix was present in women who delivered via caesarean section compared with those who had vaginal delivery. Conclusion: Women who underwent caesarean section exhibited increased expression of antimicrobial peptides compared to those who had vaginal birth. This increased expression can be attributed to multiple reasons such as differences in vaginal microflora restoration, different changes in hormone levels and also due to surgical trauma after operative delivery. The use of antimicrobial peptides can give new opportunities for prophylaxis and treatment of septic complications that occur in postpartum period.
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##article.viewOnOriginalSite##About the authors
Olga Petrovna Lebedeva
Belgorod State National Research University
Email: safonova2@yandex.ru
MD, PhD, associate professor of the department of obstetrics and gynaecology
Olesya Nikolaevna Ivashova
Belgorod State National Research University
Email: ivashovao2@yandex.ru
MD, postgraduate student of the department of obstetrics and gynaecology
Sergey Petrovich Pakhomov
Belgorod State National Research University
Email: pachomw@yandex.ru
MD, PhD, professor, head of the department of obstetrics and gynaecology
Mikhail Ivanovich Churnosov
Belgorod State National Research University
Email: churnosov@bsu.edu.ru
MD, PhD, professor, head of the department of medical biology
Nataliya Ivanovna Samborskaya
Belgorod State National Research University
Email: sambonatalya@yandex.ru
MD, specialist obstetrician-gynaecologist
Elena Anatolevna Fedorenko
Belgorod region clinical hospital of St. IoasafMD, specialist obstetrician-gynaecologist
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