Potential role of vitamin D in the prevention and treatment of type 1 diabetes mellitus
- Authors: Misharina E.V.1, Yarmolinskaya M.I.1,2, Abashova E.I.1
-
Affiliations:
- The Research Institute of Obstetrics, Gynecology, and Reproductology named after D.O. Ott
- North-Western State Medical University named after I.I. Mechnikov
- Issue: Vol 70, No 2 (2021)
- Pages: 91-105
- Section: Reviews
- URL: https://journal-vniispk.ru/jowd/article/view/70955
- DOI: https://doi.org/10.17816/JOWD70955
- ID: 70955
Cite item
Abstract
The incidence of type 1 diabetes mellitus is increasing worldwide, and the number of people with vitamin D deficiency in all age groups, including children and adolescents, is simultaneously growing in the world. Over the past decades, it has been found that vitamin D, in addition to participating in the regulation of calcium homeostasis and bone metabolism, has an anti-inflammatory and immunomodulatory effect. Epidemiological evidence suggests the involvement of vitamin D deficiency in the pathogenesis of type 1 diabetes mellitus. Polymorphisms in genes important for vitamin D metabolism also modulate the risk of type 1 diabetes mellitus. Several studies have evaluated the role of vitamin D as adjuvant immunomodulating therapy in patients with newly diagnosed type 1 diabetes mellitus. The purpose of this review is to present current data on the involvement of vitamin D in the pathogenesis of type 1 diabetes mellitus and to evaluate its role as a drug for the prevention of the disease and its use in treatment in addition to insulin therapy.
Keywords
Full Text
##article.viewOnOriginalSite##About the authors
Elena V. Misharina
The Research Institute of Obstetrics, Gynecology, and Reproductology named after D.O. Ott
Email: mishellena@gmail.com
ORCID iD: 0000-0002-0276-7112
SPIN-code: 7350-5674
Scopus Author ID: 386281
ResearcherId: К-2720-2018
MD, PhD
Russian Federation, 3 Mendeleevskaya line, Saint Petersburg, 199034Mariya I. Yarmolinskaya
The Research Institute of Obstetrics, Gynecology, and Reproductology named after D.O. Ott; North-Western State Medical University named after I.I. Mechnikov
Author for correspondence.
Email: m.yarmolinskaya@gmail.com
ORCID iD: 0000-0002-6551-4147
SPIN-code: 3686-3605
Scopus Author ID: 7801562649
ResearcherId: P-2183-2014
MD, PhD, DSci (Medicine), Professor, Professor of the Russian Academy of Sciences
Russian Federation, 3 Mendeleevskaya line, Saint Petersburg, 199034; Saint PetersburgElena I. Abashova
The Research Institute of Obstetrics, Gynecology, and Reproductology named after D.O. Ott
Email: abashova@yandex.ru
ORCID iD: 0000-0003-2399-3108
SPIN-code: 2133-0310
Scopus Author ID: 36503679200
ResearcherId: J-5436-2018
MD, PhD
Russian Federation, 3 Mendeleevskaya line, Saint Petersburg, 199034References
- Ajlamazjan JeK, Abashova EI, Arzhanova ON, et al. Saharnyj diabet i reproduktivnaja sistema zhenshhiny: rukovodstvo dlja vrachej. Moscow: GJeOTAR-Media; 2017. (In Russ.)
- Rewers M, Ludvigsson J. Environmental risk factors for type 1 diabetes. Lancet. 2016;387(10035):2340–2348. doi: 10.1016/S0140-6736(16)30507-4
- Patterson CC, Dahlquist GG, Gyürüs E, Green A, Soltész G; EURODIAB Study Group. Incidence trends for childhood type 1 diabetes in Europe during 1989-2003 and predicted new cases 2005-20: a multicentre prospective registration study. Lancet. 2009;373(9680):2027–2033. doi: 10.1016/S0140-6736(09)60568-7
- Vehik K, Dabelea D. The changing epidemiology of type 1 diabetes: why is it going through the roof? Diabetes Metab Res Rev. 2011;27(1):3–13. doi: 10.1002/dmrr.1141
- International Diabetes Federation [Internet]. IDF Diabetes Atlas. 8th edition. 2017. [cited 10 Sept 2018]. Available from: https://diabetesatlas.org/upload/resources/previous/files/8/IDF_DA_8e-EN-final.pdf
- Infante M, Ricordi C, Sanchez J, et al. Influence of vitamin D on islet autoimmunity and beta-cell function in type 1 diabetes. Nutrients. 2019;11(9):2185. doi: 10.3390/nu11092185
- Holick MF. The vitamin D deficiency pandemic: Approaches for diagnosis, treatment and prevention. Rev Endocr Metab Disord. 2017;18(2):153–165. doi: 10.1007/s11154-017-9424-1
- Huh SY, Gordon CM. Vitamin D deficiency in children and adolescents: epidemiology, impact and treatment. Rev Endocr Metab Disord. 2008;9(2):161–170. doi: 10.1007/s11154-007-9072-y
- Hilger J, Friedel A, Herr R, et al. A systematic review of vitamin D status in populations worldwide. Br J Nutr. 2014;111(1):23–45. doi: 10.1017/S0007114513001840
- Lopes VM, Lopes JR, Brasileiro JP, et al. Highly prevalence of vitamin D deficiency among Brazilian women of reproductive age. Arch Endocrinol Metab. 2017;61(1):21–27. doi: 10.1590/2359-3997000000216
- Karonova TL, Grinyova EN, NikitiM IL, et al The prevalence of vitamin D deficiency in the Northwestern region of the Russian Federation among the residents of St. Petersburg and Petrozavodsk. Osteoporosis and Bone Diseases. 2013;16(3):3–7. (In Russ.). doi: 10.14341/osteo201333-7
- Pigarova EA, Rozhinskaja LJa, Belaja ZhE, et al. Deficit vitamina D u vzroslyh: diagnostika, lechenie i profilaktika. Klinicheskie rekomendacii Ministerstva zdravoohranenija Rossijskoj Federacii. Ed by II Dedov, GA Mel’nichenko. Moscow; 2015. [cited 2021 Mar 17]. Available from: https://minzdrav.gov-murman.ru/documents/poryadki-okazaniya-meditsinskoy-pomoshchi/D %2019042014.pdf. (In Russ.)
- Kumar R, editors. Vitamin D: basic and clinical aspects. New York: Springer; 2012.
- Webb AR, Pilbeam C, Hanafin N, Holick MF. An evaluation of the relative contributions of exposure to sunlight and of diet to the circulating concentrations of 25-hydroxyvitamin D in an elderly nursing home population in Boston. Am J Clin Nutr. 1990;51(6):1075–1081. doi: 10.1093/ajcn/51.6.1075
- Christakos S, Dhawan P, Verstuyf A, Verlinden L, Carmeliet G. Vitamin D: Metabolism, molecular mechanism of action, and pleiotropic effects. Physiol Rev. 2016;96(1):365–408. doi: 10.1152/physrev.00014.2015
- Napiórkowska L, Franek E. Rola oznaczania witaminy D w praktyce klinicznej. Choroby Serca i Naczyń. 2009;6(4):203–210. [cited 2021 Mar 17]. Available from: https://journals.viamedica.pl/choroby_serca_i_naczyn/article/view/12035/9913
- Yu C, Xue H, Wang L, et al. Serum bioavailable and free 25-hydroxyvitamin D levels, but not its total level, are associated with the risk of mortality in patients with coronary Artery disease. Circ Res. 2018;123(8):996–1007. doi: 10.1161/CIRCRESAHA.118.313558
- Hossein-Nezhad A, Spira A, Holick MF. Influence of vitamin D status and vitamin D3 supplementation on genome wide expression of white blood cells: a randomized double-blind clinical trial. PLoS One. 2013;8(3):e58725. doi: 10.1371/journal.pone.0058725
- Wang Y, Zhu J, DeLuca HF. Where is the vitamin D receptor? Arch Biochem Biophys. 2012;523(1):123–133. doi: 10.1016/j.abb.2012.04.001
- Caprio M, Infante M, Calanchini M, et al. Vitamin D: not just the bone. Evidence for beneficial pleiotropic extraskeletal effects. Eat Weight Disord. 2017;22(1):27–41. doi: 10.1007/s40519-016-0312-6
- Gatti D, Idolazzi L, Fassio A. Vitamin D: not just bone, but also immunity. Minerva Med. 2016;107(6):452–460.
- White JH. Vitamin D metabolism and signaling in the immune system. Rev Endocr Metab Disord. 2012;13(1):21–29. doi: 10.1007/s11154-011-9195-z
- Prietl B, Treiber G, Pieber TR, Amrein K. Vitamin D and immune function. Nutrients. 2013;5:2502–2521. doi: 10.3390/nu5072502
- Overbergh L, Decallonne B, Valckx D, et al. Identification and immune regulation of 25-hydroxyvitamin D-1-alpha-hydroxylase in murine macrophages. Clin Exp Immunol. 2000;120(1):139–146. doi: 10.1046/j.1365-2249.2000.01204.x
- Stoffels K, Overbergh L, Giulietti A, et al. Immune regulation of 25-hydroxyvitamin-D3-1alpha-hydroxylase in human monocytes. J Bone Miner Res. 2006;21(1):37–47. doi: 10.1359/JBMR.050908
- Singh PK, van den Berg PR, Long MD, et al. Integration of VDR genome wide binding and GWAS genetic variation data reveals co-occurrence of VDR and NF-κB binding that is linked to immune phenotypes. BMC Genomics. 2017;18(1):132. doi: 10.1186/s12864-017-3481-4
- Jensen SS, Madsen MW, Lukas J, et al. Inhibitory effects of 1alpha,25-dihydroxyvitamin D(3) on the G(1)-S phase-controlling machinery. Mol Endocrinol. 2001;15(8):1370–1380. doi: 10.1210/mend.15.8.0673
- Piemonti L, Monti P, Sironi M, et al. Vitamin D3 affects differentiation, maturation, and function of human monocyte-derived dendritic cells. J Immunol. 2000;164(9):4443–4451. doi: 10.4049/jimmunol.164.9.4443
- Ferreira GB, Vanherwegen AS, Eelen G, et al. Vitamin D3 induces tolerance in human dendritic cells by activation of intracellular metabolic pathways. Cell Rep. 2015;10(5):711–725. doi: 10.1016/j.celrep.2015.01.013
- Amado Diago CA, García-Unzueta MT, Fariñas Mdel C, Amado JA. Calcitriol-modulated human antibiotics: New pathophysiological aspects of vitamin D. Endocrinol Nutr. 2016;63(2):87–94. doi: 10.1016/j.endonu.2015.09.005
- Korf H, Wenes M, Stijlemans B, et al. 1,25-Dihydroxyvitamin D3 curtails the inflammatory and T cell stimulatory capacity of macrophages through an IL-10-dependent mechanism. Immunobiology. 2012;217(12):1292–1300. doi: 10.1016/j.imbio.2012.07.018
- Zhang X, Zhou M, Guo Y, et al. 1,25-Dihydroxyvitamin D₃ Promotes High Glucose-Induced M1 Macrophage Switching to M2 via the VDR-PPARγ Signaling Pathway. Biomed Res Int. 2015;2015:157834. doi: 10.1155/2015/157834
- Zhang Y, Leung DY, Richers BN, et al. Vitamin D inhibits monocyte/macrophage proinflammatory cytokine production by targeting MAPK phosphatase-1. J Immunol. 2012;188(5):2127–2135. doi: 10.4049/jimmunol.1102412
- Müller K, Heilmann C, Poulsen LK, Barington T, Bendtzen K. The role of monocytes and T cells in 1,25-dihydroxyvitamin D3 mediated inhibition of B cell function in vitro. Immunopharmacology. 1991;21(2):121–128. doi: 10.1016/0162-3109(91)90015-q
- Heine G, Anton K, Henz BM, Worm M. 1alpha,25-dihydroxyvitamin D3 inhibits anti-CD40 plus IL-4-mediated IgE production in vitro. Eur J Immunol. 2002;32(12):3395–3404. doi: 10.1002/1521-4141(200212)32:12<3395::AID-IMMU3395>3.0.CO;2-#
- Chen S, Sims GP, Chen XX, et al. Modulatory effects of 1,25-dihydroxyvitamin D3 on human B cell differentiation. J Immunol. 2007;179(3):1634–1647. doi: 10.4049/jimmunol.179.3.1634
- Overbergh L, Decallonne B, Waer M, et al. 1alpha,25-dihydroxyvitamin D3 induces an autoantigen-specific T-helper 1/T-helper 2 immune shift in NOD mice immunized with GAD65 (p524-543). Diabetes. 2000;49(8):1301–1307. doi: 10.2337/diabetes.49.8.1301
- Boonstra A, Barrat FJ, Crain C, et al. 1alpha,25-Dihydroxyvitamin D3 has a direct effect on naive CD4(+) T cells to enhance the development of Th2 cells. J Immunol. 2001;167(9):4974–4980. doi: 10.4049/jimmunol.167.9.4974
- Dankers W, Colin EM, van Hamburg JP, Lubberts E. Vitamin D in autoimmunity: molecular mechanisms and therapeutic potential Front Immunol. 2017;7:697. doi: 10.3389/fimmu.2016.00697
- Cippitelli M, Santoni A. Vitamin D3: a transcriptional modulator of the interferon-gamma gene. Eur J Immunol. 1998;28(10):3017–3030. doi: 10.1002/(SICI)1521-4141(199810)28:10<3017::AID-IMMU3017>3.0.CO;2-6
- Chang SH, Chung Y, Dong C. Vitamin D suppresses Th17 cytokine production by inducing C/EBP homologous protein (CHOP) expression. J Biol Chem. 2010;285(50):38751–38755. doi: 10.1074/jbc.C110.185777
- Giulietti A, Gysemans C, Stoffels K, et al. Vitamin D deficiency in early life accelerates type 1 diabetes in non-obese diabetic mice. Diabetologia. 2004;47(3):451–462. doi: 10.1007/s00125-004-1329-3
- Mathieu C, Waer M, Casteels K, et al. Prevention of type I diabetes in NOD mice by nonhypercalcemic doses of a new structural analog of 1,25-dihydroxyvitamin D3, KH1060. Endocrinology. 1995;136(3):866–872. doi: 10.1210/endo.136.3.7867594
- Mathieu C, Laureys J, Sobis H, et al. 1,25-Dihydroxyvitamin D3 prevents insulitis in NOD mice. Diabetes. 1992;41(11):1491–1495. doi: 10.2337/diab.41.11.1491
- Gregori S, Giarratana N, Smiroldo S, et al. A 1alpha,25-dihydroxyvitamin D(3) analog enhances regulatory T-cells and arrests autoimmune diabetes in NOD mice. Diabetes. 2002;51(5):1367–1374. doi: 10.2337/diabetes.51.5.1367
- van Halteren AG, Tysma OM, van Etten E, et al. 1alpha,25-dihydroxyvitamin D3 or analogue treated dendritic cells modulate human autoreactive T cells via the selective induction of apoptosis. J Autoimmun. 2004;23(3):233–239. doi: 10.1016/j.jaut.2004.06.004
- Takiishi T, Ding L, Baeke F, et al. Dietary supplementation with high doses of regular vitamin D3 safely reduces diabetes incidence in NOD mice when given early and long term. Diabetes. 2014;63(6):2026–2036. doi: 10.2337/db13-1559
- Eizirik DL, Colli ML, Ortis F. The role of inflammation in insulitis and beta-cell loss in type 1 diabetes. Nat Rev Endocrinol. 2009;5(4):219–226. doi: 10.1038/nrendo.2009.21
- Wei Z, Yoshihara E, He N, et al. Vitamin D switches BAF complexes to protect β cells. Cell. 2018;173(5):1135–1149.e15. doi: 10.1016/j.cell.2018.04.013
- Norman AW, Frankel JB, Heldt AM, Grodsky GM. Vitamin D deficiency inhibits pancreatic secretion of insulin. Science. 1980;209(4458):823–825. doi: 10.1126/science.6250216
- Bland R, Markovic D, Hills CE, et al. Expression of 25-hydroxyvitamin D3-1alpha-hydroxylase in pancreatic islets. J Steroid Biochem Mol Biol. 2004;89–90(1–5):121–125. doi: 10.1016/j.jsbmb.2004.03.115
- Johnson JA, Grande JP, Roche PC, Kumar R. Immunohistochemical localization of the 1,25(OH)2D3 receptor and calbindin D28k in human and rat pancreas. Am J Physiol. 1994;267(3 Pt 1):E356–E360. doi: 10.1152/ajpendo.1994.267.3.E356
- Maestro B, Dávila N, Carranza MC, Calle C. Identification of a Vitamin D response element in the human insulin receptor gene promoter. J Steroid Biochem Mol Biol. 2003;84(2–3):223–230. doi: 10.1016/s0960-0760(03)00032-3
- Bourlon PM, Billaudel B, Faure-Dussert A. Influence of vitamin D3 deficiency and 1,25 dihydroxyvitamin D3 on de novo insulin biosynthesis in the islets of the rat endocrine pancreas. J Endocrinol. 1999;160(1):87–95. doi: 10.1677/joe.0.1600087
- Alvarez JA, Ashraf A. Role of vitamin D in insulin secretion and insulin sensitivity for glucose homeostasis. Int J Endocrinol. 2010;2010:351385. doi: 10.1155/2010/351385
- Cade C, Norman AW. Vitamin D3 improves impaired glucose tolerance and insulin secretion in the vitamin D-deficient rat in vivo. Endocrinology. 1986;119(1):84–90. doi: 10.1210/endo-119-1-84
- Ramos-Lopez E, Brück P, Jansen T, et al. CYP2R1 (vitamin D 25-hydroxylase) gene is associated with susceptibility to type 1 diabetes and vitamin D levels in Germans. Diabetes Metab Res Rev. 2007;23(8):631–636. doi: 10.1002/dmrr.719
- Cooper JD, Smyth DJ, Walker NM, et al. Inherited variation in vitamin D genes is associated with predisposition to autoimmune disease type 1 diabetes. Diabetes. 2011;60(5):1624–1631. doi: 10.2337/db10-1656
- Bailey R, Cooper JD, Zeitels L, et al. Association of the vitamin D metabolism gene CYP27B1 with type 1 diabetes. Diabetes. 2007;56(10):2616–2621. doi: 10.2337/db07-0652
- Hussein AG, Mohamed RH, Alghobashy AA. Synergism of CYP2R1 and CYP27B1 polymorphisms and susceptibility to type 1 diabetes in Egyptian children. Cell Immunol. 2012;279(1):42–45. doi: 10.1016/j.cellimm.2012.08.006
- Thorsen SU, Mortensen HB, Carstensen B, et al. No association between type 1 diabetes and genetic variation in vitamin D metabolism genes: a Danish study. Pediatr Diabetes. 2014;15(6):416–421. doi: 10.1111/pedi.12105
- Norris JM, Lee HS, Frederiksen B, et al. Plasma 25-Hydroxyvitamin D concentration and risk of islet autoimmunity. Diabetes. 2018;67(1):146–154. doi: 10.2337/db17-0802
- Tapia G, Mårild K, Dahl SR, et al. Maternal and newborn vitamin D-binding protein, vitamin D levels, vitamin D receptor genotype, and childhood type 1 diabetes. Diabetes Care. 2019;42(4):553–559. doi: 10.2337/dc18-2176
- Habibian N, Amoli MM, Abbasi F, et al. Role of vitamin D and vitamin D receptor gene polymorphisms on residual beta cell function in children with type 1 diabetes mellitus. Pharmacol Rep. 2019;71(2):282–288. doi: 10.1016/j.pharep.2018.12.012
- You WP, Henneberg M. Type 1 diabetes prevalence increasing globally and regionally: the role of natural selection and life expectancy at birth. BMJ Open Diabetes Res Care. 2016;4(1):e000161. doi: 10.1136/bmjdrc-2015-000161
- Pettitt DJ, Talton J, Dabelea D, et al. Prevalence of diabetes in U.S. youth in 2009: the SEARCH for diabetes in youth study. Diabetes Care. 2014;37(2):402–408. doi: 10.2337/dc13-1838
- Mayer-Davis EJ, Lawrence JM, Dabelea D, et al. Incidence trends of type 1 and type 2 diabetes among youths, 2002–2012. N Engl J Med. 2017;376(15):1419–1429. doi: 10.1056/NEJMoa1610187
- Karvonen M, Viik-Kajander M, Moltchanova E, et al. Incidence of childhood type 1 diabetes worldwide. Diabetes Mondiale (DiaMond) Project Group. Diabetes Care. 2000;23(10):1516–1526. doi: 10.2337/diacare.23.10.1516
- Karvonen M, Jäntti V, Muntoni S, et al. Comparison of the seasonal pattern in the clinical onset of IDDM in Finland and Sardinia. Diabetes Care. 1998;21(7):1101–1109. Corrected and republished from: Diabetes Care. 1998;21(10):1784. doi: 10.2337/diacare.21.7.1101
- Ostman J, Lönnberg G, Arnqvist HJ, et al. Gender differences and temporal variation in the incidence of type 1 diabetes: results of 8012 cases in the nationwide Diabetes Incidence Study in Sweden 1983–2002. J Intern Med. 2008;263(4):386–394. doi: 10.1111/j.1365-2796.2007.01896.x
- Mohr SB, Garland CF, Gorham ED, Garland FC. The association between ultraviolet B irradiance, vitamin D status and incidence rates of type 1 diabetes in 51 regions worldwide. Diabetologia. 2008;51(8):1391–1398. doi: 10.1007/s00125-008-1061-5
- Pozzilli P, Manfrini S, Crinò A, et al. Low levels of 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 in patients with newly diagnosed type 1 diabetes. Horm Metab Res. 2005;37(11):680–683. doi: 10.1055/s-2005-870578
- Greer RM, Portelli SL, Hung BS, et al. Serum vitamin D levels are lower in Australian children and adolescents with type 1 diabetes than in children without diabetes. Pediatr Diabetes. 2013;14(1):31–41. doi: 10.1111/j.1399-5448.2012.00890.x
- Federico G, Genoni A, Puggioni A, et al. Vitamin D status, enterovirus infection, and type 1 diabetes in Italian children/adolescents. Pediatr Diabetes. 2018;19(5):923–929. doi: 10.1111/pedi.12673
- Rasoul MA, Al-Mahdi M, Al-Kandari H, et al. Low serum vitamin-D status is associated with high prevalence and early onset of type-1 diabetes mellitus in Kuwaiti children. BMC Pediatr. 2016;16:95. doi: 10.1186/s12887-016-0629-3
- Littorin B, Blom P, Schölin A, et al. Lower levels of plasma 25-hydroxyvitamin D among young adults at diagnosis of autoimmune type 1 diabetes compared with control subjects: results from the nationwide Diabetes Incidence Study in Sweden (DISS). Diabetologia. 2006;49(12):2847–2852. doi: 10.1007/s00125-006-0426-x
- Bener A, Alsaied A, Al-Ali M, et al. High prevalence of vitamin D deficiency in type 1 diabetes mellitus and healthy children. Acta Diabetol. 2009;46(3):183–189. doi: 10.1007/s00592-008-0071-6
- Reinert-Hartwall L, Honkanen J, Härkönen T, et al. No association between vitamin D and β-cell autoimmunity in Finnish and Estonian children. Diabetes Metab Res Rev. 2014;30(8):749–760. doi: 10.1002/dmrr.2550
- Sørensen IM, Joner G, Jenum PA, et al. Maternal serum levels of 25-hydroxy-vitamin D during pregnancy and risk of type 1 diabetes in the offspring. Diabetes. 2012;61(1):175–178. doi: 10.2337/db11-0875
- Jacobsen R, Moldovan M, Vaag AA, et al. Vitamin D fortification and seasonality of birth in type 1 diabetic cases: D-tect study. J Dev Orig Health Dis. 2016;7(1):114–119. Corrected and republished from: J Dev Orig Health Dis. 2016;7(4):429. doi: 10.1017/S2040174415007849
- Miettinen ME, Reinert L, Kinnunen L, et al. Serum 25-hydroxyvitamin D level during early pregnancy and type 1 diabetes risk in the offspring. Diabetologia. 2012;55(5):1291–1294. doi: 10.1007/s00125-012-2458-8
- Dong JY, Zhang WG, Chen JJ, et al. Vitamin D intake and risk of type 1 diabetes: a meta-analysis of observational studies. Nutrients. 2013;5(9):3551–3562. doi: 10.3390/nu5093551
- Silvis K, Aronsson CA, Liu X, et al. Maternal dietary supplement use and development of islet autoimmunity in the offspring: TEDDY study. Pediatr Diabetes. 2019;20(1):86–92. doi: 10.1111/pedi.12794
- Hyppönen E, Läärä E, Reunanen A, et al. Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study. Lancet. 2001;358(9292):1500–1503. doi: 10.1016/S0140-6736(01)06580-1
- The EURODIAB Substudy 2 Study Group. Vitamin D supplement in early childhood and risk for Type I (insulin-dependent) diabetes mellitus. Diabetologia. 1999;42(1):51–54. doi: 10.1007/s001250051112
- Stene LC, Joner G; Norwegian Childhood Diabetes Study Group. Use of cod liver oil during the first year of life is associated with lower risk of childhood-onset type 1 diabetes: a large, population-based, case-control study. Am J Clin Nutr. 2003;78(6):1128–1134. doi: 10.1093/ajcn/78.6.1128
- Gorham ED, Garland CF, Burgi AA, et al. Lower prediagnostic serum 25-hydroxyvitamin D concentration is associated with higher risk of insulin-requiring diabetes: a nested case-control study. Diabetologia. 2012;55(12):3224–3227. doi: 10.1007/s00125-012-2709-8
- Munger KL, Levin LI, Massa J, et al. Preclinical serum 25-hydroxyvitamin D levels and risk of type 1 diabetes in a cohort of US military personnel. Am J Epidemiol. 2013;177(5):411–419. doi: 10.1093/aje/kws243
- Zhang J, Upala S, Sanguankeo A. Relationship between vitamin D deficiency and diabetic retinopathy: a meta-analysis. Can J Ophthalmol. 2017;52 Suppl 1:S39–S44. doi: 10.1016/j.jcjo.2017.09.026
- Engelen L, Schalkwijk CG, Eussen SJ, et al. Low 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3 levels are independently associated with macroalbuminuria, but not with retinopathy and macrovascular disease in type 1 diabetes: the EURODIAB prospective complications study. Cardiovasc Diabetol. 2015;14:67. doi: 10.1186/s12933-015-0231-2
- Shimo N, Yasuda T, Kaneto H, et al. Vitamin D deficiency is significantly associated with retinopathy in young Japanese type 1 diabetic patients. Diabetes Res Clin Pract. 2014;106(2):e41–e43. doi: 10.1016/j.diabres.2014.08.005
- Felício KM, de Souza ACCB, Neto JFA, et al. Glycemic variability and insulin needs in patients with type 1 diabetes mellitus supplemented with vitamin D: A pilot study using continuous glucose monitoring system. Curr Diabetes Rev. 2018;14(4):395–403. doi: 10.2174/1573399813666170616075013
- Bogdanou D, Penna-Martinez M, Filmann N, et al. T-lymphocyte and glycemic status after vitamin D treatment in type 1 diabetes: A randomized controlled trial with sequential crossover. Diabetes Metab Res Rev. 2017;33(3): e2865. doi: 10.1002/dmrr.2865
- Mishra A, Dayal D, Sachdeva N, Attri SV. Effect of 6-months’ vitamin D supplementation on residual beta cell function in children with type 1 diabetes: a case control interventional study. J Pediatr Endocrinol Metab. 2016;29(4):395–400. doi: 10.1515/jpem-2015-0088
- Giri D, Pintus D, Burnside G, et al. Treating vitamin D deficiency in children with type I diabetes could improve their glycaemic control. BMC Res Notes. 2017;10(1):465. doi: 10.1186/s13104-017-2794-3
- Gabbay MA, Sato MN, Finazzo C, et al. Effect of cholecalciferol as adjunctive therapy with insulin on protective immunologic profile and decline of residual β-cell function in new-onset type 1 diabetes mellitus. Arch Pediatr Adolesc Med. 2012;166(7):601–607. doi: 10.1001/archpediatrics.2012.164
- Panjiyar RP, Dayal D, Attri SV, et al. Sustained serum 25-hydroxyvitamin D concentrations for one year with cholecalciferol supplementation improves glycaemic control and slows the decline of residual β cell function in children with type 1 diabetes. Pediatr Endocrinol Diabetes Metab. 2018;2018(3):111–117. doi: 10.5114/pedm.2018.80992
- Shih EM, Mittelman S, Pitukcheewanont P, et al. Effects of vitamin D repletion on glycemic control and inflammatory cytokines in adolescents with type 1 diabetes. Pediatr. Diabetes. 2016. Vol. 17. No. 1. P. 36–43. doi: 10.1111/pedi.12238
- Perchard R, Magee L, Whatmore A, et al. A pilot interventional study to evaluate the impact of cholecalciferol treatment on HbA1c in type 1 diabetes (T1D). Endocr Connect. 2017;6(4):225–231. doi: 10.1530/EC-17-0045
- Niinistö S, Takkinen HM, Erlund I, et al. Fatty acid status in infancy is associated with the risk of type 1 diabetes-associated autoimmunity. Diabetologia. 2017;60(7):1223–1233. doi: 10.1007/s00125-017-4280-9
- Bi X, Li F, Liu S, et al. ω-3 Polyunsaturated fatty acids ameliorate type 1 diabetes and autoimmunity. J Clin Invest. 2017;127(5):1757–1771. doi: 10.1172/JCI87388
- Stene LC, Ulriksen J, Magnus P, Joner G. Use of cod liver oil during pregnancy associated with lower risk of Type I diabetes in the offspring. Diabetologia. 2000;43(9):1093–1098. doi: 10.1007/s001250051499
- Scientific Advisory Committee on Nutrition [Internet]. SACN Vitamin D and Health Report. London; 2016. [cited 3 September 2019]. Available from: https://www.gov.uk/government/publications/sacn-vitamin-d-and-health-report
- Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011;96(7):1911–1930. doi: 10.1210/jc.2011-0385
- Mazahery H, von Hurst PR. Factors affecting 25-hydroxyvitamin D concentration in response to vitamin D supplementation. Nutrients. 2015;7(7):5111–5142. doi: 10.3390/nu7075111
- Rak K, Bronkowska M. Immunomodulatory effect of vitamin D and its potential role in the prevention and treatment of type 1 diabetes mellitus-A narrative review. Molecules. 2018;24(1):53. doi: 10.3390/molecules24010053
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