Influence gene vdr3 genotypes and alleles on bone turnover in early postmenopausae

I. Е. Zazerskaya; Зазерская И. Е.; М. V. Aseev; Асеев М. В.; L. V. Kuznetsova; Кузнецова Л. В.; М. V. Moskalenko; Москаленко М. В.; Т. Е. Ivashenko; Иващенко Т. Э.; V. S. Baranov; Баранов В. С.

doi:10.17816/JOWD81636

Influence gene vdr3 genotypes and alleles on bone turnover in early postmenopausae

Authors: Zazerskaya I.Е.¹, Aseev М.V.¹, Kuznetsova L.V.¹, Moskalenko М.V.¹, Ivashenko Т.Е.¹, Baranov V.S.¹
Affiliations:
1. Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Issue: Vol 54, No 2 (2005)
Pages: 23-30
Section: Original study articles
URL: https://journal-vniispk.ru/jowd/article/view/81636
DOI: https://doi.org/10.17816/JOWD81636
ID: 81636

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Abstract

Studies on the genetics have focused on the regulation of bone mineral density (BMD) a major predictor of osteoporotic fracture risk. Evidence for a genetic contribution to BMD regulation comes primarily from twin studies — that’s hawed that between 50—70 % of variance in BMD is caused by genetic factors. A great deal of research has been done on gene candidate VDR.3 on 176 postmenopausal women (108 natural menopause and 69 surgical menopause). Polymorphisms of vitamin D receptor have been associated in our group with the speed of bone turnover, registries by DEXA with interval 12 months and DDR test. The every second patient with genotype tt has chance to accompany group with osteoporosis in postmenopausae. In group of women with highs speed of bone turnover frequency t allel in 3 time more than in group with slow bone turnover.

Keywords

gene VDR3, alleles, genotypes, natural, surgical postmenopausae, bone turnover