Email this article Borderline ovarian tumors: modern diagnostic criteria at the preoperative stage
- Authors: Tsypurdeyeva A.A.1, Protasova A.E.2, Solntseva I.A.2, Mikhelashvili L.I.2
-
Affiliations:
- The Research Institute of Obstetrics, Gynecology, and Reproductology named after D.O. Ott
- The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
- Issue: Vol 71, No 2 (2022)
- Pages: 61-68
- Section: Original study articles
- URL: https://journal-vniispk.ru/jowd/article/view/81798
- DOI: https://doi.org/10.17816/JOWD81798
- ID: 81798
Cite item
Open Access
Access granted
Subscription Access
Abstract
AIM: The aim of this study was to define and standardize the clinical and diagnostic criteria for borderline ovarian tumors at the preoperative stage.
MATERIALS AND METHODS: A retrospective analysis of 35 clinical case histories of patients with morphologically established borderline ovarian tumors has been conducted. Clinical and morphological data were analyzed: age, anamnesis, examination data, disease stage, histological study results. Laboratory parameters were assessed: CA-125 tumor marker level and ultrasound characteristics using criteria defined by IOTA, ADNEX and O-RADS groups.
RESULTS: A single cyst with a solid component was a typical ultrasound type of borderline ovarian tumors (45.71%). The application of the simple IOTA rules in regards to evaluating the formations proved possible in 100% of the cases and the formation was regarded as undefined in 62.86% of the cases. In 51.43% of the cases, the formation belonged to O-RADS 4 (10% to <50% risk of malignancy). The study of CA-125 tumor marker levels showed insufficient sensitivity, only 57.14% of patients having the parameter above the norm.
CONCLUSIONS: The application of the IOTA and O-RADS criteria allows for differentiating not only benign and malignant, but also borderline ovarian tumors, thus determining the choice of an organ-preserving treatment for patients of reproductive age.
Full Text
##article.viewOnOriginalSite##About the authors
Anna A. Tsypurdeyeva
The Research Institute of Obstetrics, Gynecology, and Reproductology named after D.O. Ott
Email: tsypurdeevan@mail.ru
ORCID iD: 0000-0001-7774-2094
SPIN-code: 5208-9707
MD, Cand. Sci. (Med.)
Russian Federation, Saint PetersburgAnna E. Protasova
The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: protasova1966@yandex.ru
ORCID iD: 0000-0001-7930-8048
MD, Dr. Sci. (Med.), Assistant Professor
Russian Federation, Saint PetersburgIrina A. Solntseva
The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Email: protasova1966@yandex.ru
ORCID iD: 0000-0002-2692-2156
MD, Cand. Sci. (Med.)
Russian Federation, Saint PetersburgLina I. Mikhelashvili
The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O. Ott
Author for correspondence.
Email: lina.michelashvili@gmail.com
Russian Federation, Saint Petersburg
References
- Gozman ES, Makarova NA. Histological, genetic, immunohistochemical markers of borderline ovarian tumors. Vestnik Volgogradskogo gosudarstvennogo medicinskogo universiteta. 2021;(3):8–14. (In Russ.). doi: 10.19163/1994-9480-2021-3(79)-8-14
- Novikova EG, Shevchuk AS. Sovremennye podkhody k lecheniyu bol’nykh s pogranichnymi opukholyami yaichnikov. Oncogynecology. 2014;(4):45–58. (In Russ.)
- Davydova IYu, Kuznetsov VV, Karseladze AI, Meshcheryakova LA. Borderline ovarian tumors. Akusherstvo i ginekologiya. Novosti. Mneniya. Obucheniya. 2019;(7):92–104. (In Russ.). doi: 10.24411/2303-9698-2019-11013
- Davydova IYu, Kuznetsov VV, Karseladze AI, Meshcheryakova LA. Borderline ovarian tumors: а modern view of the problem. Opukholi zhenskoy reproduktivnoy sistemy. 2014;(2):53–55. (In Russ.)
- Davydova IYu, Ashrafyan LA, Karseladze AI, et al. Prakticheskie rekomendatsii po lecheniyu pogranichnykh opukholey yaichnikov. Zlokachestvennye opukholi. 2021;10(3s2–1):210–220. (In Russ.). doi: 10.18027/2224-5057-2019-9-3s2-192-202
- Bourdel N, Huchon C, Abdel Wahab C, et al. Borderline ovarian tumors: Guidelines from the French national college of obstetricians and gynecologists (CNGOF). Eur J Obstet Gynecol Reprod Biol. 2021;(256):492–501. doi: 10.1016/j.ejogrb.2020.11.045
- Flicek KT, van Buren W, Dudiak K, et al. Borderline epithelial ovarian tumors: what the radiologist should know. Abdom Radiol (NY). 2021;(46):2350–2366. (In Russ.). doi: 10.1007/s00261-020-02688-z
- Tamakoshi K, Kikkawa F, Shibata K, et al. Clinical value of CA125, CA19-9, CEA, CA72-4, and TPA in borderline ovarian tumor. Gynecol Oncol. 1996;62(1):67–72. (In Russ.). doi: 10.1006/gyno.1996.0191
- Vasil’ev AN, Krasil’nikov SE, Voytsitskiy VE, et al. Onkomarkery SA 125, NE 4 kak prediktornye faktory prognoza u bol’nykh s pogranichnymi opukholyami yaichnikov. Sibirskiy onkologicheskiy zhurnal. 2015;(4):39–44. (In Russ.)
- Timmerman D, van Calster B, Testa AC, et al. Ovarian cancer prediction in adnexal masses using ultrasound-based logistic regression models: a temporal and external validation study by the IOTA group. Ultrasound Obstet Gynecol. 2010;(36):226–234.
- Garg S, Kaur A, Mohi JK, et al. Evaluation of IOTA simple ultrasound rules to distinguish benign and malignant ovarian tumours. J Clin Diagn Res. 2017;11(8):TC06–TC09. doi: 10.7860/JCDR/2017/26790.10353
- Kaijser J, Sayasneh A, van Hoorde K, et al. Presurgical diagnosis of adnexal tumours using mathematical models and scoring systems: a systematic review and meta-analysis. Hum Reprod Update. 2014;20(3):449–462. doi: 10.1093/humupd/dmt059
- Adamyan LV, Andreeva EN, Artymuk NV, et al. Diagnostika i lechenie dobrokachestvennykh novoobrazovaniy yaichnikov s pozitsii profilaktiki raka. Klinicheskie rekomendatsii. Problemy reproduktsii. 2018;24(S6) 827–855. (In Russ.)
- Van Calster B, Van Hoorde K, Valentin L, et al. Evaluating the risk of ovarian cancer before surgery using the ADNEX model to differentiate between benign, borderline, early and advanced stage invasive, and secondary metastatic tumours: prospective multicentre diagnostic study. BMJ. 2014;349:g5920. doi: 10.1136/bmj.g5920
- Andreotti RF, Timmerman D, Strachowski LM, et al. O-RADS US risk stratification and management system: A consensus guideline from the ACR ovarian-adnexal reporting and data system committee. Radiology. 2020;294(1):168–185. (In Russ.). doi: 10.1148/radiol.2019191150
Supplementary files
