To the question of pathogenesis of perinatal pathology in pregnant women with genital chlamydiosis

The aim of the investigation was the assessment of humoral immunity in neonates and their mothers, who had genital chlamydiosis during pregnancy in correlation with results of immunomorphological and histological investigation of placenta with the significance of these disturbances for the development of perinatal pathology. 48 tern neonates and their mothers, who had genital chlamydiosis during pregnancy composed the main group, 16 healthy neonates and their mothers composed a control group. Decreasing in adaptation and. immunoresistive processes were found in 60,4% neonates from mothers with chlamydiosis. It was shown that the condition of neonates correlates with placental changes. In placentas of sick neonates, the highest level of fixed immune complex with excessive contents of C3b fraction of complement and IgM were seen. Our investigation showed that perinatal pathology in neonates from mothers with chlamydiosis could be a result of intrauterine C. trachomatis infection, and a consequence, of immunity disturbances in the system “mother-placenta-fetus”.