Molecular neuroimmunoendocrinology: role and significance in the regulation of reproductive function

The review paper is devoted to analysis of current molecular biological investigations, which testify on the molecular chemical unity of the signaling mechanisms into three classical regulatory systems-nervous, endocrine and immune ones. This biological general phenomenon allows to create a new special field of biomedicine-neuroimmunoendocrinology, which studies the structural-functional basis and molecular unity of neuroimmunoendocrine regulation of homeostasis in norm and pathology. The special attention pays on the presence of nervous, endocrine and immune cells in the reproductive system, which produce hormonal substances (regulatory peptides, biogenic amines, and related molecules) in situ inside endometrium, placenta, mammary glands. The role of these molecules in the mechanisms of reproduction is discussed.