The peculiarities of osteal system maturation in patients w ith primary estrogenic deficit

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Abstract

In patients with congenital ovarian insufficiency, particularly with gonadal dysgenesis, the retarded bone remodelingprevents the bone tissue from achieving its final, peak density and leads to the lagging of skeletal system maturation. This may result in high risk of limb and backbone fractures.
The article analyzes the results of the examination of 142 patients with different forms of gonadal dysgenesis. The treatment included the preparations containing estrogens, which were identical with natural ones (Divina, Divitren, Divigel). The data received substantiate the necessity of eliminating the estrogenic deficit in patients with gonadal dysgenesis earlier than it is usually done.

About the authors

E. V. Uvarova

Scientific Center for Obstetrics, Gynecology and Perinatology, Russian Academy of Medical Sciences

Email: info@eco-vector.com
Russian Federation, Moscow

A. I. Volobuev

Scientific Center for Obstetrics, Gynecology and Perinatology, Russian Academy of Medical Sciences

Email: info@eco-vector.com
Russian Federation, Moscow

T. V. Rudneva

Scientific Center for Obstetrics, Gynecology and Perinatology, Russian Academy of Medical Sciences

Email: info@eco-vector.com
Russian Federation, Moscow

S. V. Rudnev

Scientific Center for Obstetrics, Gynecology and Perinatology, Russian Academy of Medical Sciences

Author for correspondence.
Email: info@eco-vector.com
Russian Federation, Moscow

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