The role of heat shock protein 90 in malignant neoplasms of the female reproductive system: diagnostic and therapeutic potential. A literature review

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Abstract

The study of malignant neoplasms of the female reproductive system remains a crucial issue in modern oncology, requiring new approaches to diagnosis and treatment. One of the promising molecular targets for therapy is heat shock protein 90, which plays a key role in stabilizing oncoproteins, regulating cellular stress, and modulating signaling pathways. Its overexpression is associated with aggressive tumor growth, metastasis, reduced sensitivity to therapy, and poor prognosis.

This review analyzes publications that address the role of heat shock protein 90 in cervical, ovarian, and uterine cancer. An analysis of 3955 papers from PubMed/MEDLINE, 115 studies from eLibrary, and 2725 publications from Google Scholar was conducted, covering the period from the inception of these databases to August 2024. The findings indicate a significant impact of heat shock protein 90 on tumor progression, its ability to prevent apoptosis, and contribution to drug resistance.

Heat shock protein 90 inhibitors are being actively investigated as potential therapeutic agents to suppress the activity of this protein and induce tumor regression. Preclinical and clinical trials have demonstrated their efficacy in reducing tumor size and decreasing the risk of recurrence. However, the toxicity and selectivity of the inhibitors remain unresolved.

The development of monoclonal antibody-based medications targeting heat shock protein 90 is promising and may provide higher specificity and reduce adverse effects. Further studies are needed to optimize therapeutic efficacy, improve the selectivity and bioavailability of the inhibitors, and identify potential biomarkers of response to therapy.

About the authors

Irina S. Rvacheva

Rostov State Medical University

Email: lolemost@ro.ru
ORCID iD: 0009-0004-0909-3001
Russian Federation, Rostov-on-Don

Dzhaminat A. Apatova

Rostov State Medical University

Email: apatova.jaminat@ya.ru
ORCID iD: 0009-0007-2077-247X
Russian Federation, Rostov-on-Don

Laurita Zh. Movsesyan

Rostov State Medical University

Email: movsesyan.ll@mail.ru
ORCID iD: 0009-0001-6291-0806
Russian Federation, Rostov-on-Don

Dmitry I. Yudin

Rostov State Medical University

Email: dmitryiyudinn@gmail.com
ORCID iD: 0009-0002-8293-9080
Russian Federation, Rostov-on-Don

Diana S. Logvinova

Rostov State Medical University

Email: diana.logvinova2001@mail.ru
ORCID iD: 0009-0009-4458-7548
Russian Federation, Rostov-on-Don

Milana O. Bichegkueva

Rostov State Medical University

Email: milanabichegkueva@gmail.com
ORCID iD: 0009-0001-9603-8454
Russian Federation, Rostov-on-Don

Darya E. Deryabina

St. Petersburg State University

Email: dr.deryabina@mail.ru
ORCID iD: 0009-0007-0472-5198
Russian Federation, Saint Petersburg

Alexandra A. Timakova

Pirogov Russian National Research Medical University

Email: alexandra.timackova@yandex.ru
ORCID iD: 0009-0008-5782-0364
Russian Federation, Moscow

Darya D. Prikhodko

Pirogov Russian National Research Medical University

Email: sivaeva06111992@gmail.com
ORCID iD: 0009-0007-4100-236X
Russian Federation, Moscow

Elizaveta I. Budalova

Children’s Polyclinic No. 58

Email: lizokaz@yandex.ru
ORCID iD: 0009-0004-5514-2820
Russian Federation, Moscow

Aygun M. Alieva

Samara State Medical University

Email: aygun.alieva.0101@mail.ru
ORCID iD: 0009-0005-5110-2079
Russian Federation, Samara

Alexandra A. Musina

Samara State Medical University

Email: alten_m@mail.ru
ORCID iD: 0009-0004-5040-7287
Russian Federation, Samara

Georgy G. Davydov

Tula State University

Author for correspondence.
Email: sapdvach1984@gmail.com
ORCID iD: 0009-0002-7157-0353
Russian Federation, Tula

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