俄罗斯B组链球菌毒力岛PAI-A和PAI-A1的流行率

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组链球菌B或Streptococcus agalactiae是新生儿和成人严重疾病的病原体。组链球菌B的移动遗传元件中发现了分别含有sspB1和sspB1a基因的致病岛PAI-A和PAI-A1。SspB基因的存在与泌尿生殖道感染相关。本研究的目的是确定与来自圣彼得堡的菌株相比，在莫斯科流通的具有致病性岛PAI-A和PAI-A1的组链球菌菌株B的出现频率。莫斯科菌株的基因组中未检测到sspB1基因以及PAI-A致病岛。临床菌株基因组中sspB1a基因和PAI-A1致病岛的出现频率是定植菌株基因组的3倍。因此，可以假设sspB家族的基因更具有定植孕妇和新生儿的B组链球菌的特征。

作者简介

Evgenia Kuleshevich

Institute of Experimental Medicine

Email: k-zh-v@mail.ru
ORCID iD: 0000-0002-3180-6491

Cand. Sci. (Biol.)

俄罗斯联邦, Saint Petersburg

Yury Ilyasov

Institute of Experimental Medicine

Email: kolpino@hotmail.com
SPIN 代码: 2204-1677
俄罗斯联邦, Saint Petersburg

Dmitry Linnik

Institute of Experimental Medicine

Email: linnikdm@yandex.ru
ORCID iD: 0000-0002-8046-9743
俄罗斯联邦, Saint Petersburg

Anastasia Malchenkova

Institute of Experimental Medicine

Email: nastya.malchenkova@yandex.ru
ORCID iD: 0000-0003-2201-0472
SPIN 代码: 8957-5056
俄罗斯联邦, Saint Petersburg

Olga Arzhanova

Research Institute of Obstetrics, Gynecology, and Reproductology named after D.O. Ott,
Saint Petersburg State University

Email: arjanova_olga@mail.ru
ORCID iD: 0000-0003-3059-9811

MD, Dr. Sci. (Med.), Professor, Honored Doctor of the Russian Federation, Leading Researcher. The Department of Obstetrics and Perinatology; Professor. The Department of Obstetrics, Gynecology, and Reproductive Sciences, Medical Faculty

俄罗斯联邦, 3 Mendeleevskaya Line, Saint Petersburg, 199034; 7-9 Universitetskaya emb., St. Petersburg, 199034

Nikolay Briko

I.M. Sechenov First Moscow State Medical University

Email: nbrico@mail.ru
ORCID iD: 0000-0002-6446-2744
SPIN 代码: 2992-6915

MD, Dr. Sci. (Med.), Professor, Honored Scientist of the Russian Federation, Academician of the Russian Academy of Sciences

俄罗斯联邦, 8-2 Trubetskaya str., Moscow, 119991

Ekaterina Glushkova

I.M. Sechenov First Moscow State Medical University

Email: ekaterina-1801@mail.ru
ORCID iD: 0000-0001-6997-7598
SPIN 代码: 2336-3176

MD, Cand. Sci. (Med.)

俄罗斯联邦, 8-2 Trubetskaya str., Moscow, 119991

Tatyana Priputnevich

National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov

Email: priput1@gmail.com
ORCID iD: 0000-0002-4126-9730
SPIN 代码: 8383-7023

MD, Dr. Sci. (Med.)

俄罗斯联邦, 4 Street Akademika Oparina, Moscow, 117997

Alexander Suvorov

Institute of Experimental Medicine; Saint Petersburg State University

编辑信件的主要联系方式.
Email: alexander_suvorov1@hotmail.com
ORCID iD: 0000-0003-2312-5589
SPIN 代码: 8062-5281

MD, Dr. Sci. (Med.), Professor, Corresponding Member of the Russian Academy of Sciences

俄罗斯联邦, Saint Petersburg; Saint Petersburg

参考

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2. 图1 B组链球菌致病岛PAI-A和PAI-A1的结构。垂直线表示同源区域

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3. 图2 SspB1a：基因临床菌株聚合酶链反应产物的电泳图谱：1 - 菌株2978、2 - 菌株3093、3 - 菌株2828、 4 - 菌株3481、5 - 菌株3482、6 - 菌株2698、7 - 菌株3085、 8 - 菌株3030、9 - 阳性对照

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版权所有 © Kuleshevich E., Ilyasov Y., Linnik D., Malchenkova A., Arzhanova O., Briko N., Glushkova E., Priputnevich T., Suvorov A., 2021



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