Prospects for clinical use of agents acting on ATP receptors - P2-purinoreceptors

In addition to the well-known role of purine compounds in cell metabolism, growth, and reproduction, extensive factual material has been accumulated over the past two decades, demonstrating the important role of purines in intercellular interactions. It has been established that a number of physiological and pathophysiological reactions lead to the release of purine compounds (mainly adenosine and adenosine-5'-triphosphoric acid-ATP) by cells, which can interact with special receptors for them, purine receptors. The latter are subdivided into two main classes: PPpurinoreceptors and P2-purinoreceptors, whose main endogenous ligands are adenosine and ATP, respectively.