Hemostatic system parameters and level of magnesium in patients with beta-thalassemiа
- Authors: Aliyeva NR1
-
Affiliations:
- Scientific research institute of hematology and blood transfusion named after B. Eyvazov
- Issue: Vol 101, No 2 (2020)
- Pages: 188-192
- Section: Theoretical and clinical medicine
- URL: https://journal-vniispk.ru/kazanmedj/article/view/26273
- DOI: https://doi.org/10.17816/KMJ2020-188
- ID: 26273
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Abstract
Aim. To study the hemostatic system parameters and magnesium levels in patients with beta-thalassemia.
Methods. The object of the study was the blood serum of 96 women with beta-thalassemia: 46 patients with intermediate beta-thalassemia and 50 patients with beta-thalassemia minor, without clinical manifestations of hypercoagulation. The blood serum of 30 healthy donors was used as the control group. It was studied hemostasis system parameters: platelet count activated partial thromboplastin time (aPTT), prothrombin time, plasma fibrinogen level, D-dimer level, euglobulin clot lysis time, antithrombin III activity. The serum magnesium level and risk of deficiency were determined using the MDQ questionnaire.
Results. In patients with intermediate beta-thalassemia, an increase in the level of thrombinemia marker D-dimer (>500 ng/ml) was revealed. Patients with intermediate beta-thalassemia were divided into two groups according to the revealed level of D-dimer: 14 (30.4±6.8%) patients with latent hypercoagulation in group 1 and 32 (69.6±6.8%) patients without latent hypercoagulation in group 2. It was found that in the group with a high levels D-dimer, fibrinogen level was increased (p <0.05), fibrinolysis time was prolonged (p <0.05), activated partial thromboplastin time was shortened (p <0.05), and antithrombin III activity was slightly reduced (p >0.05). The serum magnesium level in patients of the first group was lower (t=7.3; p <0.001), and the risk of deficiency in the questionnaire was higher than in patients of the second group (r=–0.785, p <0.05). Hemostasis and magnesium levels in patients with beta-thalassemia minor did not differ from the control group (p >0.05).
Conclusion. One-third of patients with intermediate beta-thalassemia have a pre-thrombotic state for hemostasis — latent hypercoagulation and magnesium deficiency which can be predictors of clinical signs of thrombosis.
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##article.viewOnOriginalSite##About the authors
N R Aliyeva
Scientific research institute of hematology and blood transfusion named after B. Eyvazov
Author for correspondence.
Email: doktor.narqiz@mail.ru
Azerbaijan, Baku, Azerbaijan
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