Issues of prevention of chronic hepatitis and liver cirrosis in the light of the data of the lateral pathology

Development of preventive measures is impossible without knowledge of the etiological factors and pathogenesis of chronic liver damage. There is still no clarity regarding the etiology of liver cirrhosis, which is the outcome of unfavorable chronic hepatitis. It can be considered undoubtedly proven that Botkin's disease prevails among these reasons. After the huge pandemic of the last world war and the subsequent ones, the percentage of liver cirrhosis associated with Botkin's disease is constantly growing. Based on our material (Tajikistan), a study of the anamnesis of patients with liver cirrhosis showed that over 5 years the percentage of patients with cirrhosis who had suffered Botkin's disease in the past increased from 18 to 33, with a significantly lower percentage in the control groups (0-6%, respectively). In some statistics, this percentage is even higher. However, in the data of the authors of the beginning of the century, as well as the 30s. on a considerable number of patients with cirrhosis, Botkin's disease does not even find a place for itself in the list of diseases suffered in the past by patients (S. V. Chapman, A. M. Snell a. G. Rowntreçh, 1931 - 112 patients; N. Evans A. R. A. Gray, 1938 - 217 patients, etc.). In the 40s, during and after the war, Botkin's disease in the history of patients with cirrhosis of the liver already reaches 1.5-13% (JD Fagin A. R. Thompson - 1944; B. Rosenacka.oth., 1949, etc.) ... K. Howard a. S. J. Watson (1947) has already found among patients with cirrhosis of the liver 17% of those who have had infectious hepatitis in the past, compared with 3% who have had this disease among people with other diseases.