Capabilities of gravitational surgery for improvement of treatment results in patients with diabetic foot syndrome
- Authors: Akhmedov MB1, Abushov NS1, Zakirdzaev ED.1, Kosaev D.V1, Babaev NI1, Kuliev RA1, Tagizade GT1
-
Affiliations:
- Scientific Centre of Surgery named after M.A. Topchubashov
- Issue: Vol 99, No 3 (2018)
- Pages: 385-391
- Section: Theoretical and clinical medicine
- URL: https://journal-vniispk.ru/kazanmedj/article/view/8887
- DOI: https://doi.org/10.17816/KMJ2018-385
- ID: 8887
Cite item
Full Text
Abstract
Aim. Improvement of complex treatment results in patients with diabetic foot syndrome by introducing methods of gravitational surgery and α-lipoic acid.
Methods. The results of treatment were analyzed for 558 patients with diabetic foot syndrome treated in Scientific Centre of Surgery named after M.A. Topchubashov (Baku, Azerbaijan) from 1988 to 2015. The age varied from 28 to 83 years. The patients included 416 men and 142 women. The control group included 90 patients who at the perioperative period underwent basic therapy including antibiotics, anticoagulants, antiaggregants, dextrans, angioprotectors, spasmolytics, corticosteroids, narcotic and non-narcotic analgesics. The study group included 468 patients, along with traditional therapy receiving efferent methods (plasmapheresis, ultraviolet blood irradiation, ozone therapy) and α-lipoic acid. 282 patients of the study group received outpatient treatment and 186 - complex inpatient surgical treatment. A comparative evaluation of the results was performed separately in three groups: angiopathy, neuropathy, angioneuropathy. The results were evaluated by clinical and instrumental examinations before and after treatment (6, 12, 60 months and more).
Results. In the study group a satisfactory result of treatment was registered in 85.5% of patients, in the control group - in 62.2%, unsatisfactory in 14.5 and 37.8% of patients, respectively (p=0.046).
Conclusion. The use of efferent methods and α-lipoic acid provided prompt elimination of numerous pathogenetic disorders observed in diabetes mellitus, decrease of amputation frequency and improvement of complex surgical treatment results in patients with diabetic foot syndrome.
Full Text
##article.viewOnOriginalSite##About the authors
M B Akhmedov
Scientific Centre of Surgery named after M.A. Topchubashov
Author for correspondence.
Email: m.b.alisoy@gmail.com
Baku, Azerbaijan
N S Abushov
Scientific Centre of Surgery named after M.A. Topchubashov
Email: m.b.alisoy@gmail.com
Baku, Azerbaijan
E Dz Zakirdzaev
Scientific Centre of Surgery named after M.A. Topchubashov
Email: m.b.alisoy@gmail.com
Baku, Azerbaijan
Dz V Kosaev
Scientific Centre of Surgery named after M.A. Topchubashov
Email: m.b.alisoy@gmail.com
Baku, Azerbaijan
N I Babaev
Scientific Centre of Surgery named after M.A. Topchubashov
Email: m.b.alisoy@gmail.com
Baku, Azerbaijan
R A Kuliev
Scientific Centre of Surgery named after M.A. Topchubashov
Email: m.b.alisoy@gmail.com
Baku, Azerbaijan
G T Tagizade
Scientific Centre of Surgery named after M.A. Topchubashov
Email: m.b.alisoy@gmail.com
Baku, Azerbaijan
References
- American Diabetes Association. Report of the Expert Committee. Diabetes Care. 2014; (1): 4–19.
- Abyshov N.S., Zakirdzhaev E.D., Zeynalova G.M. et al. Diabetic foot syndrome – actual aspects. Surgery. 2016; (3): 96–102. (In Azer.)
- Balabolkin M.I., Kreminskaya V.M., Klebanova E.M. Role of an oxidizing stress in the pathogenesis of diabetic neuropathy and a possibility of its correction by α-Acidum lipoicum of acid. Problemy endokrinologii. 2005; (3): 22–33. (In Russ.)
- Guryeva I.V., Komelyagina E.Y., Kuzina I.V., Ametov A.S. Diabeticheskaya perifericheskaya sensomotornaya neyropatiya. Patogenez, klinika diagnostika. Metodicheskie rekomendatsii. (Diabetic peripheral sensomotor neuropathy. Pathogenesis, clinic diagnostics. Methodical recommendations.) Moscow: Meditsina. 2008: 24 p. (In Russ.)
- Estrada D.E., Volchuk A., Ramlal T. et al. Stimulation of glucose uptake and translocation of glucose transporters in muscle cells by lipoic acid (thioctic acid). Diabetologie und Stoffwechsel. 1996; 5 (3): 41–45.
- Voinov V.A. Efferentnaya terapiya. Membrannyy plazmaferez. (Efferent therapy. Membrane plasmapheresis.) Moscow: Meditsina. 2002; 270 p. (In Russ.)
- Dzheyranov F.D., Garagezova A.R., Akhmedov M.B., Rakhmani S.A. Some methods of detoxification therapy in the complex treatment of critical lower limb ischemia in patients with diabetes mellitus. Azerbaydzhanskiy meditsinskiy zhurnal. 1996; (4): 113–117. (In Russ.)
- Belmin J., Valensi P. Diabetic neuropathy in elderly patients. What can be done? Drugs Aging. 1996; 8 (6): 416–429. doi: 10.2165/00002512-199608060-00003.
- Karandashov V.I., Petukhov E.B., Zrodnikov B.C. Kvantovaya terapiya. (Quantum Therapy.) Moscow: Meditsina. 2004; 336 p. (In Russ.)
- Yuryev M.F., Boyarinov G.A., Dudina E.V. Ozone-oxygen therapy in the acute period of severe craniocerebral trauma. Revista Ozonoterapia. 2009; 1 (3): 196–197. (In Russ.)
- Thompson G.R. LDL apheresis. Atherosclerosis. 2003; 167: 1–3. doi: 10.1016/s0021-9150(02)00251-4.
- Kotov S.V., Kalinin A.P., Rudakova I.G. Diabeticheskaya nevropatiya. (Diabetic neuropathy.) Moscow: Meditsina. 2000; 40 p. (In Russ.)
- Ziegler D., Ametov A., Barinov A. et al. Oral treatment with alpha-lipoicacid improves symptomatic diabetic polyneuropathy: the SYDNEY 2 trial. Diabetes care. 2006; 29 (11): 2365–2370. doi: 10.2337/dc06-1216.
- Giugliano D., Ceriello A., Paolisso G. Diabetes mellitus, hypertension and cardiovascular pathology: the role of oxydative stress? Metabolism. 1995; 44: 363–368. doi: 10.1016/0026-0495(95)90167-1.
- Dedov I.I. Diabetes mellitus is a problem of the 21st century. Vrach. 2000; (1): 4–5. (In Russ.)
- Guseynov B.A., Akhmedov M.B. Ekstrakorporalnoe ultrafioletovoe obluchenie krovi v prakticheskoy meditsine. (Extracorporeal ultraviolet irradiation of blood in practical medicine.) Baku: Meditsina. 2000; 202 p. (In Russ.)
- Dibirov M.D., Gadzhimuradov R.U., Dibirov A.A. et al. The results of reconstructive surgery for diabetic foot syndrome in gerontological patients. Angiologiya i sosudistaya khirurgiya. 2011; 17 (1): 145–149. (In Russ.)
Supplementary files
