Disaggregation effect of the thrombolytic drug Terrilytin

Thrombolytic properties of terlitin obtained from the fungus Aspergillus terricola, when administered intravenously in animals with experimental thrombi were shown in the works of S.V. Andreev and coworkers, Y.D. Mamedov and coworkers. There are reports about the possibility of obtaining thrombolytic effect when using terlitin orally. Studies of several authors have established a change in the surface and shape of peripheral blood erythrocytes under various influences on the body. This paper presents the results of the experimental justification of the use of terlitin preparation by means of electron microscopic studies of erythrocyte surface.