Email this article Prevalence rate of Helicobacter pylori infection among population of Ryazan region
- Authors: Zhestkova T.V.1, Butov M.A.1, Lymar Y.Y.2, Papkov S.V.1
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Affiliations:
- Ryazan State Medical University
- Center of Molecular Diagnostics of Central Research Institute of Epidemiology
- Issue: Vol 27, No 1 (2019)
- Pages: 35-40
- Section: Original study
- URL: https://journal-vniispk.ru/pavlovj/article/view/11497
- DOI: https://doi.org/10.23888/PAVLOVJ201927135-40
- ID: 11497
Cite item
Abstract
Aim. Determination of the prevalence of Helicobacter pylori (H. pylori) infection among the population of the Ryazan region.
Materials and Methods. 833 individuals (809 adults and 24 children) were examined for presence of IgG class antibodies using the enzyme immunoassay (2017-2018). The criteria for inclusion into the study were: a desire of a patient to undergo examination for the presence of antibodies to H. pylori in blood. Criteria for exclusion: past treatment for helicobacteriosis. The presence of helicobacteriosis was determined by enzyme immunoassay for quantitative detection of IgG class antibodies (anti-H. pylori IgG) using BCM Diagnostics Helicobacter pylori IgG (USA) test system and for qualitative determination of IgG antibodies to H. pylori in blood serum on IMMULITE 2000 (Germany; test IMMULITE® 2000 H. pylori IgG). Sensitivity of the used test systems was >95.0%, specificity >98.0%.
Results. High contamination of adult residents of Ryazan with H. pylori – 65.6% was found (70.6% of males, 64.4% of females). Prevalence of H. pylori infection among adults in 2017 was 64.4% and in 2018 – 70.2%, however, the observed increase in the number of infected individuals was not statistically significant (p<0.05). The highest prevalence of H. pylori infection was observed in individuals ≥40 years of age (67.2%). Gender-related differences in the prevalence of Helicobacter pylori infection were revealed in individuals of 40 years and older. H. pylori infection in males of ≥40 years was 75.2%, against 65.5% in females of the same age (p<0.05). In children of 4-16 years, the share of individuals with positive serological test with anti-H. pylori IgG reached 20.8%. All H. pylori infected children were above 9 years of age. Individuals with positive serological tests received consultation of a gastroenterologist, and on indications underwent additional examination with administration of eradication treatment. In patients with indefinite results the examination was repeated after a week and/or the presence of H. pylori antigen in feces was determined.
Conclusion. The data obtained indicate a high level of infection with H. pylori in the adult population in the Ryazan region – 65.6%. The incidence of detection of anti-H. pylori IgG in the population was maximal in individuals ≥40 years (67.2%).
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##article.viewOnOriginalSite##About the authors
Tatyana V. Zhestkova
Ryazan State Medical University
Author for correspondence.
Email: t-zhestkova@bk.ru
ORCID iD: 0000-0002-6505-1031
SPIN-code: 7403-9954
ResearcherId: A-4929-2019
MD, PhD, Assistant of the Department of Propaedeutic Internal Diseases
Russian Federation, 9, Vysokovoltnaja, Ryazan, 390026Mikhail A. Butov
Ryazan State Medical University
Email: t-zhestkova@bk.ru
ORCID iD: 0000-0003-3402-1128
SPIN-code: 7999-8925
ResearcherId: A-6144-2019
MD, PhD, Professor, Head of the Department of Propaedeutic Internal Diseases
Russian Federation, 9, Vysokovoltnaja, Ryazan, 390026Yulian Yu. Lymar
Center of Molecular Diagnostics of Central Research Institute of Epidemiology
Email: t-zhestkova@bk.ru
ORCID iD: 0000-0001-9689-830X
SPIN-code: 6721-3370
ResearcherId: A-9647-2019
Medical director, Advisor of Clinical and Laboratory Diagnostics
Russian Federation, RyazanSergey V. Papkov
Ryazan State Medical University
Email: t-zhestkova@bk.ru
ORCID iD: 0000-0002-1989-9939
SPIN-code: 3521-7226
ResearcherId: A-7645-2019
MD, PhD, Associate Professor of the Department of Propaedeutic Internal Diseases
Russian Federation, 9, Vysokovoltnaja, Ryazan, 390026References
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