Email this article Condition of platelet factor of hemostasis system in pathogenesis of chronic periodontitis progression
- Authors: Kondyurova E.V.1, Vlasova T.I.1, Trofimov V.A.1, Vlasov A.P.1, Adamchik R.A.1, Akimov V.V.1, Tashina E.A.1
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Affiliations:
- National Research Mordovia State University
- Issue: Vol 27, No 2 (2019)
- Pages: 209-218
- Section: Original study
- URL: https://journal-vniispk.ru/pavlovj/article/view/14545
- DOI: https://doi.org/10.23888/PAVLOVJ2019272209-218
- ID: 14545
Cite item
Abstract
Аim. Тo evaluate the structural and functional condition of platelets as a cellular component of the hemostasis system in chronic generalized periodontitis of different severity, and to establish its role in the progression of the disease.
Materials and Мethods. Clinical studies included 83 patients (47 men and 36 women) with chronic generalized periodontitis, comparable in age and sex, divided into three groups according to the severity of the disease: the first group (n=21) – periodontitis of mild severity; the second group (n=36) – moderate degree of severity; the third group (n=26) – severe periodontitis. Methods of the study included evaluation of the structural and functional characteristics of periodontal tissues, general hygienic condition of the oral cavity, the severity of the inflammatory process according to index parameters; study of microcirculation of periodontal tissues, determination of the evidence of oxidative processes in saliva, blood plasma, platelets, study of lipid composition of platelets.
Results. In chronic generalized periodontitis, pathological changes in the lipid composition of platelet membranes (an increase in the percentage of lysophospholipids and free fatty acids) were associated with systemic activation of oxidative processes and of phospholipase enzyme systems, which was accompanied by an increase in their aggregation activity.The degree of increase in the activity of platelets was associated with the severity of microcirculatory disturbances in the periodontal tissues. The condition of the cellular component of the hemostasis system correlated with the severity of the pathological process in the periodontium. In severe degree of chronic periodontitis, structural and functional changes in platelets were maximal.
Conclusion. In chronic periodontitis, the systemic activation of oxidative processes leads to a modification of the lipid composition of platelet membranes, which contributes to increase in their aggregation activity playing an important role in the induction of hypercoagulation, microcirculation disturbances and progression of inflammation in the periodontal tissues.
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##article.viewOnOriginalSite##About the authors
Evgeniya V. Kondyurova
National Research Mordovia State University
Email: vestnik@rzgmu.ru
ORCID iD: 0000-0001-9586-655X
SPIN-code: 5026-6907
ResearcherId: A-1857-2018
MD, PhD, Associate Professor, Head of the Department of Dentistry of the Medical Institute
Russian Federation, SaranskTat`yana I. Vlasova
National Research Mordovia State University
Author for correspondence.
Email: vap.61@yandex.ru
ORCID iD: 0000-0002-2624-6450
SPIN-code: 5314-3771
ResearcherId: Q-9761-2017
MD, PhD, Professor of the Department of Normal and Pathological Physiology of the Medical Institute
Russian Federation, SaranskVladimir A. Trofimov
National Research Mordovia State University
Email: vestnik@rzgmu.ru
ORCID iD: 0000-0003-1294-1417
SPIN-code: 5131-2399
ResearcherId: С-2221-2017
PhD in Biological Sciences, Professor, Head of the Department of Genetics
Russian Federation, SaranskAleksey P. Vlasov
National Research Mordovia State University
Email: vestnik@rzgmu.ru
ORCID iD: 0000-0003-4731-2952
SPIN-code: 7405-5077
ResearcherId: C-3981-2018
MD, PhD, Professor, Head of the Department of Faculty Surgery
Russian Federation, SaranskRuslan A. Adamchik
National Research Mordovia State University
Email: vestnik@rzgmu.ru
ORCID iD: 0000-0002-3483-288X
SPIN-code: 8313-0634
ResearcherId: G-5414-2018
MD, PhD, Assistant of the Department of Dentistry of the Medical Institute
Russian Federation, SaranskVladimir V. Akimov
National Research Mordovia State University
Email: vestnik@rzgmu.ru
ORCID iD: 0000-0002-5579-3517
SPIN-code: 3413-4532
ResearcherId: Р-2453-2019
PhD Applicant of the Department of Dentistry of the Medical Institute
Russian Federation, SaranskElena A. Tashina
National Research Mordovia State University
Email: vestnik@rzgmu.ru
ORCID iD: 0000-0002-6206-3547
SPIN-code: 5241-1231
ResearcherId: K-6112-2019
PhD-Student of the Department of Faculty Surgery of the Medical Institute
Russian Federation, SaranskReferences
- Kuryakina NV, Kutepova TF. Zabolevaniya paro-donta. Moscow: Med. kn.; N. Novgorod: NGMA; 2000. (In Russ).
- Tsepov LM. K voprosu ob etiologii i patogeneze vospalitel’nykh zabolevaniy parodonta. Parodontolo-giya. 2000;2(16):9-15. (In Russ).
- Chopra R, Patil SR, Mathur Sh. Comparison of cardiovascular disease risk in two main forms of periodontitis. Dental Research Journal. 2012;9(1): 74-9. doi: 10.4103/1735-3327.92953
- Apal’kov IP. Rol’ narusheniy mikrotsirkulyatsii v patogeneze khronicheskogo generalizovannogo pa-rodontita i ikh korrektsiya metodom kombinirovan-noy KVCH-terapii [dissertation]. Saratov; 2004. Available at: https://dlib.rsl.ru/viewer/010026620 88#?page=1. Accessed: 2004 January 4. (In Russ).
- D’Aiuto F, Parkar M, Andreou G, et al. Periodontitis and systemic inflammation: Control of the local infection is associated with a reduction in serum inflammatory markers. Journal of Dental Research. 2004;83(2):156-60. doi: 10.1177/154405910408300214
- Loos BG. Systemic effects of periodontitis. International Journal of Dental Hygiene. 2006;4(1):34-8. doi: 10.1111/j.1601-5037.2006. 00200.x
- Al-Rasheed A. Elevation of white blood cells and platelet counts in patients having chronic periodontitis. The Saudi Dental Journal. 2012;24:17-21. doi: 10.1016/j.sdentj.2011.10.006
- Kazantcev AV, Suetenkov DE. Gender features of platelet aggregation in patients with chronic generalized periodontitis. Parodontologiya. 2014;19(1):7-12. (In Russ).
- Karlash AE, Gorsh•chnova NK. Izmeneniya agre-gatsionnoy aktivnosti trombotsitov pri patologii tkaney parodonta u lits pozhilogo vozrasta s razlichnymi tempami stareniya. Fundamental’nye issledovaniya. 2005;(7):92-3. (In Russ).
- López R, Loos BG, Baelum V. Hematological features in adolescents with periodontitis. Clinical Oral Investigations. 2012;16(4):1209-16. doi:10.1007/ s00784-011-0628-6
- Papapanagiotou D, Nicu EA, Bizzarro S, et al. Pe-riodontitis is associated with platelet activation. Atherosclerosis. 2009;202(2):605-11. doi:10.1016/ j.atherosclerosis. 2008.05.035
- Briskin BS, Bukatko VN. Otsenka sostoyaniya mikrotsirkulyatsii pri ostrom pankreatite metodom lazernoy dopplerovskoy floumetrii. Sibirskoye me-ditsinskoye obozreniye. 2002;4(24):8-10. (In Russ).
- Orekhova LYu, Loboda ES, Yamanidze NA. Estimation of clinical and functional conditions of periodontal microcirculation in terms of the introduction of medical ozone in the treatment of inflammatory periodontal disease. Parodontologiya. 2016; 21(4;81):28-31. (In Russ).
- Park E, Paik H-D, Lee S-M. Combined effects of whey protein hydrolysates and probiotics on oxidative stress induced by an iron-overloaded diet in rats. International Journal of Food Sciences and Nutrition. 2018;69(3):298-307. doi: 10.1080/09637486. 2017.1354977
- Uzbekov MG. Lipid peroxidation and antioxidant systems in mental disorders. Communication V. Russian Society of Psychiatrists. 2017;27(3):106-110. (In Russ).
- Koryakina LB, Pivovarov YuI, Kurilskaya TE, et al. Dysfunction of vascular endothelium at arterial hypertension and coronary disease (literature review). Byulleten' Vostochno-Sibirskogo Nauchnogo Tsentra Sibirskogo Otdeleniya Rossiyskoy Akademii Medi-tsinskikh Nauk. 2013; 2-1(90):165-70. (In Russ).
- Kirichuk VF, Simonyan TV. Narusheniya v mikrotsirkulyatsii i sisteme proteina S u bol’nykh khronicheskim generalizovannym parodontitom. In: Mikrotsirkulyatsiya v klinicheskoy praktike: materialy II Vserossiyskoy nauchnoy konferentsii s mezhdu-narodnym uchastiyem. 2006. P. 42-3. (In Russ).
- Nelayeva AA, Troshina IA. Sostoyaniye perekisnogo okisleniya lipidov v membranakh trombotsitov u bol’nykh IZSD pri ketoatsidoze i korrektsiya vita-minami-antioksidantami. Sakharnyy diabet. 1999; (3):25-30. (In Russ).
- Georgiady NA, Skorikova LA, Gajvoronsky TV. Microcirculation assessment in fabrics parodonta under the influence of treatment. Kuban Scientific Medical Journal. 2012;4(133):121-5. (In Russ).
- Aliyeva MS, Rasulov IM, Magomedov MA, et al. Sovremennyye aspekty etiologii i patogeneza paro-dontita. Izvestiya Dagestanskogo Gosudarstvennogo Pedagogicheskogo Universiteta. Estestvennyye i Tochnyye Nauki. 2013;1(22):25-9. (In Russ).
- Galiullina EF. Modern views on the role of free radical processes as a pathogenetic mechanism triggering periodontal diseases (a review). Problems of Dentistry. 2017;13(1):25-30. (In Russ). doi: 10.18481/2077-7566-2017-13-1-25-30
- Kitaeva VN, Bulkina NV, Polosukhina EN, et al. Investigation of violations of the functional activity of platelets in patients with chronic generalized periodontitis with a view to early diagnosis of periodontal pathology. Saratov Journal of Medical Scientific Research. 2011;17(1):295-7. (In Russ).
- Ponukalina EV, Bulkina NV, Karpenko IN. Disturbances of the vascular thrombocyte mechanism of hemostasis in pathogenesis of the microcirculatory disorders in rapidly progressive periodontitis. Saratov Journal of Medical Scientific Research. 2008;4(1):51-4. (In Russ).
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