Associations of Polymorphisms of NOD2/CARD15, CRP and FTO Genes with Cardiovascular Risk Factors, Damages to Target Organs and Cardiovascular Diseases in Patients with Ulcerative Colitis and Crohn’s Disease
- 作者: Boyakov D.Y.1, Petrov V.S.2, Nikiforov A.A.2, Yakubovskaya A.G.2, Kodyakova O.V.3, Ostyakova V.A.4
-
隶属关系:
- Lipetsk Regional Clinical Hospital
- Ryazan State Medical University
- Regional Clinical Hospital
- Ryazan Regional Clinical Cardiology Dispensary
- 期: 卷 32, 编号 1 (2024)
- 页面: 35-46
- 栏目: Original study
- URL: https://journal-vniispk.ru/pavlovj/article/view/254753
- DOI: https://doi.org/10.17816/PAVLOVJ280037
- ID: 254753
如何引用文章
详细
INTRODUCTION: The role of genetic factors in the development of cardiovascular diseases (CVD) in patients with inflammatory bowel diseases (IBD) is practically unknown.
AIM: To study the frequency of carriage of allelic polymorphous variants of NOD2/CARD15 (3020insC rs5743293, Gly908Arg rs2066845), CRP (+1444C>T rs1130864), FTO (A23525T rs9939609) genes and to perform a comprehensive assessment of damage to the target organs, diastolic myocardial dysfunction of the left ventricle and CVD in patients with ulcerative colitis and Crohn’s disease living in the Ryazan District.
MATERIALS AND METHODS: The study involved 62 patients (41 (66%) women, 40.5 [33.5; 52.25] years old) with IBD (51 patients with ulcerative colitis, 11 patients with Crohn’s disease) in whom 3020insC and Gly908Arg polymorphisms in CARD15 (NOD2) gene, C1444T in CRP gene and А23525Т in FTO gene were determined using allele-specific polymerase chain reaction. After that, the frequency of carriage of their allelic variants and association with CVRFs, damage to the target organs (through evaluation of the arterial stiffness, pulse pressure, hypertrophy of the left ventricular myocardium, ankle-brachial index) and CVDs was evaluated.
RESULTS: According to the aims of the study, the frequency of carriage of allelic polymorphic variants of genes was determined: 3020insC in gene CARD15 (NOD2) rs5743293 85.5% — homozygote for allele 1, 14,5% — heterozygote; Gly908Arg in gene CARD15 (NOD2) rs2066845 93.5% — homozygote for allele 1, 6.5% — heterozygote; C1444T in gene CRP rs1130864 50% — homozygote for allele 1, 41.9% — heterozygote, 8.1% — homozygote for allele 2; А23525Т in gene FTO rs9939609 38.7% — homozygote for allele 1, 38.7% — heterozygote, 22.6% — homozygote for allele 2. The prevalence of arterial hypertension was 31%, of obesity by body mass index — 18%, by waist circumference — 29%, and of dyslipidemia — 53%. Statistically significant associations were found between: 1) hypercholesterolemia and Gly908Arg polymorphism in gene CARD15 (NOD2) rs2066845 (÷2 = 6.005; p = 0.014), 2) family history of early CVD and 3020insC polymorphism in gene CARD15 (NOD2) rs2066845 (÷2 = 4.561; p = 0.033), 3) arterial hypertension and 3020insC polymorphism in genеCARD15 (NOD2) rs5743293 (÷2 = 4.65; p = 0.031).
CONCLUSION: The prevalence of arterial hypertension, obesity and dyslipidemia in patients with IBD is considerably lower in the given study than in the individuals of comparable age in the epidemiological MERIDIAN-RO study conducted in the Ryazan region. Statistically significant associations were found between the studied polymorphisms and hypercholesterolemia, family history of early cardiovascular diseases and arterial hypertension.
作者简介
Dmitriy Boyakov
Lipetsk Regional Clinical Hospital
编辑信件的主要联系方式.
Email: boyakov96@gmail.com
ORCID iD: 0000-0003-4041-5676
俄罗斯联邦, Lipetsk
Vadim Petrov
Ryazan State Medical University
Email: dr.vspetrov@gmail.com
ORCID iD: 0000-0001-8631-8826
MD, Dr. Sci. (Med.), Associate Professor
俄罗斯联邦, RyazanAleksandr Nikiforov
Ryazan State Medical University
Email: alnik003@yandex.ru
ORCID iD: 0000-0003-0866-9705
MD, Cand. Sci. (Med.), Associate Professor
俄罗斯联邦, RyazanAlina Yakubovskaya
Ryazan State Medical University
Email: yakubgreg@mail.ru
ORCID iD: 0000-0002-6994-1947
MD, Cand. Sci. (Med.)
俄罗斯联邦, RyazanOl'ga Kodyakova
Regional Clinical Hospital
Email: gst.kodyakova@yandex.ru
ORCID iD: 0000-0002-2141-1146
俄罗斯联邦, Ryazan
Veronika Ostyakova
Ryazan Regional Clinical Cardiology Dispensary
Email: Nika111213@yandex.ru
ORCID iD: 0000-0003-3451-5355
俄罗斯联邦, Ryazan
参考
- Cainzos–Achirica M, Glassner K, Zawahir HS, et al. Inflammatory Bowel Disease and Atherosclerotic Cardiovascular Disease: JACC Review Topic of the Week. J Am Coll Cardiol. 2020;76(24):2895–905. doi: 10.1016/j.jacc.2020.10.027
- Wu G–C, Leng R–X, Lu Q, et al. Subclinical Atherosclerosis in Patients With Inflammatory Bowel Diseases: A Systematic Review and Meta-Analysis. Angiology. 2017;68(5):447–61. doi: 10.1177/0003319716652031
- Visseren FLJ, Mach F, Smulders YM, et al.; ESC National Cardiac Societies; ESC Scientific Document Group. 2021 ESC Guidelines on cardiovascular disease prevention in clinical practice. Eur Heart J. 2021;42(34):3227–337. doi: 10.1093/eurheartj/ehab484
- Zeng Z, Mukherjee A, Zhang H. From Genetics to Epigenetics, Roles of Epigenetics in Inflammatory Bowel Disease. Front Genet. 2019; 10:1017. doi: 10.3389/fgene.2019.01017
- Petrov VS, Nikiforov AA, Smirnova EA. Polymorphism of CYP3A4 isoenzyme gene in patients with chronic rheumatic heart disease. I. P. Pavlov Russian Medical Biological Herald. 2021;29(2):239–44. (In Russ). doi: 10.17816/PAVLOVJ65126
- Petrov VS, Nikiforov АА, Smirnova EA. Polymorphism of toll-like receptors-2 in patients with chronic rheumatic heart disease. Nauka Molodykh (Eruditio Juvenium). 2021;9(1):51–8. (In Russ). doi: 10.23888/HMJ20219151-58
- Schulkin AV, Filimonova AA. Role of free radical oxidation, hypoxia and their correction in COVID-19 pathogenesis. Therapy. 2020;(5):187–94. (In Russ). doi: 10.18565/therapy.2020.5.187-194
- Mitchell JP, Carmody RJ. NF-κB and the Transcriptional Control of Inflammation. Int Rev Cell Mol Biol. 2018;335:41–84. doi: 10.1016/bs.ircmb.2017.07.007
- Dragasevic S, Stankovic B, Kotur N, et al. Metabolic Syndrome in Inflammatory Bowel Disease: Association with Genetic Markers of Obesity and Inflammation. Metab Syndr Relat Disord. 2020;18(1): 31–8. doi: 10.1089/met.2019.0090
- Liu C, Mou S, Pan C. The FTO gene rs9939609 polymorphism predicts risk of cardiovascular disease: a systematic review and meta-analysis. PLoS One. 2013;8(8):e71901. doi: 10.1371/journal.pone.0071901
- Galluzzo S, Patti G, Dicuonzo G, et al. Association between NOD2/CARD15 polymorphisms and coronary artery disease: a case-control study. Hum Immunol. 2011;72(8):636–40. doi: 10.1016/ j.humimm.2011.04.005
- Yazdanyar S, Nordestgaard BG. NOD2/CARD15 genotype, cardiovascular disease and cancer in 43,600 individuals from the general population. J Intern Med. 2010;268(2):162–70. doi: 10.1111/j.1365-2796.2010.02232.x
- El Mokhtari NE, Ott SJ, Nebel A, et al. Role of NOD2/CARD15 in coronary heart disease. BMC Genet. 2007;8:76. doi: 10.1186/1471-2156-8-76
- Yakubovskaya AG, Nizov AA, Baranov VS, et al. NOD2/CARD15 and TNF-α gene polymorphism in patients with ulcerative colitis in Ryazan region. Vestnik Sovremennoi Klinicheskoi Mediciny. 2013; 6(4):17–21. (In Russ).
- Singh S, Kullo IJ, Pardi DS, et al. Epidemiology, risk factors and management of cardiovascular diseases in IBD. Nat Rev Gastro-enterol Hepatol. 2015;12(1):26–35. doi: 10.1038/nrgastro.2014.202
- Filippov EV, Vorobyev AN, Dobrynina NV, at al. Adverse cardiovascular outcomes and their relationship with risk factors according to the prospective study MERIDIAN-RO. Russian Journal of Cardiology. 2019;24(6):42–8. (In Russ). doi: 10.15829/1560-4071- 2019-6-42-48
- Vasyuk YuA, Ivanova SV, Shkolnik EL, etal. Consensus of Russian experts on the evaluation of arterial stiffness in clinical practice. Cardiovascular Therapy and Prevention. 2016;15(2):4–19. (In Russ). doi: 10.15829/1728-8800-2016-2-4-19
补充文件
