电邮这篇文章 Application of enterosorbent on the basis of montmorillonite in acute diarrhea (experimental study)
- 作者: Tishin A.N.1, Pokrovskii M.V.2, Tishina O.М.3, Sernov L.N.2, Stepchenko A.A.4
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隶属关系:
- Orel Regional Clinical Hospital
- Belgorod National Research University
- Medical-sanitary unit of the Administration of Ministry of Internal Affairs of Russia of the Orel Region
- Kursk State Medical University
- 期: 卷 25, 编号 4 (2017)
- 页面: 551-564
- 栏目: Pharmacology, clinical pharmacology
- URL: https://journal-vniispk.ru/pavlovj/article/view/7731
- DOI: https://doi.org/10.23888/PAVLOVJ20174551-564
- ID: 7731
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详细
Aim. To study the antidiarrheal activity of enterosorbent on the basis of montmorillonite on the model of serotonin-induced diarrhea.
Materials and Methods. The study was conducted on laboratory mice of both sexes, acute diarrhea was induced by intraperitoneal injection of serotonin hydrochloride at the dose of 0.32 mg/kg, enterosorbent was introduced orally in the form of aqueous suspension in a wide range of doses 30 minutes before introduction of serotonin. Within 4 hours, the time of onset of diarrhea, the number of defecations, the fluid content in fecal masses were taken into account. Morphological examination of the small intestine was carried out.
Results. introduction of serotonin led to diarrhea in 100% of animals within 12.8±1.2 minutes, the number of defecations increased 2.5 times as compared to the intact animals and was 19.5±0.5 times in 4 hours, the fecal masses were predominantly semi-liquid and liquid. Use of enterosorbent coded Crim_04 at the maximum dose led to a delay in diarrhea up to 73.6±4.1 minutes, the number of defecations decreased to 9.4±0.1 with a significant solidification of feces. The antidiarrheal effect of enterosorbent was confirmed morphologically.
Conclusions. Enterosorbent on the basis of montmorillonite with laboratory code Crim_04 possesses a dose-dependent antidiarrheal effect in modeling of serotonin-induced diarrhea.
作者简介
A. Tishin
Orel Regional Clinical Hospital
编辑信件的主要联系方式.
Email: antoshatishin@yandex.ru
ORCID iD: 0000-0002-8286-8967
SPIN 代码: 3250-6576
therapist
俄罗斯联邦, Pobedy Boulevard, 10, 302028, OrelM. Pokrovskii
Belgorod National Research University
Email: antoshatishin@yandex.ru
SPIN 代码: 9201-3580
MD, Grand PhD, Professor, Head of the Department of Pharmacology
俄罗斯联邦, Pobeda str., 85, 308015, BelgorodO. Tishina
Medical-sanitary unit of the Administration of Ministry of Internal Affairs of Russia of the Orel Region
Email: antoshatishin@yandex.ru
SPIN 代码: 7492-3519
therapist of Medical-sanitary unit of the Administration of Ministry of Internal Affairs of Russia of the Orel Region
俄罗斯联邦, Saltykov-Shchedrin str., 37, 302028, OrelL. Sernov
Belgorod National Research University
Email: antoshatishin@yandex.ru
SPIN 代码: 5241-1276
MD, Grand PhD, Professor
俄罗斯联邦, Pobeda str., 85, 308015, BelgorodA. Stepchenko
Kursk State Medical University
Email: antoshatishin@yandex.ru
SPIN 代码: 5747-3948
MD, Grand PhD, Associate Professor
俄罗斯联邦, K. Marx str., 3, 305041, Kursk参考
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