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Post a Comment The stomach as the target organ of celiac disease
- Authors: Novikova V.P.1, Shapovalova N.S.1, Revnova M.O.1, Melnikova V.F.1, Lapin S.V.2, Guseva V.I.2, Gurina O.P.1, Dementieva E.A.1, Klikunova K.A.1
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Affiliations:
- St. Petersburg State Pediatric Medical University
- Рavlov First Saint Petersburg State Medical University, Ministry of Healthcare of the Russian Federation
- Issue: Vol 9, No 4 (2018)
- Pages: 64-72
- Section: Articles
- URL: https://journal-vniispk.ru/pediatr/article/view/10406
- DOI: https://doi.org/10.17816/PED9464-72
- ID: 10406
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Abstract
The aim of this study was to observe the features of chronic gastritis in children with celiac disease (СD).
Materials and methods. 176 children with chronic gastritis (CG) aged from 3 to 16 years were examined. Group I consisted 58 child ren with CG and newly diagnosed CD not adherent to the gluten-free diet (GFD), group II consisted 49 children with CG and CD, adherent to the GFD. In the group III of comparisons were 69 children with CG and excluded CD. The exa mination included serological, morphological methods to confirm or exclude CD. The histological examination of the biopsy specimens of the gastric mucosa, the determination of antiparietal antibodies by the method of iIFR and ELISA (antibodies to Castle’s intrinsic factor and Anti-H+/K+ ATPase antibodies) were carried out.
Results. Helicobacter pylori infection was diagnosed in vast majority of patients in all groups. Autoantibodies to the gastric mucosa were found in every tenth patient in groups I and III, and did not occur in group II. In group II statistically significant the etiology of gastritis remained not determined. Endoscopically the gastric mucosa in groups I and II often remained intact. Accor ding to the morphological study in groups I and II, the pathological process was more often localized in the body of the stomach, and in group III in the antrum. Autoimmune gastritis is presented in groups without a statistically significant difference.
Conclusion. Chronic gastritis is a frequent co-morbid pathology in СD, and it is also not uncommon in these patients. Data of endoscopy in children, regardless of diet, does not reflect the complete picture of CG. All children with CD, regardless of compliance with GFD, are recommended to take biopsy specimens of the gastric mucosa for histological examination in order to exclude CG, and in case of detecting atrophic changes in the gastric mucosa to define the antiparietal antibodies.
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##article.viewOnOriginalSite##About the authors
Valeria P. Novikova
St. Petersburg State Pediatric Medical University
Author for correspondence.
Email: novikova-vp@mail.ru
MD, PhD, Dr Mеd Sci, Professor, Head, Research Center
Russian Federation, Saint PetersburgNatalia S. Shapovalova
St. Petersburg State Pediatric Medical University
Email: natasunday@mail.ru
Junior Researcher, Research Center
Russian Federation, Saint PetersburgMaria O. Revnova
St. Petersburg State Pediatric Medical University
Email: natasunday@mail.ru
MD, PhD, Dr Mеd Sci, Professor, Head, AF Tour Department of Outpatient Pediatrics
Russian Federation, Saint PetersburgValentina F. Melnikova
St. Petersburg State Pediatric Medical University
Email: rrmd99@mail.ru
MD, PhD, Dr Mеd Sci, Professor, Department of Pathological Anatomy at the Rate of Forensic Medicine
Russian Federation, Saint PetersburgSergey V. Lapin
Рavlov First Saint Petersburg State Medical University, Ministry of Healthcare of the Russian Federation
Email: svlapin@mail.ru
MD, PhD, Associate Professor, Head, Laboratory for the Diagnosis of Autoimmune Diseases
Russian Federation, Saint PetersburgVeronika I. Guseva
Рavlov First Saint Petersburg State Medical University, Ministry of Healthcare of the Russian Federation
Email: nika_pion@mail.ru
Laboratory Doctor, Laboratory for the Diagnosis of Autoimmune Diseases
Russian Federation, Saint PetersburgOlga P. Gurina
St. Petersburg State Pediatric Medical University
Email: ol.gurina@yandex.ru
MD, PhD, Senior Researcher, Research Center
Russian Federation, Saint PetersburgElena A. Dementieva
St. Petersburg State Pediatric Medical University
Email: zorra2@yandex.ru
Junior Researcher, Research Center
Russian Federation, Saint PetersburgKsenia A. Klikunova
St. Petersburg State Pediatric Medical University
Email: kliksa@gmail.com
PhD, Associate Professor, Department of Medical Physics
Russian Federation, Saint PetersburgReferences
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