Email this article 
Post a Comment The availability of vitamin D in children of the first year of life with food allergies residing in conditions of military conflict in Donbass
- Authors: Nalyotov A.V.1, Shapchenko T.I.1, Svistunova N.A.1, Vakulenko M.V.1
-
Affiliations:
- State Educational Institution of Higher Professional Education “M. Gorky Donetsk National Medical University”
- Issue: Vol 11, No 2 (2020)
- Pages: 51-56
- Section: Original studies
- URL: https://journal-vniispk.ru/pediatr/article/view/120344
- DOI: https://doi.org/10.17816/PED11251-56
- ID: 120344
Cite item
Full Text
Abstract
The problem of vitamin D deficiency is one of the most actual today. According to numerous clinical studies, its insufficiency of this micronutrient is registered in half of the world’s population.
Aim of the study. To study the provision of vitamin D in infants, suffering from food allergy and living in the Donbass in a military conflict.
Materials and methods. 105 infants living in the Donetsk People’s Republic suffering from food allergy were examined. The level of vitamin D in serum in these patients was studied by determining serum levels of 25(OH)D.
Results and discussion. Insufficient vitamin D levels were found in 57.1 ± 4.8% infants with food allergy, which was significantly higher (р < 0.05) compared to healthy children (12.5 ± 5.2%). At the same time, children with food allergies, long-term living near the region of active hostilities, statistically significant (р < 0.001) often had a reduced level of vitamin D. It was found that in the group of patients with low level of vitamin D polyvalent food allergy was determined statistically significantly more common compared to the group of patients with normal level of vitamin D.
Conclusion. Infants, suffering from food allergy and living in the Donetsk People’s Republic in a long-term military conflict are characterized by a decrease in vitamin D level, which may play a role in the formation of the immune response, the development of clinical symptoms of pathology and disrupt the development of tolerance to the food allergens.
Keywords
Full Text
##article.viewOnOriginalSite##About the authors
Andrew V. Nalyotov
State Educational Institution of Higher Professional Education “M. Gorky Donetsk National Medical University”
Author for correspondence.
Email: nalyotov-a@mail.ru
MD, PhD, Dr Med Sci, Associate Professor, Head Department of Pediatrics No. 2
Russian Federation, DonetskTatyana I. Shapchenko
State Educational Institution of Higher Professional Education “M. Gorky Donetsk National Medical University”
Email: shapchenko.tatyanka@mail.ru
Assistant Professor, Department of Pediatrics No. 2
Russian Federation, DonetskNatalia A. Svistunova
State Educational Institution of Higher Professional Education “M. Gorky Donetsk National Medical University”
Email: natasha.svist168@gmail.com
Resident Doctor, Department of Pediatrics No. 2
Russian Federation, DonetskMaxim V. Vakulenko
State Educational Institution of Higher Professional Education “M. Gorky Donetsk National Medical University”
Email: vakolenkomax@mail.ru
MD, PhD, Associate Professor, Department of Pediatric Surgery and Anesthesiology
Russian Federation, DonetskReferences
- Захарова И.Н., Климов Л.Я., Курьянинова В.А. и др. Аллергия на холекальциферол: мифы и реальность (результаты общероссийских многоцентровых исследований) // Педиатрия. Consilium Medicum – 2019. – № 1. – С. 21–28. [Zaharova IN, Klimov LJa, Kur’janinova VA, et al. Allergy to cholecalciferol: myths and reality (results of all-Russian multicenter studies). Pediatrija. Consilium Medicum. 2019;(1):21–28. (in Russ.)]. doi: 10.26442/26586630.2019.1.190258.
- Макарова С.Г. Двенадцать мифов о пищевой аллергии у детей // Вопросы современной педиатрии. – 2017. – Т. 16. – № 16. – С. 522–528. [Makarova S.G. Twelve myths about food Allergy in children. Voprosy sovremennoj pediatrii. 2017;16(6):522-528. (in Russ.)]
- Макарова С.Г., Намазова-Баранова Л. С. Витамины в профилактике и лечении аллергических болезней у детей // Педиатрическая фармакология. – 2015. – Т. 12. – № 5. – С. 562–572. [Makarova S.G., Namazova-Baranova L.S. Vitamins in the prevention and treatment of allergic diseases in children. Pediatric pharmacology. 2015;12(5):562-572. (In Russ.)]. https://doi.org/10.15690/pf.v12i5.1459.
- Налетов А.В., Вьюниченко Ю.С., Коктышев И.В. Оценка качества жизни детей с синдромом раздраженного кишечника, проживающих в условиях военного конфликта в Донбассе // Университетская клиника. – 2018. — Т. 2. – № 27. – С. 12–16. [Naletov A.V., V’junichenko Ju.S., Koktyshev I.V. Assessment of the quality of life of children with irritable bowel syndrome living in the conditions of the military conflict in Donbass. Universitetskaja klinika. 2018;2(27):12-16. (In Russ.)]
- Ревякина В.А. Клинические проявления и современные направления в терапии гастроинтестинальных проявлений аллергии // Медицинский оппонент. – 2018. – Т. 1. – № 3. – С. 54–58. [Revjakina V.A. Clinical manifestations and current trends in the treatment of gastrointestinal manifestations of аllergy. Medical opponent. 2018;1(3):54-58. (In Russ.)]
- Захарова И.Н., Боровик Т.Э., Вахлова И.В., и др. Национальная программа «Недостаточность витамина D у детей и подростков Российской Федерации: Н35 современные подходы к коррекции». – М.: ПедиатрЪ, 2018. – 96 с. [Zakharova IN, Borovik TE, Vakhlova IV, et al. Natsional’naya programma “Nedostatochnost’ vitamina D u detey i podrostkov Rossiyskoy Federatsii: N35 sovremennye podkhody k korrektsii”. Moscow: Pediatr; 2018. 96 p. (In Russ.)]
- Berraies A, Hamzaoui K, Hamzaoui A. Link between vitamin D and airway remodeling. J. Asthma Allergy. 2014;7:23-30.
- Kim KW, Ober C. Lessons learned from GWAS of asthma. Allergy Asthma Immunol. Res. 2019;11(2):170-187.
- Martineau AR, Jolliffe DA, Greenberg L, et al. Vitamin D supplementation to prevent acute respiratory infections: individual participant datameta-analysis. Health Technol Assess. 2019;23(2):1-44.
- Mesquita KdeC, Igreja AC, Costa IM. Atopic dermatitis and vitamin D: facts and controversies. An Bras Dermatol. 2013;88(6):945-953.
Supplementary files
