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Post a Comment The effect of peptide bioregulators on the resistance of rats to cold-stress factor
- Authors: Ganapolsky V.P.1, Agafonov P.V.1, Matytsyn V.O.1,2
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Affiliations:
- Kirov Military Medical Academy
- Academisian I.P. Pavlov First St. Petersburg State Medical University
- Issue: Vol 13, No 6 (2022)
- Pages: 85-96
- Section: Reviews
- URL: https://journal-vniispk.ru/pediatr/article/view/133044
- DOI: https://doi.org/10.17816/PED13685-96
- ID: 133044
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Abstract
BACKGROUND: Biologically active regulatory peptides are the drugs of new type that act selectively on targets, with having no significant side effects.
AIM: The aim of the study was to study the potential effect of peptide preparations Cortexin® and Semax® on the resistance of the rat organism to the cold stress factor in the model of cold stress maladaptation.
MATERIALS AND METHODS: White outbred male rats were injected intraperitoneally twice daily with placebo (n = 30), Cortexin® 5 mg/kg (n = 30) or Semax® 0.3 mg/kg (n = 30). Three days after the start of the injection course, the cold-stress effect was simulated in the climate chamber (Feutron, Germany) by cooling the air to 5°C at a relative humidity of 75–80%.
RESULTS: The use of RP significantly increased the duration of the rectal temperature plateau-period within 35°C (moderate hypothermia): in animals of the Cortexin® group from 10 days to 12 days, and in animals of the Semax® group, from 10 to 14 days. Cortexin® demonstrated moderate immunomodulatory properties, and Semax® had a more pronounced immunomodulatory effect. Both preparations showed a stress-protective effect. The use of regulatory peptides provided to delay the decrease in the rat general motor activity and exploratory behavior which develops under the influence of a simulated cold-stress factor. A slower rate of decrease in the swimming time of rats under the influence of regulatory peptides was registrated.
CONCLUSIONS: The meteoadaptogenic, stress-protective and nootropic effects of the regulatory peptides Cortexin® and Semax® were confirmed in rats on the model of cold-stress maladaptation.
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##article.viewOnOriginalSite##About the authors
Vyacheslav P. Ganapolsky
Kirov Military Medical Academy
Email: ganvp@mail.ru
MD, PhD, Dr. Sci. (Med.), Head of the Research Department of the Habitability, Research Center
Russian Federation, Saint PetersburgPavel V. Agafonov
Kirov Military Medical Academy
Author for correspondence.
Email: agafonov23@yandex.ru
MD, PhD, Cand. Sci. (Med.), Senior Lecturer at the Department of Military Field Therapy
Russian Federation, Saint PetersburgVyacheslav O. Matytsyn
Kirov Military Medical Academy; Academisian I.P. Pavlov First St. Petersburg State Medical University
Email: matitsin@list.ru
MD, PhD, Cand. Sci. (Med.), Senior Research Associate, Research Department of the Habitability, Research Center; Assistant Professor, Department of Normal Physiology
Russian Federation, Saint Petersburg; Saint PetersburgReferences
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