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Post a Comment Intestinal microflora in children with secondary hyperoxaluria and allergic respiratory diseases
- Authors: Obukhova A.N.1, Khaletskaya O.V.1, Shchelchkova N.A.1, Seliverstov A.N.1, Shirokova I.Y.1, Chekanina O.M.1, Ermolina E.V.1
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Affiliations:
- Privolzhsky Research Medical University
- Issue: Vol 14, No 6 (2023)
- Pages: 15-23
- Section: Original studies
- URL: https://journal-vniispk.ru/pediatr/article/view/256905
- DOI: https://doi.org/10.17816/PED626376
- ID: 256905
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Abstract
BACKGROUND: The intestinal microflora has an important role in the human body by influencing metabolic processes. It is proved that changes in intestinal microbiocenosis can cause the development of diseases. To date, the state of the intestinal microflora in children with impaired oxalate metabolism in combination with allergic pathology remains insufficiently studied.
AIM: The aim of the research was to study the intestinal microflora in children with secondary hyperoxaluria and allergic respiratory diseases.
MATERIALS AND METHODS: We examined 50 children aged 3 to 7 years with a diagnosis of secondary hyperoxaluria. The children were divided into two groups: group I — children with secondary hyperoxaluria and allergic respiratory diseases (n = 21); group II — children with secondary hyperoxaluria without allergic respiratory diseases (n = 29). All patients underwent a study of the state of intestinal microflora using fecal analysis by real-time PCR with fluorescence detection. The high-performance liquid chromatography method was used to determine the level of short-chain fatty acids in the feces of patients with secondary hyperoxaluria and allergic respiratory diseases.
RESULTS: The level of oxaluria is higher in patients with a combination of secondary hyperoxaluria and allergic respiratory diseases than with isolated secondary hyperoxaluria (p = 0.018). Changes in the intestinal microflora were detected in all patients with secondary hyperoxaluria (100%, n = 50). Сhildren with secondary hyperoxaluria and allergic respiratory diseases had a lower intestinal content of Faecalibacterium prausnitzii (p = 0.004) and Ruminococcus spp. (p = 0.017), there were also violations of the metabolic activity of bacteria, manifested by a decrease in the concentration of monocarboxylic acids: acetic (0.18 ± 0.09), butyric (0.006 ± 0.003), valerian (0.003 ± 0.001).
CONCLUSIONS: Secondary hyperoxaluria in children aged 3 to 7 years is combined with a violation of the intestinal microflora, more pronounced in allergic respiratory diseases.
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##article.viewOnOriginalSite##About the authors
Anna N. Obukhova
Privolzhsky Research Medical University
Author for correspondence.
Email: obukhovaanna@mail.ru
ORCID iD: 0000-0002-8070-5785
SPIN-code: 4682-5309
MD, PhD, Assistant Professor, Department of Hospital Pediatrics
Russian Federation, Nizhny NovgorodOlga V. Khaletskaya
Privolzhsky Research Medical University
Email: ovh14@mail.ru
ORCID iD: 0000-0002-8531-3174
SPIN-code: 9342-9261
MD, PhD, Dr. Sci. (Medicine), Professor, Head, Department of Hospital Pediatrics
Russian Federation, Nizhny NovgorodNatalia A. Shchelchkova
Privolzhsky Research Medical University
Email: n.shchelchkova@mail.ru
ORCID iD: 0000-0001-6398-4746
SPIN-code: 5248-7529
PhD, Associate Professor, Head, Central Research Laboratory of the Institute of Fundamental Medicine, Department of Normal Physiology named after N.Y. Belenkov
Russian Federation, Nizhny NovgorodAndrey N. Seliverstov
Privolzhsky Research Medical University
Email: andselisk@gmail.com
ORCID iD: 0000-0002-2602-6247
SPIN-code: 9585-1623
Researcher, Central Research Laboratory of the Institute of Fundamental Medicine
Russian Federation, Nizhny NovgorodIrina Yu. Shirokova
Privolzhsky Research Medical University
Email: shirokova.i@yandex.ru
ORCID iD: 0000-0002-8387-6344
SPIN-code: 9123-1213
MD, PhD, Associate Professor, Head, Bacteriological Laboratory of the Research Institute of Preventive Medicine of the University Clinic of the Federal State Educational Institution, Department of Epidemiology, Microbiology and Evidence-Based Medicine
Russian Federation, Nizhny NovgorodOksana M. Chekanina
Privolzhsky Research Medical University
Email: oksana-chekanina@mail.ru
ORCID iD: 0000-0002-6040-9866
SPIN-code: 9217-9430
Doctor of clinical and laboratory diagnostics, Research Institute of Preventive Medicine of the University Clinic
Russian Federation, Nizhny NovgorodElena V. Ermolina
Privolzhsky Research Medical University
Email: ermonay@gmail.com
ORCID iD: 0000-0002-6349-0890
SPIN-code: 4192-2480
Biologist, Research Institute of Preventive Medicine of the University Clinic
Russian Federation, Nizhny NovgorodReferences
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