Breathing disorders during sleep in premature infants with broncopulmonary dysplasia and pulmonary hypertension
- Authors: Solomakha A.Y.1, Petrova N.A.1, Ivanov D.O.2, Sviryaev Y.V.1,3
-
Affiliations:
- Almazov National Medical Research Center
- St Petersburg State Pediatric Medical University
- Sechenov institute of evolutionary physiology and biochemistry RAS
- Issue: Vol 8, No 6 (2017)
- Pages: 5-10
- Section: Articles
- URL: https://journal-vniispk.ru/pediatr/article/view/7869
- DOI: https://doi.org/10.17816/PED865-10
- ID: 7869
Cite item
Full Text
Abstract
Infants with severe and moderate bronchopulmonary dysplasia (BPD) are characterized by long-term persistence of apnea of prematurity, mainly central genesis, and more significant decrease of ЅрО2. The aim of our study was to assess the character and severity of breathing disorders during sleep in infants the first year of life, born prematurely and having BPD complicated by PH. Were examined 40 infants who were born at 23-31 weeks of gestation, weight at birth less than 1700 g. 31 infants had BPD (mild form was diagnosed in 9 infants, moderate form – in 12 infants and severe form – in 10 infants), 11 infants had BPD complicated by PH. Patients were divided into 3 groups. The first group was made up of the infants without BPD. The second group includes infants with BPD, and 3 group was made up of the infants with BPD complicated by PH. Cardiorespiratory monitoring was performed immediately before discharge from hospital (35-43 weeks post-menstrual age) (infants had not been routine monitored for at list 5 days and had not been received oxygen for at list 8 days). We used “The brief screening questionnaire for infants with sleep problems”, developed by A. Sadeh (author's permission to use the questionnaires was received), as the screening of disorders of sleep in infants. The result was obtained the comparative characteristics of cardiorespiratory indices in the groups of infants and evaluated the character and severity of breathing disorders during sleep, made testing applications screening questionnaire.
Full Text
##article.viewOnOriginalSite##About the authors
Anna Yu. Solomakha
Almazov National Medical Research Center
Author for correspondence.
Email: anka.solomaha@yandex.ru
MD, post-graduate student, pediatrician, Department of Pediatric Diseases
Russian Federation, Saint PetersburgNatalia A. Petrova
Almazov National Medical Research Center
Email: natalja5@yandex.ru
MD, PhD, neonatologist, Head of Physiology and Pathology of Newborns Laboratory
Russian Federation, Saint PetersburgDmitry O. Ivanov
St Petersburg State Pediatric Medical University
Email: doivanov@yandex.ru
MD, PhD, Dr Med Sci, Professor, Rector
Russian Federation, Saint PetersburgYurii V. Sviryaev
Almazov National Medical Research Center; Sechenov institute of evolutionary physiology and biochemistry RAS
Email: yusvyr@yandex.ru
MD, PhD, Dr Med Sci, cardiologist, Head of Sleep Medicine Laboratory
Saint Petersburg; Saint PetersburgReferences
- Геппе Н.А., Розинова Н.Н., Волков И.К., и др. Новая рабочая классификация бронхолегочных заболеваний у детей // Доктор.Ру. – 2009. – № 1. – С. 7–13. [Geppe NA, Rozinova NN, Volkov IK, et al. New classification of bronchopulmonary diseases in children. Doctor.ru. 2009;(1):7-13. (In Russ.)]
- Петрова Н.А. Особенности регуляции дыхания у новорожденных детей с формирующейся хронической бронхолегочной патологией: Автореф. дис. … канд. мед. наук. – СПб., 2010. [Petrova NA. The regulation of respiration in newborns with developing chronic bronchopulmonary pathology. [dissertation] Saint Petersburg; 2010. (In Russ.)]
- Шабалов Н.П. Неонатология: учебное пособие. Т. 1. – М., 2004. [Shabalov NP. Neonatology: tutorial. Book 1. Moscow; 2004. (In Russ.)]
- Abman SH, Hansmann G, Archer SL, et al. Pediatric Pulmonary Hypertension: Guidelines From the American Heart Association and American Thoracic Society. Circulation. 2015;132(21):2037-2099. doi: 10.1161/CIR.0000000000000329.
- Ali Z, Schmidt P, Dodd J, Jeppesen DL. Predictors of bronchopulmonary dysplasia and pulmonary hypertension in newborn children. Dan Med J. 2013;60(8): A4688.
- Ambalavanan N, Mourani P. Pulmonary hypertension in bronchopulmonary dysplasia. Birth Defects Res A Clin Mol Teratol. 2014;100(3):240-246. doi: 10.1002/bdra.23241.
- Berry RB, Budhiraja R, Gottlieb DJ, et al. Rules for scoring respiratory events in sleep: update of the 2007 AASM Manual for the Scoring of Sleep and Associated Events. Deliberations of the Sleep Apnea Definitions Task Force of the American Academy of Sleep Medicine. J Clin Sleep Med. 2012;8(5):597-619. doi: 10.5664/jcsm.2172.
- Cotten CM, Oh W, McDonald S, et al. Prolonged hospital stay for extremely premature infants: risk factors, center differences, and the impact of mortality on selecting a best-performing center. J Perinatol. 2005;25(10):650-655. doi: 10.1038/sj.jp.7211369.
- Dayyat E, Kheirandish-Gozal L, Gozal D. Childhood Obstructive Sleep Apnea: One or Two Distinct Disease Entities? Sleep Med Clin. 2007;2(3):433-444. doi: 10.1016/j.jsmc.2007.05.004.
- Thoracic Society of A, New Z, Fitzgerald DA, et al. Infants with chronic neonatal lung disease: recommendations for the use of home oxygen therapy. Med J Aust. 2008;189(10):578-582.
- Guilleminault C, Tilkian A, Dement WC. The sleep apnea syndromes. Annu Rev Med. 1976;27:465-484. doi: 10.1146/annurev.me.27.020176.002341.
- Hack M, Friedman H, Fanaroff AA. Outcomes of extremely low birth weight infants. Pediatrics. 1996;98(5):931-937.
- Jobe AH, Bancalari E. Bronchopulmonary dysplasia. Am J Respir Crit Care Med. 2001;163(7):1723-1729. doi: 10.1164/ajrccm.163.7.2011060.
- Katz-Salamon M, Gerner EM, Jonsson B, Lagercrantz H. Early motor and mental development in very preterm infants with chronic lung disease. Arch Dis Child Fetal Neonatal Ed. 2000;83(1):F1-6. doi: 10.1136/fn.83.1.F1.
- Khemani E, McElhinney DB, Rhein L, et al. Pulmonary artery hypertension in formerly premature infants with bronchopulmonary dysplasia: clinical features and outcomes in the surfactant era. Pediatrics. 2007;120(6):1260-1269. doi: 10.1542/peds.2007-0971.
- Kicinski P, Kesiak M, Nowiczewski M, Gulczynska E. Bronchopulmonary dysplasia in very and extremely low birth weight infants - analysis of selected risk factors. Pol Merkur Lekarski. 2017;42(248):71-75.
- Majnemer A, Riley P, Shevell M, et al. Severe bronchopulmonary dysplasia increases risk for later neurological and motor sequelae in preterm survivors. Dev Med Child Neurol. 2007;42(1):53-60. doi: 10.1111/j.1469-8749.2000.tb00025.x.
- McEvoy CT, Jain L, Schmidt B, et al. Bronchopulmonary dysplasia: NHLBI Workshop on the Primary Prevention of Chronic Lung Diseases. Ann Am Thorac Soc. 2014;11Suppl 3:S146-153. doi: 10.1513/AnnalsATS.201312-424LD.
- Montgomery-Downs HE, Young ME, Ross MA, et al. Sleep-disordered breathing symptoms frequency and growth among prematurely born infants. Sleep Med. 2010;11(3):263-267. doi: 10.1016/j.sleep.2009.06.007.
- Sadeh A. A Brief Screening Questionnaire for Infant Sleep Problems: Validation and Findings for an Internet Sample. Pediatrics. 2004;113(6):e570-e577. doi: 10.1542/peds.113.6.e570.
- Venkata N, Buhary M, Munyard P. Persistent Pulmonary Hypertension of the Newborn (PPHN) – Neonatal Management. Clinical Guideline. Cornwall: Royal Cornwall Hospitals; 2015.
- Lakshminrusimha S, Keszler M. Persistent Pulmonary Hypertension of the Newborn. Neoreviews. 2015;16(12):e680-e692. doi: 10.1542/neo.16-12-e680.
Supplementary files
