电邮这篇文章 
发表评论 Clinico-laboratory efficacy of the drug Viferon® in viral lesions of the gastroin-testinal tract in children
- 作者: Timchenko V.N.1, Subbotina M.D.1, Kaplina T.A.1, Bulina O.V.1, Sukhovetskaya V.F.1, Hakizimana J.1, Shakmaeva M.A.1
-
隶属关系:
- St. Petersburg State Pediatric Medical University
- 期: 卷 9, 编号 3 (2018)
- 页面: 41-48
- 栏目: Articles
- URL: https://journal-vniispk.ru/pediatr/article/view/9131
- DOI: https://doi.org/10.17816/PED9341-48
- ID: 9131
如何引用文章
全文:
详细
In recent years, viral lesions of the gastrointestinal tract take the leading place in the etiological structure of acute intestinal infections. The study of the clinical course and treatment of viral diarrhea in children is an urgent task in modern conditions. We analyzed the disease of 2568 children aged 1 month to 17 years who were hospitalized in a Hospital No 3 in St. Petersburg in the period of 2016-2017. All patients underwent a standard laboratory examination. The etiological interpretation was carried out with the help of polymerase chain reaction, bacteriological and serological methods of investigation. Of the 2568 children in 1502 (58.5%) patients, the diagnosis was confirmed. The share of bacterial diarrhea was 31.8%, viral lesions of the gastrointestinal tract – 68.2%. Among the decoded viral lesions of the gastrointestinal tract, the share of rotavirus infection was 52.8%, norovirus infection – 24.8%, mixed infection – 19.6%. A high proportion of viral lesions of the gastrointestinal tract was established in children under 3 years of age (71.7%). The main reason for hospitalization of children under 5 years of age is rotavirus infection, from 5 to 12 years – norovirus infection. Almost always (87.6%), viral diarrhea proceeded in a moderate form. In infants, mixed viral infection was recorded in severe form. The use of Viferon® in the form of rectal suppositories to supplement the basic therapy of viral intestinal infections significantly reduces the duration of intoxication syndrome, fever, diarrhea, catarrhal syndrome, the duration elimination of viruses, and the length of stay in the hospital.
作者简介
Vladimir Timchenko
St. Petersburg State Pediatric Medical University
编辑信件的主要联系方式.
Email: timchenko220853@yandex.ru
MD, PhD, Dr Med Sci, Professor, Head, Department of Infectious Diseases in Children named after. prof. M.G. Danilevich
俄罗斯联邦, Saint PetersburgMaria Subbotina
St. Petersburg State Pediatric Medical University
Email: m.03@bk.ru
MD, PhD, Associate Professor, Department of Infectious Diseases in Children named after. prof. M.G. Danilevich
俄罗斯联邦, Saint PetersburgTatyana Kaplina
St. Petersburg State Pediatric Medical University
Email: detinfection@mail.ru
MD, PhD, Associate Professor, Department of Infectious Diseases in Children named after. prof. M.G. Danilevich
俄罗斯联邦, Saint PetersburgOksana Bulina
St. Petersburg State Pediatric Medical University
Email: detinfection@mail.ru
MD, PhD, Associate Professor, Department of Rehabilitation of the AF and DPO
俄罗斯联邦, Saint Petersburg, RussiaVera Sukhovetskaya
St. Petersburg State Pediatric Medical University
Email: detinfection@mail.ru
MD, PhD, Associate Professor, Department of Infectious Diseases in Children named after. prof. M.G. Danilevich
俄罗斯联邦, Saint PetersburgJean-Claude Hakizimana
St. Petersburg State Pediatric Medical University
Email: detinfection@mail.ru
MD, PhD, Associate Professor, Department of Infectious Diseases in Children named after. prof. M.G. Danilevich
俄罗斯联邦, Saint PetersburgMaria Shakmaeva
St. Petersburg State Pediatric Medical University
Email: detinfection@mail.ru
student of the 6th course
俄罗斯联邦, Saint Petersburg参考
- Горелов А.В., Феклисова Л.В., Плоскирева А.А., и др. Комплексная терапия вирусной диареи у детей - первые результаты открытого сравнительного рандомизированного клинического исследования препаратов интерферона // Педиатрическая фармакология. - 2011. - Т. 8. - № 4. - С. 106-111. [Gorelov AV, Feklisova LV, Ploskireva AA, et al. Combined therapy of viral diarrhea in children: first results of an open comparative randomized clinical trial of interferon efficiency. Pediatric pharmacology. 2011;8(4):106-111. (In Russ.)]
- Григорович М.С. Исходы острых кишечных инфекций у детей, факторы их определяющие, и оптимизация путей реабилитации: Автореф. дис. … д-ра мед. наук. - М.: ФБУН «Центральный научно-исследовательский институт эпидемиологии», 2011. [Grigorovich MS. Outcomes of acute intestinal infections in children, determining factors, optimization of rehabilitation routes. [dissertation] Moscow: FBUN “Tsentral’nyy nauchno-issledovatel’skiy institut epidemiologii”; 2011. (In Russ.)]
- Инфекционные болезни у детей: учебник для педиатрических факультетов медицинских вузов / Под ред. В.Н. Тимченко. - СПб.: СпецЛит, 2012. [VN Timchenko, editor. Infectious diseases in children: textbook for pediatric faculties of medical schools. Saint Petersburg: SpetsLit; 2012. (In Russ.)]
- Лукьянова А.М., Бехтерева М.К., Птичникова Н.Н. Клинико-эпидемиологическая характеристика вирусных диарей у детей // Журнал инфектологии. - 2014. - Т. 6. - № 1. - С. 60-66. [Lukyanova АM, Bekhtereva MK, Ptichnikova NN. Clinical and epidemiological characteristic viral diarrhea in children. Zhurnal infektologii. 2014;6(1):60-66. (In Russ.)]
- Мазанкова Л.Н., Чеботарева Т.А., Майкова И.Д. Современные подходы к совершенствованию иммунобиологической терапии при вирусных диареях у детей // Педиатрическая фармакология. - 2008. - Т. 5. - № 5. - С. 116-120. [Mazankova LN, Chebotareva TA, Maykova ID. Up-to-date approaches to improving immunobiological therapy of viral diarrhea of children. Pediatric pharmacology. 2008;5(5):116-120. (In Russ.)]
- Малов В.А., Горобченко Е.А., Городнова Е.А. Вирусные гастроэнтериты // Лечащий врач. - 2002. - № 11. - С. 54-58. [Malov VА, Gorobchenko AN, Gorodnova EA. Viral gastroenteritis. Practitioner. 2002;(11):54-58. (In Russ.)
- Михайлова Е.В., Данилов А.Н., Левин Д.Ю. Клинико-лабораторная характеристика вирусных диарей у детей и противовирусная терапия // Детские инфекции. - 2012. - Т. 11. - № S. - С. 44-48. [Mikhaylova EV, Danilov AN, Levin DY. Clinical and Laboratory Characteristics of Viral Diarrhea in Children and Antiviral Therapy. Detskie infektsii. 2012;11(S):44-48. (In Russ.)]
- Нестеров И.В. Препараты интерферона альфа в клинической практике // Российский аллергологический журнал. - 2010. - № 2. - С. 43-52. [Nesterov IV. Interferon-α in clinical practice. Rossiiskii allergologicheskii zhurnal. 2010;(2):43-52. (In Russ.)]
- Острые кишечные инфекции в практике педиатра и семейного врача: руководство для врачей всех специальностей / Под ред. В.Н. Тимченко, В.В. Левановича. - СПб.: Издательство Н-Л, 2011. [VN Timchenko, VV Levanovich, editors. Acute intestinal infections in the practice of a pediatrician and family doctor: manual for physicians of all specialties. Saint Petersburg: Izdatelstvo N-L; 2011. (In Russ.)]
- Раздьяконова И.В. Клинико-иммунологическая характеристика калицивирусной инфекции у детей и тактика терапии: Автореф. дис. … канд. мед. наук. - СПб, 2007. [Razdyakonova IV. Clinical and immunological characteristics of calicivirus infection in children and tactics of therapy. [dissertation] Saint Petersburg; 2002. (In Russ.)]
- Чернова Т.М., Субботина М.Д., Рубцова С.К. Эффективность препарата кагоцел при вирусных поражениях желудочно-кишечного тракта у детей // Медицинский совет. - 2015. - № 1. - С. 40-44. [Chernova TM, Subbotina MD, Rubtsova SK. Effect of Kagocel on viral lesions of the gastrointestinal tract in children. Meditsinskiy sovet. 2015;(1):40-44. (In Russ.)]
- Тимченко В.Н., Павлова Е.Б., Субботина М.Д. Особенности течения и лечения ротавирусной инфекции у детей // Лечащий врач. - 2011. - № 8. - С. 107-108. [Timchenko VN, Pavlova EB, Subbotina MD. Features of the clinic and treatment of rotavirus infection in children. Practitioner. 2011;(8):107-108. (In Russ.)]
- Шестакова И.В. Норовирусная инфекция // Consilium Medicum. - 2013. - Т. 15. - № 12. - С. 34-37. [Shestakova IV. Norovirus infection. Consilium Medicum. 2013;15(12):34-37. (In Russ.)]
- Lanata CF, Fischer-Walker CL, Olascoaga AC, et al. Global causes of diarrheal disease mortality in children №5 years of age: a systematic review. PLoS One. 2013;8(9):e72788. doi: 10.1371/journal.pone.0072788.
- Dey RS, Ghosh S, Chawla-Sarkar M, et al. Circulation of a novel pattern of infections by enteric adenovirus serotype 41 among children below 5 years of age in Kolkata, India. J Clin Microbiol. 2011;49(2):500-505. doi: 10.1128/JCM.01834-10.
- Matsumoto T, Wangchuk S, Tshering K, et al. Complete Genome Sequences of Two Astrovirus MLB1 Strains from Bhutanese Children with Diarrhea. Genome Announc. 2013;1(4). doi: 10.1128/genomeA.00485-13.
- Wikswo ME, Desai R, Edwards KM, et al. Clinical profile of children with norovirus disease in rotavirus vaccine era. Emerg Infect Dis. 2013;19(10):1691-1693. doi: 10.3201/eid1910.130448.
- Matsushima Y, Shimizu H, Kano A, et al. Genome sequence of a novel virus of the species human adenovirus d associated with acute gastroenteritis. Genome Announc. 2013;1(1). doi: 10.1128/genomeA.00068-12.
补充文件
