Correction of pain-related and affective behavior by combination of fluoxetine and buspirone in prenatally stressed rats
- 作者: Butkevich I.P.1, Mikhaylenko V.A.1, Shimarayeva T.N.2, Kochubeev A.V.2
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隶属关系:
- I.P. Pavlov Institute of Physiology, Russian Academy of Sciences
- St. Petersburg State Pediatric Medical University
- 期: 卷 9, 编号 3 (2018)
- 页面: 57-63
- 栏目: Articles
- URL: https://journal-vniispk.ru/pediatr/article/view/9133
- DOI: https://doi.org/10.17816/PED9357-63
- ID: 9133
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The inhibitor of serotonin (5-HT) reuptake fluoxetine does not cause any improvement in every patient suffering from depression; moreover, fluoxetine during pregnancy disrupts the normal development of the fetus. Clinical observations in adult patients suggest that treatment of depression with a combination of fluoxetine and 5-HT1A receptor agonists has a higher therapeutic effect than the effect of a single fluoxetine. In the present study, the effect of chronic management of the combination of fluoxetine and a 5-HT1A receptor agonist anxiolytic buspirone was examined in order to correct the adverse effects of prenatal stress on pain and affective behavior in the female offspring during the prepubertal period of development. It was found that the immobilization stress of rat dams in the last third of pregnancy (the stress of rat dams during pregnancy is used as a model of human depression) caused in the offspring the increased functional activity of the pain system, an increase in the level of depressive-like behavior. Chronic administration to pregnant dams of fluoxetine, buspirone, or their combination has improved the characteristics under study in the female offspring. The results indicate that the chronic administration of a combination of fluoxetine and buspirone during the gestation of rat dams neutralized the negative effect of prenatal stress in female offspring. More effective action of the combination of the drugs compared with the action of fluoxetine was revealed in the pain sensitivity to thermal stimulus and in the first acute phase of pain behavior in the formalin test. Undesirable deviations in the investigated types of behavior in female rats subjected to pharmacological effects of each of the drugs during the prenatal period were not revealed.
作者简介
Irina Butkevich
I.P. Pavlov Institute of Physiology, Russian Academy of Sciences
编辑信件的主要联系方式.
Email: irinabutkevich@yandex.ru
Dr. Sci., Project Leader, Lab. of Ontogeny of Nervous System
俄罗斯联邦, Saint PetersburgViktor Mikhaylenko
I.P. Pavlov Institute of Physiology, Russian Academy of Sciences
Email: viktormikhailenko@yandex.ru
PhD, Senior Researcher. Lab. of Ontogeny of Nervous System
俄罗斯联邦, Saint PetersburgTatyana Shimarayeva
St. Petersburg State Pediatric Medical University
Email: 3706381@mail.ru
PhD, Associate Professor, Department of Normal Physiology
俄罗斯联邦, Saint PetersburgAndrei Kochubeev
St. Petersburg State Pediatric Medical University
Email: AndreyKo4@mail.ru
PhD, Associate Professor, Department of Normal Physiology
俄罗斯联邦, Saint Petersburg参考
- Albert PR, Francois BL. Modifying 5-HT1A Receptor Gene Expression as a New Target for Antidepressant Therapy. Front Neurosci. 2010;4:35. doi: 10.3389/fnins.2010.00035.
- Brummelte S, Mc Glanaghy E, Bonnin A, Oberlander TF. Developmental changes in serotonin signaling: Implications for early brain function, behavior and adaptation. Neuroscience. 2017;342:212-231. doi: 10.1016/j.neuroscience.2016.02.037.
- Butkevich IP, Mikhailenko VA, Vershinina EA, et al. Buspirone before prenatal stress protects against adverse effects of stress on emotional and inflammatory pain-related behaviors in infant rats: age and sex differences. Brain Res. 2011;1419:76-84. doi: 10.1016/j.brainres.2011.08.068.
- Butkevich I, Mikhailenko V, Vershinina E, et al. Maternal buspirone protects against the adverse effects of in utero stress on emotional and pain-related behaviors in offspring. Physiol Behav. 2011;102(2): 137-142. doi: 10.1016/j.physbeh.2010.10.023.
- Colpaert FC. 5-HT(1A) receptor activation: new molecular and neuroadaptive mechanisms of pain relief. Curr Opin Investig Drugs. 2006;7(1):40-47.
- Eyre H, Siddarth P, Cyr N, et al. Comparing the Immune-Genomic Effects of Vilazodone and Paroxetine in Late-Life Depression: A Pilot Study. Pharmacopsychiatry. 2017;50(6):256-263. doi: 10.1055/s-0043-107033.
- Glover ME, Clinton SM. Of rodents and humans: A comparative review of the neurobehavioral effects of early life SSRI exposure in preclinical and clinical research. Int J Dev Neurosci. 2016;51:50-72. doi: 10.1016/j.ijdevneu.2016.04.008.
- Mahar I, Bambico FR, Mechawar N, Nobrega JN. Stress, serotonin, and hippocampal neurogenesis in relation to depression and antidepressant effects. Neurosci Biobehav Rev. 2014;38:173-192. doi: 10.1016/j.neubiorev.2013.11.009.
- Muzerelle A, Scotto-Lomassese S, Bernard JF, et al. Conditional anterograde tracing reveals distinct targeting of individual serotonin cell groups (B5-B9) to the forebrain and brainstem. Brain Struct Funct. 2016;221(1): 535-561. doi: 10.1007/s00429-014-0924-4.
- Pawluski JL, Rayen I, Niessen NA, et al. Developmental fluoxetine exposure differentially alters central and peripheral measures of the HPA system in adolescent male and female offspring. Neuroscience. 2012;220:131-141. doi: 10.1016/j.neuroscience.2012.06.034.
- Richardson-Jones JW, Craige CP, Guiard BP, et al. 5-HT1A autoreceptor levels determine vulnerability to stress and response to antidepressants. Neuron. 2010;65(1):40-52. doi: 10.1016/j.neuron.2009.12.003.
- Van den Hove DL, Lauder JM, Scheepens A, et al. Prenatal stress in the rat alters 5-HT1A receptor binding in the ventral hippocampus. Brain Res. 2006;1090(1): 29-34. doi: 10.1016/j.brainres.2006.03.057.
- Wang SM, Han C, Lee SJ, et al. Vilazodone for the Treatment of Depression: An Update. Chonnam Med J. 2016;52(2):91-100. doi: 10.4068/cmj.2016.52.2.91.
- Weinstock M. Prenatal stressors in rodents: Effects on behavior. Neurobiol Stress. 2017;6:3-13. doi: 10.1016/j.ynstr.2016.08.004.
- Wong K, Phelan R, Kalso E, et al. Antidepressant drugs for prevention of acute and chronic postsurgical pain: early evidence and recommended future directions. Anesthesiology. 2014;121(3):591-608. doi: 10.1097/ALN.0000000000000307.
- Yohn CN, Gergues MM, Samuels BA. The role of 5-HT receptors in depression. Mol Brain. 2017;10(1):28. doi: 10.1186/s13041-017-0306-y.
- Zhuo M. Descending facilitation. Mol Pain. 2017;13:1744806917699212. doi: 10.1177/ 1744806917699212.
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