Evaluating the effectiveness of resuscitation with extracorporeal membrane oxygenation in a model of acute hypoxic cardiac arrest in pigs (experimental study)

Gennadiy Grigoryevich Khubulava; Хубулава Геннадий Григорьевич; Aleksey Borisovich Naumov; Наумов Алексей Борисович; Sergey Pavlovich Marchenko; Марченко Сергей Павлович; Vitaliy Vladimirovich Suvorov; Суворов Виталий Владимирович; Igor Igorevich Averkin; Аверкин Игорь Игоревич; Oksana Vladimirovna Nevmerzhitskaya; Невмержицкая Оксана Владимировна; Vladimir Vladimirovich Zaytsev; Зайцев Владимир Владимирович; Anastasiya Alekseyevna Seliverstova; Селиверстова Анастасия Алексеевна; Vadim Vladimirovich Andreyev; Андреев Вадим Владимирович; Sergey Vasilyevich Vlasenko; Власенко Сергей Васильевич

doi:10.17816/PED5420-26

Evaluating the effectiveness of resuscitation with extracorporeal membrane oxygenation in a model of acute hypoxic cardiac arrest in pigs (experimental study)

Authors: Khubulava G.G.¹, Naumov A.B.¹, Marchenko S.P.¹, Suvorov V.V.¹, Averkin I.I.¹, Nevmerzhitskaya O.V.¹, Zaytsev V.V.¹, Seliverstova A.A.¹, Andreyev V.V.¹, Vlasenko S.V.²
Affiliations:
1. Saint Petersburg State Pediatric Medical University
2. City hospital N 40
Issue: Vol 5, No 4 (2014)
Pages: 20-26
Section: Articles
URL: https://journal-vniispk.ru/pediatr/article/view/1160
DOI: https://doi.org/10.17816/PED5420-26
ID: 1160

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Abstract

Cardiopulmonary resuscitation (CPR) with closed-chest cardiac massage was developed to maintain circulation and ventilation until life-threatening problems could be corrected or reversed. Studies on the effect of CPR have shown that about 80-95 % cases of resuscitation are fatal or severe neurological consequences and survival to discharge after CPR ranged from 6 to 22 % [2, 4, 8, 11]. Furthermore, the chances of survival decline rapidly if the resuscitation period more than 10 minute. At the same time, we know that successful neurologic outcomes are inversely associated with the time of brain hypoperfusion. Because of the low survival rate after prolonged CPR, more aggressive methods have been suggested to increase success. With the advancement of techniques, extracorporeal mechanical support has been applied in conjunction with CPR, with variable results [5, 12]. To assess the efficacy of resuscitation with extracorporeal membrane oxygenation was modeled the acute hypoxic cardiac arrest in pigs. Results of the study in the two groups demonstrate efficient switching method supporting circulatory support (ECMO) in the minutes of CPR. In the provision of an extended set of measures of cardiopulmonary resuscitation in the modeling of hypoxic cardiac arrest in animals in the group with ECMO received great survival to the end of the experiment, less expressed manifestations of acute heart failure. Intergroup comparison given the prerequisites for the development of protocols with the use of ECMO CPR, which would reduce the number of complications and death in patients undergoing cardiac surgery.

Keywords

cardiopulmonary resuscitation, resuscitation with extracorporeal membrane oxygenation, ECMO after cardiac surgery, cerebral perfusion, cerebral protection

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References

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Evaluating the effectiveness of resuscitation with extracorporeal membrane oxygenation in a model of acute hypoxic cardiac arrest in pigs (experimental study)

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