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发表评论 Importance of activity of autophagy, apoptosis and intracellular protein degradation for early detection of malnutrition in patients with chronic kidney disease of 5th stage, receiving of hemodialysis: the results of case-control study
- 作者: Prometnaya G.A.1, Batushin M.M.2, Bondarenko N.B.2
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隶属关系:
- Rostov Regional Children Clinical Hospital
- Rostov State Medical University of the Ministry of Healthcare of the Russian Federation
- 期: 卷 9, 编号 6 (2018)
- 页面: 29-36
- 栏目: Articles
- URL: https://journal-vniispk.ru/pediatr/article/view/11221
- DOI: https://doi.org/10.17816/PED9629-36
- ID: 11221
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详细
Malnutrition significant affects the flowing and prognosis of chronic kidney disease (CKD) of 5th stage. It’s early detection with assistance is actual problem.
Purpose. Detect of more sensitive markers for diagnostic assessment of malnutrition and elucidate of availability of autophagy, apoptosis and intracellular protein degradation’ markers for the purpose.
Methods. It was made prospective case-control study. CKD of 5th stage’ patients with hemodialysis were included. Objective, laboratory study (n = 106) and detection of Beclin-1, 20S-proteasoma and Bcl-2’ levels (n = 80) prepared. Last three of them indicated of autophagy, intracellular protein degradation and apoptosis activity appropriately. We had two groups: with malnutrition (n = 93/71) and without it (n = 93/71).
Results. Variability of malnutrition’ quantity, depending on index for verification of it was detected: for index “lymphocytes < 1 800” – 71,1% (59 of 83 investigated patients), “transferrin saturation < 20” – 34% (36 of 106), “serum albumin < 35 g/l” – 1,9% (2), “body mass index < 18,5” – 0,9% (1), “body mass deficit” – 5,7% (6). High level of 20S-proteasome (46,2-72,5 ng/ml) increased of malnutrition chance (OR = 4,88 [95% CI = 1,09–21,84]). Somatic protein pool insufficiency was more frequently, than visceral pool is in malnutrition group: 25,8% (24 of 93) и 2,2% (2 of 93; р < 0,05).
Objective. Biomarkers can find malnutrition earlier than anthropometric indexes, and high level of 20S-proteasome can be early independent predictor of malnutrition.
作者简介
Galina Prometnaya
Rostov Regional Children Clinical Hospital
编辑信件的主要联系方式.
Email: galusik.ru@gmail.com
Nephrologist, Consultation-and- diagnostical Outpatient medical center
俄罗斯联邦, Rostov-on-DonMikhail Batushin
Rostov State Medical University of the Ministry of Healthcare of the Russian Federation
Email: batjushin-m@rambler.ru
MD, PhD, Dr Med Sci, Professor, Department of Internal Diseases No 2
俄罗斯联邦, Rostov-on-DonNikolay Bondarenko
Rostov State Medical University of the Ministry of Healthcare of the Russian Federation
Email: n.bondarenko61@gmail.com
Postgraduate Student, Department of Internal Diseases No 2
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