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发表评论 Сomparative analysis of acridineacetate-containing compounds’ radio-sensitizing effect during malignant tumor experimental radiotherapy in a metastatic colorectal cancer model in balb/c mice
- 作者: Trashkov A.P.1,2,3, Muzhikyan A.A.1,2, Tsygan N.V.1,2, Ryabtsev A.V.2, Rybakova A.V.1,2, Kvanchiani V.V.2, Kravtsova A.A.4, Vasiliev A.G.4
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隶属关系:
- National Research Centre “Kurchatov Institute”
- B.P. Konstantinov Petersburg Nuclear Physics Institute of the National Research Centre “Kurchatov Institute”
- Peter the Great St. Petersburg Polytechnic University
- St. Petersburg State Pediatric Medical University of the Ministry of Healthcare of the Russian Federation
- 期: 卷 11, 编号 6 (2020)
- 页面: 45-53
- 栏目: Original studies
- URL: https://journal-vniispk.ru/pediatr/article/view/64890
- DOI: https://doi.org/10.17816/PED11645-53
- ID: 64890
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详细
Radio-sensitizing compounds are used to increase radiotherapy effectivity and reduce negative pathologic systemic effects of radiation. These radio-sensitizers selectively pile-up in tumor tissue and enhance necrobiotic processes caused by irradiation. Unfortunately, broad introduction of radio-sensitizers into clinical practice is hampered by their low effectivity and substantial negative side effects. This what determines radio-sensitizers effectivity studies high actuality in a colorectal cancer mice model. The study involved 156 male BALB/c mice who had been transplanted with colorectal cancer. After the transplantation they were injected with acridineacetate – containing compounds Cyclopherone and Procitol. A comparative assessment was undertaken of tumor growth dynamics and metastatic rate. A combination of gamma-irradiation with radio-sensitizing compounds produces a more substantial therapeutic effect according to all parameters of the experimental colorectal cancer growth and development than the isolated effect of radiotherapy or antitumor drugs. A considerable slowing down of tumor growth on the 14th and 28th day of the study was revealed as well as a reliable inhibition of lymphogenous and hematogenous metastatic spread of neoplasma during the entire study and a statistically valid increase of lifespan of the experimental animals. The radiosensitizing effect of Procitol in combination with radiotherapy turned out to be more substantial than that of Cyclopherone.
作者简介
Alexander Trashkov
National Research Centre “Kurchatov Institute”; B.P. Konstantinov Petersburg Nuclear Physics Institute of the National Research Centre “Kurchatov Institute”; Peter the Great St. Petersburg Polytechnic University
编辑信件的主要联系方式.
Email: trashkov_ap@pnpi.nrcki.ru
PhD, MD, Head of Preclinincal and Clinical Studies Center, B.P. Konstantinov Petersburg Nuclear Physics Institute of the National Research Centre “Kurchatov Institute”; Head of Preclinincal and Clinical Studies Center, B.P. Konstantinov Petersburg Nuclear Physics Institute of the National Research Centre “Kurchatov Institute”; Assoc. Professor, St. Petersburg Polytechnical University
俄罗斯联邦, Moscow; Saint Petersburg; Saint PetersburgArman Muzhikyan
National Research Centre “Kurchatov Institute”; B.P. Konstantinov Petersburg Nuclear Physics Institute of the National Research Centre “Kurchatov Institute”
Email: vetdiagnostics.spb@gmail.com
PhD, Leading Researcher in Preclinincal and Clinical Studies Center, B.P. Konstantinov Petersburg Nuclear Physics Institute of the National Research Centre “Kurchatov Institute”; Leading Researcher in Preclinincal and Clinical Studies Center, B.P. Konstantinov Petersburg Nuclear Physics Institute of the National Research Centre “Kurchatov Institute”
俄罗斯联邦, Moscow; Saint PetersburgNikolay Tsygan
National Research Centre “Kurchatov Institute”; B.P. Konstantinov Petersburg Nuclear Physics Institute of the National Research Centre “Kurchatov Institute”
Email: tsygan_nv@pnpi.nrcki.ru
PhD, MD, Dr. Sci. (Med.), Leading Researcher in Preclinincal and Clinical Studies Center, B.P. Konstantinov Petersburg Nuclear Physics Institute of the National Research Centre “Kurchatov Institute”; Leading Researcher in Preclinincal and Clinical Studies Center, B.P. Konstantinov Petersburg Nuclear Physics Institute of the National Research Centre “Kurchatov Institute”
俄罗斯联邦, Moscow; Saint PetersburgAlexander Ryabtsev
B.P. Konstantinov Petersburg Nuclear Physics Institute of the National Research Centre “Kurchatov Institute”
Email: ryabtsev26@gmail.com
Junior Researcher in Preclinincal and Clinical Studies Center
俄罗斯联邦, Saint PetersburgAnna Rybakova
National Research Centre “Kurchatov Institute”; B.P. Konstantinov Petersburg Nuclear Physics Institute of the National Research Centre “Kurchatov Institute”
Email: rybakova_av@pnpi.nrcki.ru
PhD, Senior Researcher in Preclinincal and Clinical Studies Center, B.P. Konstantinov Petersburg Nuclear Physics Institute of the National Research Centre “Kurchatov Institute”; Senior Researcher in Preclinincal and Clinical Studies Center, B.P. Konstantinov Petersburg Nuclear Physics Institute of the National Research Centre “Kurchatov Institute”
俄罗斯联邦, Moscow; Saint PetersburgVarvara Kvanchiani
B.P. Konstantinov Petersburg Nuclear Physics Institute of the National Research Centre “Kurchatov Institute”
Email: kvanchiani_vv@pnpi.nrcki.ru
PhD, Senior Researcher in Preclinincal and Clinical Studies Center
俄罗斯联邦, Saint PetersburgAleftina Kravtsova
St. Petersburg State Pediatric Medical University of the Ministry of Healthcare of the Russian Federation
Email: aleftinakravcova@mail.ru
PhD, Associated Professor, Department Pathophysiology and Immunopathology
俄罗斯联邦, Saint PetersburgAndrei Vasiliev
St. Petersburg State Pediatric Medical University of the Ministry of Healthcare of the Russian Federation
Email: avas7@mail.ru
MD, PhD, Dr. Sci. (Med.), Head of Department Pathophysiology and Immunopathology
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