Levobupivacaine for regional blockades in orthopedics and traumatology in children: recent evidence and future directions
- Authors: Ulrikh G.E.1, Zabolotskii D.V.1, Aleksandrovich Y.S.1, Koryachkin V.A.1, Nezabudkin S.N.1, Ulrikh D.G.1
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Affiliations:
- Saint Petersburg State Pediatric Medical University
- Issue: Vol 6, No 4 (2018)
- Pages: 77-83
- Section: Review
- URL: https://journal-vniispk.ru/turner/article/view/10343
- DOI: https://doi.org/10.17816/PTORS6477-83
- ID: 10343
Cite item
Abstract
Levobupivacaine is an amide anesthetic, levorotatory isomer of bupivacaine. This literature review aimed to present the possibilities of levobupivacaine in the implementation of blockades for anesthesia in traumatology and orthopedics in children. Levobupivacaine is widely used for analgesia for orthopedic interventions in adults and has become an alternative to the less safe bupivacaine. The actions of levobupivacaine, bupivacaine, and ropivacaine in the implementation of neuroaxial and peripheral blockades, and the infiltration of postoperative wounds in children were compared in the present study. Levobupivacaine has been confirmed to be safe compared with bupivacaine in pediatric patients. Studies in children of different ages comparing levobupivacaine and ropivacaine, used for anesthesia in traumatology and orthopedics, indicate the same or greater analgesic potential of levobupivacaine, with a similar level of safety. Compared with ropivacaine, levobupivacaine provides comparable pain relief at lower concentrations. The presented clinical data of levobupivacaine use in children allow the expansion of the indications for anesthesia in orthopedics and traumatology. Clinical research should be continued to compare the effectiveness of different concentrations of levobupivacaine and ropivacaine in larger groups of pediatric patients. Relevant papers were obtained by searching PubMed and Scopus databases.
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##article.viewOnOriginalSite##About the authors
Gleb E. Ulrikh
Saint Petersburg State Pediatric Medical University
Author for correspondence.
Email: ostrovgl@rambler.ru
ORCID iD: 0000-0001-7491-4153
MD, PhD, Professor of the Department of Anesthesiology and Pediatric Intensive Care
Russian Federation, 2, Litovskay street, Saint-Peterburg, 194100Dmitri V. Zabolotskii
Saint Petersburg State Pediatric Medical University
Email: ostrovgl@rambler.ru
ORCID iD: 0000-0002-6127-0798
MD, PhD, Сhief of the Department of Anesthesiology and Pediatric Intensive Care
Russian Federation, 2, Litovskay street, Saint-Peterburg, 194100Yuri S. Aleksandrovich
Saint Petersburg State Pediatric Medical University
Email: ostrovgl@rambler.ru
ORCID iD: 0000-0002-2131-4813
MD, PhD, Сhief of the Department of Anesthesiology and Pediatric Intensive Care
Russian Federation, 2, Litovskay street, Saint-Peterburg, 194100Viktor A. Koryachkin
Saint Petersburg State Pediatric Medical University
Email: ostrovgl@rambler.ru
ORCID iD: 0000-0002-3400-8989
MD, PhD, Professor of the Department of Anesthesiology and Pediatric Intensive Care
Russian Federation, 2, Litovskay street, Saint-Peterburg, 194100Sevir N. Nezabudkin
Saint Petersburg State Pediatric Medical University
Email: ostrovgl@rambler.ru
ORCID iD: 0000-0002-4341-4380
MD, PhD, Professor of the Department of Anesthesiology and Pediatric Intensive Care
Russian Federation, 2, Litovskay street, Saint-Peterburg, 194100Daria G. Ulrikh
Saint Petersburg State Pediatric Medical University
Email: ostrovgl@rambler.ru
ORCID iD: 0000-0002-1346-933X
Student of Pediatric Faculty
Russian Federation, 2, Litovskay street, Saint-Peterburg, 194100References
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