Email this article Local recurrences after radical cystectomy in bladder cancer patients
- Authors: Komyakov B.K.1,2, Saad A.E.1, Fadeev V.A.1,2, Al-Attar T.H.1,2, Sergeev A.V.1,2
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Affiliations:
- North-Western State Medical University named after I.I. Mechnikov
- Multidisciplinary City Hospital No. 2
- Issue: Vol 12, No 4 (2022)
- Pages: 269-276
- Section: Original articles
- URL: https://journal-vniispk.ru/uroved/article/view/134229
- DOI: https://doi.org/10.17816/uroved112087
- ID: 134229
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Abstract
BACKGROUND: Radical cystectomy is the standard treatment for patients with muscle-invasive bladder cancer and superficial neoplasms in cases of resistance to intravesical immunochemotherapy.
AIM: To establish the frequency of local pelvic recurrence in patients with bladder cancer after radical cystectomy.
MATERIALS AND METHODS: From 1997 to 2022 radical cystectomy was performed in 407 patients with bladder cancer: 344 (84.5%) men and 63 (15.5%) women. Orthotopic urinary diversion methods were performed in 302 (74.2%) patients, including gastrocystoplasty — 24 (5.9%), ileocystoplasty — 253 (63.8%) and sigmocystoplasty — 25 (6.1%) patients. Continent skin diversion of urine was performed in 13 (3.2%) patients, ureter transplantation into the sigmoid colon — in 42 (10.3%) patients, and ureterocutaneostomy — in 50 (12.3%) patients.
RESULTS: Local recurrence in the pelvis after radical cystectomy was observed in 33 (8.1%) patients: 27 (81.8%) men and 6 (18.2%) women. The average age of men with relapses was 58.7 ± 11.7 years (from 43 to 73 years), women — 50.0 ± 7.8 years (from 24 to 65 years). Simultaneous metastatic lesions of internal organs were detected in 6 (18.2%) patients. Local pelvic recurrence after radical cystectomy occurred more often in lymphopositive patients with extravesical spread of the primary low-grade tumor. The median time from radical cystectomy to detection of pelvic recurrence was 7.0 months, from the moment of detection of pelvic recurrence to the death of the patient — 4.5 months.
CONCLUSIONS: The frequency of local pelvic recurrence of bladder cancer after radical cystectomy is 8.1%. The survival rate of patients with local pelvic recurrence is extremely low.
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##article.viewOnOriginalSite##About the authors
Boris K. Komyakov
North-Western State Medical University named after I.I. Mechnikov; Multidisciplinary City Hospital No. 2
Email: komyakovbk@mail.ru
ORCID iD: 0000-0002-8606-9791
SPIN-code: 7864-9123
Dr. Sci. (Med.), Professor; Head of the Department of Urology; Head of the Urological Unit
Russian Federation, Saint Petersburg; Saint PetersburgAnton E. Saad
North-Western State Medical University named after I.I. Mechnikov
Email: dr.a.e.saad@gmail.com
Postgraduate Student of the Department of Urology
Russian Federation, Saint PetersburgVladimir A. Fadeev
North-Western State Medical University named after I.I. Mechnikov; Multidisciplinary City Hospital No. 2
Email: fad_ur_75@mail.ru
SPIN-code: 6731-2605
Dr. Sci. (Med.); Professor of the Department of Urology; Urologist, Urological Unit
Russian Federation, Saint Petersburg; Saint PetersburgTalat H. Al-Attar
North-Western State Medical University named after I.I. Mechnikov; Multidisciplinary City Hospital No. 2
Email: dr-talat@mail.ru
ORCID iD: 0000-0002-2080-5637
SPIN-code: 9550-7507
Dr. Sci. (Med.); Professor of the Department of Urology; Urologist, Urological Unit
Russian Federation, Saint Petersburg; Saint PetersburgAleksey V. Sergeev
North-Western State Medical University named after I.I. Mechnikov; Multidisciplinary City Hospital No. 2
Author for correspondence.
Email: urolsergeev@gmail.com
ORCID iD: 0000-0002-0324-4911
SPIN-code: 3108-4781
Dr. Sci. (Med.); Professor of the Department of Urology; Urologist, Urological Unit
Russian Federation, Saint Petersburg; Saint PetersburgReferences
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