Email this article 
Post a Comment The connection between the clinical picture of myocardial infarction associated with cardiorenal syndrome with NOS3 gene polymorphism and systemic inflammatory response
- Authors: Siverina А.V.1, Skorodumova E.A.1, Kostenko V.A.1, Pivovarova L.P.1, Ariskina O.B.1, Malyshev M.E.1, Skorodumova E.G.1, Rysev A.V.1, Fedorov A.N.1
-
Affiliations:
- Saint Petersburg I.I. Dzhanelidze Research Institute of Emergency Medicine
- Issue: Vol 10, No 4 (2018)
- Pages: 15-22
- Section: Original research
- URL: https://journal-vniispk.ru/vszgmu/article/view/10260
- DOI: https://doi.org/10.17816/mechnikov201810415-22
- ID: 10260
Cite item
Full Text
Abstract
Background. At present close attention is paid to the study of genetic mutations and markers of systemic inflammatory response (SIR) in patients with cardiorenal syndrome.
Aim. To evaluate the effect of NOS3 gene t786c polymorphism and SVR on the clinical course of hospital and long-term periods in patients with myocardial infarction (MI) and acute kidney injury (AKI).
Materials and methods. 108 patients treated for MI were examined. All patients were divided into 2 groups: the first — 56 patients with IM and AKI, the second — 52 patients with IM but without AKI.
Results. In patients with MI and AKI, heterozygote and homozygote by allele С with NOS3 gene polymorphism Т786С, as well as leukocytosis and elevated C-reactive protein (CRP) in the blood were significantly more frequently detected. In the hospital period there was a large percentage of relapses of acute coronary syndrome (ACS), which led to high mortality. In the long-term period recurrent ACS and stent thromboses were also significantly more frequent, as well as high mortality rate.
The conclusion. Patients with IM and AKI revealed high frequency of allele C inheritance with polymorphism t786c gene NOS3, which in combination with the induction of SVR, being manifested by leukocytosis and increase in the content of CRP in the blood, was associated with the severity of the clinical picture, both in hospital and in the long-term periods.
Full Text
##article.viewOnOriginalSite##About the authors
Аnna V. Siverina
Saint Petersburg I.I. Dzhanelidze Research Institute of Emergency Medicine
Author for correspondence.
Email: Gudkovanna_09@mail.ru
ORCID iD: 0000-0002-6831-2153
SPIN-code: 7817-1246
врач кардиолог отдела неотложной кардиологии и ревматологии
Russian Federation, 3, Budapeshtskaya street, Saint-Petersburg, 192242Elena A. Skorodumova
Saint Petersburg I.I. Dzhanelidze Research Institute of Emergency Medicine
Email: elskor@mail.ru
доктор медицинских наук, старший научный сотрудник отдела неотложной кардиологии и ревматологии
Russian Federation, 3, Budapeshtskaya street, Saint-Petersburg, 192242Viktor A. Kostenko
Saint Petersburg I.I. Dzhanelidze Research Institute of Emergency Medicine
Email: vic2012tor@gmail.com
кандидат медицинских наук, руководитель отдела неотложной кардиологии и ревматологии
Russian Federation, 3, Budapeshtskaya street, Saint-Petersburg, 192242Lyudmila P. Pivovarova
Saint Petersburg I.I. Dzhanelidze Research Institute of Emergency Medicine
Email: pivovaroval@yandex.ru
доктор медицинских наук, руководитель отдела лабораторной диагностики
Russian Federation, 3, Budapeshtskaya street, Saint-Petersburg, 192242Olga B. Ariskina
Saint Petersburg I.I. Dzhanelidze Research Institute of Emergency Medicine
Email: olga.ariskina@mail.ru
кандидат биологических наук, научный сотрудник, отдел лабораторной диагностики
Russian Federation, 3, Budapeshtskaya street, Saint-Petersburg, 192242Mikhail E. Malyshev
Saint Petersburg I.I. Dzhanelidze Research Institute of Emergency Medicine
Email: malyshev1972@yandex.ru
доктор биологических наук, заведующий городской лаборатории иммуногенетики и серодиагностики
Russian Federation, 3, Budapeshtskaya street, Saint-Petersburg, 192242Elizaveta G. Skorodumova
Saint Petersburg I.I. Dzhanelidze Research Institute of Emergency Medicine
Email: lisavetta91@mail.ru
ORCID iD: 0000-0002-4961-5570
SPIN-code: 3403-2138
младший научный сотрудник, отдела неотложной кардиологии и ревматологии
Russian Federation, 3, Budapeshtskaya street, Saint-Petersburg, 192242Alexander V. Rysev
Saint Petersburg I.I. Dzhanelidze Research Institute of Emergency Medicine
Email: 79213221618@yandex.ru
кандидат медицинских наук, доцент, заместитель главного врача по терапии
Russian Federation, 3, Budapeshtskaya street, Saint-Petersburg, 192242Artyom N. Fedorov
Saint Petersburg I.I. Dzhanelidze Research Institute of Emergency Medicine
Email: artem_fedorov@inbox.ru
врач кардиолог, отдела неотложной кардиологии и ревматологии
Russian Federation, 3, Budapeshtskaya street, Saint-Petersburg, 192242References
- Erbs S, Gielen S, Linke A, et al. Improvement of peripheral endothelial function by acute vitamin C application: different effects in patients with coronary artery disease, and dilated cardiomyopathy. Am Heart J. 2003;146(2):280-285.
- Yaghoubi AR, Khaki-Khatibi F. T-786C single-nucleotide polymorphism (SNP) of endothelial nitric oxide synthase gene and serum level of vascular endothelial relaxant factor (VERF) in nondiabetic patients with coronary artery disease. African J Biotechnol. 2012;93(11):15945-15949. https://doi.org/10.5897/AJB12.104.
- Nakayama M, Yasue H, Yoshimura M, et al. T-786 ≥ C mutation in the 5’-flanking region of the endothelial nitric oxide synthase gene is associated with coronary spasm. Circulation. 1999;99:2864-2870. https://doi.org/10.1161/01.CIR.99.22.2864.
- Casas JP, Bautista LE, Humphries SE, et al. Endothelial nitric oxide synthase genotype and ischemic heart disease: metaanalysis of 26 studies involving 23028 subjects. Circulation. 2004;109:1359-1365.
- Li J, Wu X, Li X, et al. The Endothelial Nitric Oxide Synthase Gene Is Associated with Coronary Artery Disease: A Meta-Analysis. Cardiology. 2010;116(4):271-278.
- Чеpешнев В.A., Гуcев Е.Ю. Иммунoлoгичеcкие и пaтoфизиoлoгичеcкие мехaнизмы cиcтемнoгo вocпaления // Медицинcкaя иммунoлoгия. – 2012. – Т. 14. – № 1–2. – C. 9–20. [Chereshnev VA, Gusev EYu. Immunological and Pathophysiological mechanisms of Systemic Inflammation. Meditsinskaya Immunologiya. 2012;14(1-2):9-20. (In Russ.)]
- Liaudet L, Rosenblatt-Velin N. Role of innate immunity in cardiac inflammation after myocardial infarction. Front Biosci (Schol Ed). 2013;5:86-104.
- Шевченкo O.П., Cлеcapевa Ю.C., Шевченкo A.O. Poль PAPP-A в paзвитии пoвpеждения aтеpocклеpoтичеcкoй бляшки у бoльных ишемичеcкoй бoлезнью cеpдцa // Poccийcкий кapдиoлoгичеcкий жуpнaл. – 2011. – № 2. – C. 65–71. [Shevchenko OP, Slesareva YS, Shevchenko AO. РАРР-А and atherosclerotic plaque injury in patients with coronary heart disease. Russian Journal of Cardiology. 2011;(2):65-71. (In Russ.)]. https://doi.org/10.15829/1560-4071-2011-2-65-71.
- Cine N, Hatemi AC, Enginel Unaltuna N. Association of polymorphism of the ec NOS gene with myocardial infarction in a subgroup of Turkish MI patients. Clin Genet. 2002;61:66.
- Куба А.А., Никонова Ю.М., Феликсова О.М., и др. Ассоциация генетического полиморфизма гена эндотелиальной синтазы оксида азота с сердечно-сосудистой патологией // Современные проблемы науки и образования. – 2015. – № 3. URL: http://science-education.ru/ru/article/view?id=17352. Ссылка активна на 15.08.2018. [Kuba AA, Nikonova YuM, Feliksova OM, et al. Associaciya geneticheskogo polimorfizma gena endotelial’noj sintazy oksida azota s serdechno-sosudistoj patologiej. Sovremennye problemy nauki i obrazovaniya. 2015;(3). (In Russ.)]
- Клинические практические рекомендации KDIGO по острому почечному повреждению // Нефрология и диализ. – 2014. – Т. 16. – № 4. – С. 1–155. http://www.kidney-international.org. [Klinicheskie prakticheskie rekomendacii KDIGO po ostromu pochechnomu Povrezhdeniyu. Nefrologiya i dializ. 2014;16(4):1-155. (In Russ.)]
- Сиверина А.В., Скородумова Е.А., Костенко В.А., и др. Генетические варианты функционирования ключевых патогенетических механизмов у пациентов с инфарктом миокарда и острым кардиоренальным синдромом // Трансляционная медицина. – 2017. – Т. 4. – № 6. – С. 6–12. [Siverina AV, Skorodumova EA, Kostenko VA, et al. Genetic variants of functioning of the key pathogenetic mechanisms in patients with myocardial infarction and acute cardiorenal syndrome. Translational Medicine. 2017;4(6):6-12. (In Russ.)]. https://doi.org/10.18705/2311-4495-2017-4-6-6-12.
- Ghilardi G, Biondi ML, DeMonti M, et al. Independent risk factor for moderate to severe internal carotid artery stenosis: T786C mutation of endothelial nitric oxide synthase gene. Clin Chem. 2000;48(7):989-993.
- Colombo MG, Paradossi U, Andreassi MG, et al. Endothelial nitric oxide synthase gene polymorphisms and risk of coronary artery disease. Clin Chem. 2003;49(3):389-395.
- Досенко В.Е., Лутай Я.М., Загорий В.Ю., и др. Частота аллельного полиморфизма гена эндотелиальной NO-синтазы у больных с острым коронарным синдромом в украинской популяции // Цитология и генетика. – 2005. – Т. 39. – № 2 – С. 49–54. [Dosenko VE, Lutaj YaM, Zagorij VYu, et al. Chastota allel’nogo polimorfizma gena ehndotelial’noj NO-sintazy u bol’nyh s ostrym koronarnym sindromom v ukrainskoj populyacii. Citologiya i genetika. 2005;39(2):49-54. (In Russ.)]
- Кузин М.И., Шкpoб O.C., Кузин Н.М., и дp. Хиpуpгичеcкие бoлезни: Учебник / Пoд pед. М.И. Кузинa. – 3-е изд., пеpеpaб. и дoп. – М.: Медицинa, 2002. – 784 c. [Kuzin MI, Shkpob OC, Kuzin NM, et al. Hirurgicheckie bolezni: Uchebnik. Ed. by M.I. Kuzina. 3rd ed. Moscow: Medicina; 2002. 784 p. (In Russ.)]
- Bone R.C. Toward an epidemiology and natural history of SIRS (systemic inflammatory response syndrome). JAMA. 1992;268 (24):3452-3455.
- Сайганов С.А., Хурцилава О.Г., Хубулава Г.Г., и др. Влияние первичной коронарной баллонной ангиопластики на систолическую функцию левого желудочка у больных с острой сердечной недостаточностью и инфарктом миокарда с зубцом Q нижней локализации // Вестник хирургии им. И.И. Грекова. – 2010. – Т. 169. – № 1. – С. 33–38. [Sayganov SA, Khurtsilava OG, Khubulava GG, et al. The influence of primary coronary balloon angioplasty on the systolic function of the left ventricle in patients with acute heart failure and myocardium infarction with low Q wave. Vestnik khirurgii im. I.I. Grekova. 2010;169(1):33-38. (In Russ.)]
- Сайганов С.А., Гришкин Ю.Н. Использование селективного ингибитора If-каналов ивабрадина для лечения синусовой тахикардии при острой сердечной недостаточности у больных ишемической болезнью сердца с нижним инфарктом миокарда // Кардиоваскулярная терапия и профилактика. – 2010. – Т. 9. – № 3. – С. 52–56. [Sayganov SA, Grishkin YN. Selective If-channel inhibitor ivabradine in the treatment of sinus tachycardia in coronary heart disease patients with acute heart failure and inferior myocardial infarction. Cardiovascular Therapy and Prevention. 2010;9(3):52-56. (In Russ.)]
- Смирнов А.В., Добронравов В.А., Румянцев А.Ш., Каюков И.Г. Острое повреждение почек. – M.: Медицинское информационное агентство, 2015. – С. 228–238. [Smirnov AV, Dobronravov VA, Rumyantsev ASh, Kayukov IG. Acute kidney injury. Moscow: Medical information Agency; 2015. P. 228-238. (In Russ.)]
- Gibson C, Dumaine R, Gelfand E, et al. Association of glomerular filtration rate on presentation with subsequent mortality in non-ST-segment elevation acute coronary syndrome: Observations in 13,307 patients in five TIMI trials. Eur Heart J. 2004;25:1998-2005.
- Marenzi G, Assanelli E, Campodonico J, et al. Acute kidney injury in ST-segment elevation acute myocardial infarction complicated by cardiogenic shock at admission. Crit Care Med. 2010;38:438-444.
- Al Suwaidi J, Reddan D, Williams K, et al. Prognostic implications of abnormalities in renal function in patients with acute coronary syndromes. Circulation. 2002;106:974-980.
Supplementary files
