The connection between the clinical picture of myocardial infarction associated with cardiorenal syndrome with NOS3 gene polymorphism and systemic inflammatory response
- Authors: Siverina А.V.1, Skorodumova E.A.1, Kostenko V.A.1, Pivovarova L.P.1, Ariskina O.B.1, Malyshev M.E.1, Skorodumova E.G.1, Rysev A.V.1, Fedorov A.N.1
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Affiliations:
- Saint Petersburg I.I. Dzhanelidze Research Institute of Emergency Medicine
- Issue: Vol 10, No 4 (2018)
- Pages: 15-22
- Section: Original research
- URL: https://journal-vniispk.ru/vszgmu/article/view/10260
- DOI: https://doi.org/10.17816/mechnikov201810415-22
- ID: 10260
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Abstract
Background. At present close attention is paid to the study of genetic mutations and markers of systemic inflammatory response (SIR) in patients with cardiorenal syndrome.
Aim. To evaluate the effect of NOS3 gene t786c polymorphism and SVR on the clinical course of hospital and long-term periods in patients with myocardial infarction (MI) and acute kidney injury (AKI).
Materials and methods. 108 patients treated for MI were examined. All patients were divided into 2 groups: the first — 56 patients with IM and AKI, the second — 52 patients with IM but without AKI.
Results. In patients with MI and AKI, heterozygote and homozygote by allele С with NOS3 gene polymorphism Т786С, as well as leukocytosis and elevated C-reactive protein (CRP) in the blood were significantly more frequently detected. In the hospital period there was a large percentage of relapses of acute coronary syndrome (ACS), which led to high mortality. In the long-term period recurrent ACS and stent thromboses were also significantly more frequent, as well as high mortality rate.
The conclusion. Patients with IM and AKI revealed high frequency of allele C inheritance with polymorphism t786c gene NOS3, which in combination with the induction of SVR, being manifested by leukocytosis and increase in the content of CRP in the blood, was associated with the severity of the clinical picture, both in hospital and in the long-term periods.
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##article.viewOnOriginalSite##About the authors
Аnna V. Siverina
Saint Petersburg I.I. Dzhanelidze Research Institute of Emergency Medicine
Author for correspondence.
Email: Gudkovanna_09@mail.ru
ORCID iD: 0000-0002-6831-2153
SPIN-code: 7817-1246
врач кардиолог отдела неотложной кардиологии и ревматологии
Russian Federation, 3, Budapeshtskaya street, Saint-Petersburg, 192242Elena A. Skorodumova
Saint Petersburg I.I. Dzhanelidze Research Institute of Emergency Medicine
Email: elskor@mail.ru
доктор медицинских наук, старший научный сотрудник отдела неотложной кардиологии и ревматологии
Russian Federation, 3, Budapeshtskaya street, Saint-Petersburg, 192242Viktor A. Kostenko
Saint Petersburg I.I. Dzhanelidze Research Institute of Emergency Medicine
Email: vic2012tor@gmail.com
кандидат медицинских наук, руководитель отдела неотложной кардиологии и ревматологии
Russian Federation, 3, Budapeshtskaya street, Saint-Petersburg, 192242Lyudmila P. Pivovarova
Saint Petersburg I.I. Dzhanelidze Research Institute of Emergency Medicine
Email: pivovaroval@yandex.ru
доктор медицинских наук, руководитель отдела лабораторной диагностики
Russian Federation, 3, Budapeshtskaya street, Saint-Petersburg, 192242Olga B. Ariskina
Saint Petersburg I.I. Dzhanelidze Research Institute of Emergency Medicine
Email: olga.ariskina@mail.ru
кандидат биологических наук, научный сотрудник, отдел лабораторной диагностики
Russian Federation, 3, Budapeshtskaya street, Saint-Petersburg, 192242Mikhail E. Malyshev
Saint Petersburg I.I. Dzhanelidze Research Institute of Emergency Medicine
Email: malyshev1972@yandex.ru
доктор биологических наук, заведующий городской лаборатории иммуногенетики и серодиагностики
Russian Federation, 3, Budapeshtskaya street, Saint-Petersburg, 192242Elizaveta G. Skorodumova
Saint Petersburg I.I. Dzhanelidze Research Institute of Emergency Medicine
Email: lisavetta91@mail.ru
ORCID iD: 0000-0002-4961-5570
SPIN-code: 3403-2138
младший научный сотрудник, отдела неотложной кардиологии и ревматологии
Russian Federation, 3, Budapeshtskaya street, Saint-Petersburg, 192242Alexander V. Rysev
Saint Petersburg I.I. Dzhanelidze Research Institute of Emergency Medicine
Email: 79213221618@yandex.ru
кандидат медицинских наук, доцент, заместитель главного врача по терапии
Russian Federation, 3, Budapeshtskaya street, Saint-Petersburg, 192242Artyom N. Fedorov
Saint Petersburg I.I. Dzhanelidze Research Institute of Emergency Medicine
Email: artem_fedorov@inbox.ru
врач кардиолог, отдела неотложной кардиологии и ревматологии
Russian Federation, 3, Budapeshtskaya street, Saint-Petersburg, 192242References
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