Control of resection margins after neoadjuvant systemic therapy in breast-conserving surgery in breast cancer patients
- Authors: Krivorotko P.V.1, Bondarchuk Y.I.1, Donskih R.V.1, Zhiltsova E.K.1, Amirov N.S.1, Bagnenko S.S.1, Chernaya A.V.1, Pesotskiy R.S.1, Emelyanov A.S.1, Mortada V.V.1, Tabagua T.T.1, Gigolaeva L.P.1, Yerechshenko S.S.1, Komyakhov A.V.1, Nikolaev K.S.1, Zernov K.Y.1, Enaldieva D.A.1, Bessonov A.A.2, Artemyeva A.S.1, Busko E.A.1,3, Semiglazov V.V.1,4, Semiglazova T.Y.1, Semiglazov V.F.1, Belyaev A.M.1,5
-
Affiliations:
- National Medical Research Center of Oncology named after N.N. Petrov
- Leningrad Regional Clinical Oncology Center
- Saint Petersburg State University
- Pavlov First Saint Petersburg State Medical University
- North-Western State Medical University named after I.I. Mechnikov
- Issue: Vol 15, No 1 (2023)
- Pages: 87-95
- Section: Original research
- URL: https://journal-vniispk.ru/vszgmu/article/view/131096
- DOI: https://doi.org/10.17816/mechnikov112609
- ID: 131096
Cite item
Abstract
BACKGROUND: Surgical treatment of breast cancer plays a major role in the combined and complex treatment of patients. The “purity” of the examined edges of the resected breast tissue is the main indicator of the reliability of the breast-conserving surgery and one of the main factors in the development of local recurrence. Neoadjuvant (preoperative) systemic therapy allows evaluating the effectiveness of therapy in vivo and reducing the size of the initial formation, both in locally advanced and resectable forms of breast cancer. The main advantage of this treatment is the ability for surgeons to perform breast-conserving surgery to improve patients quality of life and aesthetic outcomes without compromising disease-free and overall survival.
AIM: To study the clinical and pathological characteristics and analyze of the breast-conserving surgery in patients with breast cancer after neoadjuvant chemotherapy.
MATERIALS AND METHODS: 156 performed breast-conserving surgery after neoadjuvant chemotherapy were analyzed. Breast-conserving resection implied radical removal of the residual tumor node within healthy breast tissues with the achievement of negative resection margins. If pathologists detected stained invasive cells/cancer in situ in a formalin-fixed preparation, a second surgical intervention was performed.
RESULTS: Of the 156 studied anatomical preparations after breast-conserving surgery, a positive margin was found in 4 (2.56%) cases. In 4 patients, positive margin was represented by ductal carcinoma in situ. According to the results of trephine biopsy, no intraductal component was found before neoadjuvant chemotherapy. The greatest length of the ductal carcinoma in situ section is 2.2 mm. In 3 cases, the distance to the stained resection margin of the micropreparation was 1 mm. As a result of repeated pathomorphological examination of pre-cut margins after surgical intervention, cancer in situ was not found.
CONCLUSIONS: The ongoing neoadjuvant systemic therapy for breast cancer with a partial or complete response of the tumor increases the percentage of breast-conserving surgery performed in patients who initially belong to the group of radical mastectomy, but who want to save breast tissue.
Full Text
##article.viewOnOriginalSite##About the authors
Petr V. Krivorotko
National Medical Research Center of Oncology named after N.N. Petrov
Email: dr.krivorotko@mail.ru
ORCID iD: 0000-0002-4898-9159
SPIN-code: 2448-7506
Scopus Author ID: 36600762900
MD, Dr. Sci. (Med.)
Russian Federation, 68 Leningradskaya St., Pesochny, Saint Petersburg, 197758Yana I. Bondarchuk
National Medical Research Center of Oncology named after N.N. Petrov
Email: yana_bondarchuk_2015@mail.ru
ORCID iD: 0000-0002-6442-0106
SPIN-code: 9546-3222
PhD student
Russian Federation, 68 Leningradskaya St., Pesochny, Saint Petersburg, 197758Roman V. Donskih
National Medical Research Center of Oncology named after N.N. Petrov
Email: Rdonskih@rambler.ru
ORCID iD: 0000-0002-9391-5327
SPIN-code: 5111-8211
MD, Cand. Sci. (Med.)
Russian Federation, 68 Leningradskaya St., Pesochny, Saint Petersburg, 197758Elena K. Zhiltsova
National Medical Research Center of Oncology named after N.N. Petrov
Email: ziltsova@yandex.ru
ORCID iD: 0000-0002-2029-4582
SPIN-code: 3045-1704
MD, Cand. Sci. (Med.)
Russian Federation, 68 Leningradskaya St., Pesochny, Saint Petersburg, 197758Nikolay S. Amirov
National Medical Research Center of Oncology named after N.N. Petrov
Email: amirovn17@gmail.com
ORCID iD: 0000-0002-2421-3284
SPIN-code: 7793-4290
PhD student
Russian Federation, 68 Leningradskaya St., Pesochny, Saint Petersburg, 197758Sergey S. Bagnenko
National Medical Research Center of Oncology named after N.N. Petrov
Email: bagnenko_ss@mail.ru
ORCID iD: 0000-0002-4131-6293
SPIN-code: 4389-9374
Scopus Author ID: 57222983473
MD, Dr. Sci. (Med.)
Russian Federation, 68 Leningradskaya St., Pesochny, Saint Petersburg, 197758Antonina V. Chernaya
National Medical Research Center of Oncology named after N.N. Petrov
Email: dr.chernaya@mail.ru
ORCID iD: 0000-0002-7975-3165
SPIN-code: 6498-1419
MD, Cand. Sci. (Med.)
Russian Federation, 68 Leningradskaya St., Pesochny, Saint Petersburg, 197758Roman S. Pesotskiy
National Medical Research Center of Oncology named after N.N. Petrov
Email: shipmeback@gmail.com
ORCID iD: 0000-0002-2573-2211
Russian Federation, 68 Leningradskaya St., Pesochny, Saint Petersburg, 197758
Alexander S. Emelyanov
National Medical Research Center of Oncology named after N.N. Petrov
Email: ae28111992@yandex.ru
ORCID iD: 0000-0002-0528-9937
SPIN-code: 6312-4894
Russian Federation, 68 Leningradskaya St., Pesochny, Saint Petersburg, 197758
Viktoria V. Mortada
National Medical Research Center of Oncology named after N.N. Petrov
Email: vika-gukova@mail.ru
ORCID iD: 0000-0002-1982-5710
SPIN-code: 3871-8774
PhD student
Russian Federation, 68 Leningradskaya St., Pesochny, Saint Petersburg, 197758Tengiz T. Tabagua
National Medical Research Center of Oncology named after N.N. Petrov
Email: tedo8308@mail.ru
ORCID iD: 0000-0003-1471-9473
SPIN-code: 4466-6316
MD, Cand. Sci. (Med.)
Russian Federation, 68 Leningradskaya St., Pesochny, Saint Petersburg, 197758Larisa P. Gigolaeva
National Medical Research Center of Oncology named after N.N. Petrov
Email: gigosha532@gmail.com
ORCID iD: 0000-0001-7654-4336
SPIN-code: 3521-7448
MD, Cand. Sci. (Med.)
Russian Federation, 68 Leningradskaya St., Pesochny, Saint Petersburg, 197758Sergey S. Yerechshenko
National Medical Research Center of Oncology named after N.N. Petrov
Email: dr.ereschenko@gmail.com
ORCID iD: 0000-0002-5090-7001
SPIN-code: 5957-9137
MD, Cand. Sci. (Med.)
Russian Federation, 68 Leningradskaya St., Pesochny, Saint Petersburg, 197758Alexander V. Komyakhov
National Medical Research Center of Oncology named after N.N. Petrov
Email: komyahov@yandex.ru
ORCID iD: 0000-0002-6598-1669
SPIN-code: 8286-4406
MD, Cand. Sci. (Med.)
Russian Federation, 68 Leningradskaya St., Pesochny, Saint Petersburg, 197758Kirill S. Nikolaev
National Medical Research Center of Oncology named after N.N. Petrov
Email: kirill.nikolaev87@gmail.com
ORCID iD: 0000-0003-3377-6369
SPIN-code: 5627-6696
MD, Cand. Sci. (Med.)
Russian Federation, 68 Leningradskaya St., Pesochny, Saint Petersburg, 197758Konstantin Yu. Zernov
National Medical Research Center of Oncology named after N.N. Petrov
Email: konstantin_zernov@hotmail.com
ORCID iD: 0000-0002-2138-3982
SPIN-code: 9186-5705
MD, Cand. Sci. (Med.)
Russian Federation, 68 Leningradskaya St., Pesochny, Saint Petersburg, 197758Diana A. Enaldieva
National Medical Research Center of Oncology named after N.N. Petrov
Email: DIANAENALDIEVA932@gmail.com
ORCID iD: 0000-0002-2773-3111
PhD student
Russian Federation, 68 Leningradskaya St., Pesochny, Saint Petersburg, 197758Alexsander A. Bessonov
Leningrad Regional Clinical Oncology Center
Email: dr.bessonov@gmail.com
ORCID iD: 0000-0002-6649-7641
SPIN-code: 3553-4670
MD, Cand. Sci. (Med.)
Russian Federation, Saint PetersburgAnna S. Artemyeva
National Medical Research Center of Oncology named after N.N. Petrov
Email: oinochoya@gmail.com
ORCID iD: 0000-0002-2948-397X
SPIN-code: 5760-5463
MD, Cand. Sci. (Med.)
Russian Federation, 68 Leningradskaya St., Pesochny, Saint Petersburg, 197758Ekaterina A. Busko
National Medical Research Center of Oncology named after N.N. Petrov; Saint Petersburg State University
Email: Katrn@mail.ru
SPIN-code: 7323-1083
MD, Dr. Sci. (Med.)
Russian Federation, 68 Leningradskaya St., Pesochny, Saint Petersburg, 197758; Saint PetersburgVladislav V. Semiglazov
National Medical Research Center of Oncology named after N.N. Petrov; Pavlov First Saint Petersburg State Medical University
Email: oncology.spbgmu@mail.ru
ORCID iD: 0000-0002-8825-5221
SPIN-code: 6786-9577
Scopus Author ID: 7006310596
MD, Dr. Sci. (Med.)
Russian Federation, 68 Leningradskaya St., Pesochny, Saint Petersburg, 197758; Saint PetersburgTatiana Yu. Semiglazova
National Medical Research Center of Oncology named after N.N. Petrov
Email: tsemiglazova@mail.ru
ORCID iD: 0000-0002-4305-6691
SPIN-code: 9773-3759
Scopus Author ID: 8562948700
MD, Dr. Sci. (Med.)
Russian Federation, 68 Leningradskaya St., Pesochny, Saint Petersburg, 197758Vladimir F. Semiglazov
National Medical Research Center of Oncology named after N.N. Petrov
Email: ssemiglazov@mail.ru
ORCID iD: 0000-0003-0077-9619
SPIN-code: 3874-9539
MD, Dr. Sci. (Med.), Professor, Correspondence Member of the RAS
Russian Federation, 68 Leningradskaya St., Pesochny, Saint Petersburg, 197758Aleksey M. Belyaev
National Medical Research Center of Oncology named after N.N. Petrov; North-Western State Medical University named after I.I. Mechnikov
Author for correspondence.
Email: bam281060@yandex.ru
ORCID iD: 0000-0001-5580-4821
SPIN-code: 9445-9473
MD, Dr. Sci. (Med.), Professor
Russian Federation, 68 Leningradskaya St., Pesochny, Saint Petersburg, 197758; Saint PetersburgReferences
- Fisher B, Anderson S, Bryant J, et al. Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer. N Engl J Med. 2002;347(16):1233–1241. doi: 10.1056/NEJMoa022152
- Veronesi U, Cascinelli N, Mariani L, et al. Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer. N Engl J Med. 2002;347(16):1227–1232. doi: 10.1056/NEJMoa020989
- Zikiryakhodzhaev AD, Ermoshchenkova MV, Volchenko NN, et al. Resection margin status during organ-sparing surgery for breast cancer. P.A. Herzen Journal of Oncology. 2015;4(6):65–73. (In Russ.) doi: 10.17116/onkolog20154665-73
- Semiglazov VF, Semiglazov VV, Nikolaev KS, et al. The control of surgical margins for organ-preserving treatment of breast cancer. Cancer Surgery. 2014;(1):58–63. (In Russ.)
- Boughey JC, Peintinger F, Meric-Bernstam F, et al. Impact of preoperative versus postoperative chemotherapy on the extent and number of surgical procedures in patients treated in randomized clinical trials for breast cancer. Ann Surg. 2006;244(3):464–470. doi: 10.1097/01.sla.0000234897.38950.5c
- Volders JH, Negenborn VL, Spronk PE, et al. Breast-conserving surgery following neoadjuvant therapy-a systematic review on surgical outcomes. Breast Cancer Res Treat. 2018;168(1):1–12. doi: 10.1007/s10549-017-4598-5
- Curigliano G, Burstein HJ, Winer EP, et al. De-escalating and escalating treatments for early-stage breast cancer: the St. Gallen International Expert Consensus Conference on the Primary Therapy of Early Breast Cancer 2017. Ann Oncol. 2017;28(8):1700–1712. doi: 10.1093/annonc/mdx308
- Volders JH, Haloua MH, Krekel NM, et al. Neoadjuvant chemotherapy in breast-conserving surgery – Consequences on margin status and excision volumes: A nationwide pathology study. Eur J Surg Oncol. 2016;42(7):986–993. doi: 10.1016/j.ejso.2016.02.252
- Wang SY, Chu H, Shamliyan T, et al. Network meta-analysis of margin threshold for women with ductal carcinoma in situ. J Natl Cancer Inst. 2012;104(7):507–516. doi: 10.1093/jnci/djs142
- Gobardhan PD, de Wall LL, van der Laan L, et al. The role of radioactive iodine-125 seed localization in breast-conserving therapy following neoadjuvant chemotherapy. Ann Oncol. 2013;24(3):668–673. doi: 10.1093/annonc/mds475
- Rubio IT, Esgueva-Colmenarejo A, Espinosa-Bravo M, et al. Intraoperative ultrasound-guided lumpectomy versus mammographic wire localization for breast cancer patients after neoadjuvant treatment. Ann Surg Oncol. 2016;23(1):38–43. doi: 10.1245/s10434-015-4935-z
- Haque W, Verma V, Hatch S, et al. Response rates and pathologic complete response by breast cancer molecular subtype following neoadjuvant chemotherapy. Breast Cancer Res Treat. 2018;170(3):559–567. doi: 10.1007/s10549-018-4801-3
- Chen AM, Meric-Bernstam F, Hunt KK, et al. Breast conservation after neoadjuvant chemotherapy: the MD Anderson cancer center experience. J Clin Oncol. 2004;22(12):2303–2312. doi: 10.1200/JCO.2004.09.062
- Brouwer de Koning SG, Vrancken Peeters MTFD, Jóźwiak K, et al. Tumor resection margin definitions in breast-conserving surgery: Systematic review and meta-analysis of the current literature. Clin Breast Cancer. 2018;18(4):e595–e600. doi: 10.1016/j.clbc.2018.04.004
- Muttalib M, Tisdall M, Scawn R, et al. Intra-operative specimen analysis using faxitron microradiography for excision of mammographically suspicious, non-palpable breast lesions. Breast. 2004;13(4):307–315. doi: 10.1016/j.breast.2004.02.005
Supplementary files
