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Post a Comment Natriuretic response to hypervolemia and injection of diuretics in patients with chronic heart failure
- Authors: Frolov D.S.1, Shustov S.B.1, Sveklina T.S.1, Sardinov R.T.1, Saluhov V.V.1
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Affiliations:
- S.M. Kirov Military Medical Academy
- Issue: Vol 12, No 2 (2020)
- Pages: 39-44
- Section: Original research
- URL: https://journal-vniispk.ru/vszgmu/article/view/34089
- DOI: https://doi.org/10.17816/mechnikov202012239-44
- ID: 34089
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Abstract
Relevance. The article analyze the results of changes in the diuretic and natriuretic response to standard hypervolemic load and the injection of a diuretic in patients with chronic heart failure with preserved and reduced left ventricular ejection fraction.
Purpose. Evaluation of changes in the natriuretic response to hypervolemia and diuretic injection in patients with chronic heart failure.
Materials and methods. 25 men with chronic heart failure were examined; the average age was 68 y. o. (67; 73). Of these, 13 patients with chronic heart failure and a left ventricular ejection fraction (LVEF) of less than 50 % entered the first studied group and 12 patients with chronic heart failure with preserved LVEF (more than 50%), who entered the second studied group. In all the patients, hypervolemia was induced by Ringer’s solution, followed by the injection of furosemide and the registration of diuresis and natriuresis.
Results. When analyzing natriuresis in the studied patients, it was found that at the same concentration of serum sodium, there is a multidirectional reaction to the excretion of sodium in the urine in both groups. At the same time, the rates of diuresis in both groups did not differ significantly.
Conclusion. Thus, with chronic heart failure and reduced LVF less than 50% patients had a lower natriuresis compared to those studied with preserved LVF. In the patients with chronic heart failure fluid overload on the mixed response it is noted that if the urine sodium level is at the lower limit of normal in patients with reduced LVF less than 50%, then, against the background of stimulation of diuresis, sodium begins to be excreted more intensively. In the patients with chronic heart failure with preserved LVF, the urine sodium level is at the upper limit of the norm and when furosemide is stimulated, there is a decrease in its excretion.
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##article.viewOnOriginalSite##About the authors
Dmitrij S. Frolov
S.M. Kirov Military Medical Academy
Author for correspondence.
Email: froloff_82@mail.ru
SPIN-code: 4089-0078
кандидат медицинских наук, преподаватель
Russian Federation, Saint PetersburgSergej B. Shustov
S.M. Kirov Military Medical Academy
Email: sbs5555@mail.ru
профессор 1 кафедры (терапии усовершенствования врачей) доктор медицинских наук, профессор, Заслуженный врач Российской Федерации
Russian Federation, Saint PetersburgTatyana S. Sveklina
S.M. Kirov Military Medical Academy
Email: sveklinats@mail.ru
кандидат медицинских наук, преподаватель
Russian Federation, Saint PetersburgRuslan T. Sardinov
S.M. Kirov Military Medical Academy
Email: 9117032134@mail.ru
кандидат медицинских наук, преподаватель
Russian Federation, Saint PetersburgVladimir V. Saluhov
S.M. Kirov Military Medical Academy
Email: vlasaluk@yandex.ru
начальник 1 кафедры (терапии усовершенствования врачей) ФГБВОУ ВО «Военно-медицинская академия имени С.М. Кирова» МО РФ, доктор медицинских наук, доцент
Russian Federation, Saint PetersburgReferences
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