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Post a Comment Cutaneous manifestations of ANCA-associated vasculitis and immunosuppressive therapy: cause-effect relationships (a case report)
- Authors: Kitova M.A.1, Maksimov M.V.2, Marchenko V.N.2, Bruchkus E.A.2, Davydov D.A.2
-
Affiliations:
- Municipal Out-Patient Department No 93
- Pavlov University
- Issue: Vol 12, No 3 (2020)
- Pages: 79-84
- Section: Case report
- URL: https://journal-vniispk.ru/vszgmu/article/view/35175
- DOI: https://doi.org/10.17816/mechnikov35175
- ID: 35175
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Abstract
Granulomatosis with polyangiitis, formerly known as Wegener’s granulomatosis, is an autoimmune ANCA-associated systemic vasculitis characterized by extensive damage to multiple organs and systems. Besides a typical clinical triad of ENT, lungs, and kidneys injury, various types of skin lesions can be found in 10–50% of cases. A severe course of the disease and low survival of patients often requires using aggressive treatment in a form of combined immunosuppressive therapy. On the one hand, it generally improves the prognosis, and on the other is itself associated with numerous complications. One of them is a secondary infection. Skin is the second most common localization of infection after the respiratory system. Preceding skin lesions caused by vasculitis may increase the risk of infection. Thus, patients with ANCA-associated vasculitis should be carefully observed for cutaneous manifestation, both before and during the immunosuppressive therapy.
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##article.viewOnOriginalSite##About the authors
Madina A. Kitova
Municipal Out-Patient Department No 93
Email: madina8141@mail.ru
rheumatologist, Municipal out-patient department №93
Russian Federation, Saint PetersburgMaksim V. Maksimov
Pavlov University
Email: bolec@sampo.ru
PhD (Medicine), associate professor, Hospital Therapy Department
Russian Federation, Saint Petersburg
Valeriy N. Marchenko
Pavlov University
Email: marchvn@mail.ru
ORCID iD: 0000-0002-2440-7222
SPIN-code: 1711-4150
Scopus Author ID: 57206419660
PhD (Medicine), Professor, Hospital Therapy Department
Russian Federation, Saint PetersburgElena A. Bruchkus
Pavlov University
Email: bruklen@listl.ru
Head of the Second Cardiology Department, Scientific Research Institute of Rheumatology and Allergology of the Scientific and Clinical Research Center
Russian Federation, Saint PetersburgDenis A. Davydov
Pavlov University
Author for correspondence.
Email: davydov.rheum@gmail.com
ORCID iD: 0000-0002-5524-1616
SPIN-code: 1132-5294
Scopus Author ID: 57217159189
resident, Hospital Therapy Department
Russian Federation, Saint PetersburgReferences
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