DYNAMICS OF CYTOKINS AND THEIR INTERRELATION IN LIVER CIRRHOSIS


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Abstract

The research objectives are to determine serum interleukins (IL-2, IL-6) and tumor necrosis factor alpha (TNF - α) and evaluate their interrelation in liver cirrhosis (class A, B, C according to Chad - Pugh). 117 patients were examined and their cytokines levels were determined using enzyme-linked immunosorbent assay.Elevation of cytokine levels IL-2, I-6 and TNF-α within reference values was found in liver cirrhosis cases, expect for level IL-6 in liver cirrhosis cases of class C. In these cases IL-6 level exceeds reference values and is within the limit of 9,94 - 25,21 pg / ml with average concentration of 14,89±4,96 pg / ml. Correlation is found between TNF- α and IL-6 (r = - 0,499) in liver cirrhosis of class A and correlation between TNF- α and IL-2 (r = 0,421) is found in liver cirrhosis of class B.

About the authors

B B Fishman

Novgorod State University named after Yaroslav the Wise, Velikiy Novgorod, Russia

M A Toneeva

Novgorod State University named after Yaroslav the Wise, Velikiy Novgorod, Russia

V E Kulikov

Novgorod State University named after Yaroslav the Wise, Velikiy Novgorod, Russia

V A Kornilova

Novgorod State University named after Yaroslav the Wise, Velikiy Novgorod, Russia

E R Antonova

Novgorod State University named after Yaroslav the Wise, Velikiy Novgorod, Russia

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Copyright (c) 2015 Fishman B.B., Toneeva M.A., Kulikov V.E., Kornilova V.A., Antonova E.R.

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