CLINICAL AND IMMUNOLOGICAL CORRELATIONS IN PATIENTS WITH SYSTEMICLUPUS ERYTHEMATOSUS WITH ANTIPHOSPHOLIPID ANTIBODY SYNDROME

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Abstract

Antiphospholipid antibodies (aPL): lupus anticoagulant (LA), anticardiolipin antibodies (aCL) and anti-β2-glycoprotein I antibodies (anti-β2GPI) are found in 12 to 44% of systemic lupus erythematosus (SLE) patients. On average, antiphospholipid antibody syndrome (APS) develops in50% of aPL-positive patients with SLE. The seronegative APS is characterized by the absence of the diagnostic levels of "classical" aPL and by the presence of non-criteria aPL: antibodies against pro- thrombin (aPT), antibodies against annexin V, antibodies against phosphatidylethanoamine (aPE), antibodies to phosphatidylserine/prothrombin complex (aPS-PT) and antibodies against negatively charged phospholipids. The presence of four antibodies (LA + aCT + anti-β2GPI + aPT) is associated with a threefold increase in the risk of thrombosis. The presence of aCL and anti-β2GPI in SLE patients with APS and recurrent thromboses is associated with the HLA dRB1 * 0402.

About the authors

E A Belolipetskaia

North-Western State Medical university named after I.I. Mechnikov

I B Beliaeva

North-Western State Medical university named after I.I. Mechnikov

V I Mazurov

North-Western State Medical university named after I.I. Mechnikov

E A Trofimov

North-Western State Medical university named after I.I. Mechnikov

S V Lapin

St. Petersburg State Medical university named after I.P. Pavlov

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Copyright (c) 2017 Belolipetskaia E.A., Beliaeva I.B., Mazurov V.I., Trofimov E.A., Lapin S.V.

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