Fever-induced epileptic encephalopathy in children (FIRES)

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Abstract

Fever infection-related epilepticy syndrome, FIRES — rare severe epileptic encephalopathy infection or fever-induced refractory epileptic status developing in a previously healthy child. The etiology of FIRES remains unknown; post-inflammatory and autoimmune mechanisms are assumed. Recovery is possible, but the majority of children develop significant cognitive failure and refractory epilepsy.

About the authors

Ludmila M. Sсhugareva

Children’s Hospital No. 1; North-Western State Medical University named after I.I. Mechnikov

Email: neurodoctor@mail.ru

доктор медицинских наук, профессор кафедры детской невропатологии и нейрохирургии СЗГМУ им. И.И. Мечникова, заведующая отделением неврологии СПб ГБУЗ ДГБ 1

Russian Federation, 14, Avangardnaya str., St. Petersburg, 198205;41, Kirochnaya street, Saint-Petersburg, 191015

Oksana V. Poteshkina

Children’s Hospital No. 1; North-Western State Medical University named after I.I. Mechnikov

Author for correspondence.
Email: ovpoteshkina@gmail.com
SPIN-code: 9407-5169

кандидат медицинских наук, доцент кафедры детской невропатологии и нейрохирургии СЗГМУ им. И.И. Мечникова, врач – невролог СПб ГБУЗ ДГБ 1

Russian Federation, 14, Avangardnaya str., St. Petersburg, 198205; 41, Kirochnaya street, Saint-Petersburg, 191015

Marina K. Kruchina

Children’s Hospital No. 1

Email: mkk68@mail.ru

Зам. главного врача по медицинской части СПб ГБУЗ ДГБ 1

Russian Federation, 14, Avangardnaya str., St. Petersburg, 198205

Mikhail A. Rusak

Children’s Hospital No. 1

Email: rusakneo@gmail.com

Заведующий отделением общей реанимации СПб ГБУЗ ДГБ 1

Russian Federation, 14, Avangardnaya str., St. Petersburg, 198205

References

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2. Fig. 1. Patient, 4 y. o. Diagnosis: FIRES: а — axial fluid attenuated inversion recovery image on day 1 of hospitalization shows no abnormalities; b — axial fluid attenuated inversion recovery image on day 30 of hospitalization — widening of sulci and lateral ventricles suggestive of diffuse cerebral atrophy, hyperintense signal changes are seen in bilateral thalami as well as along the ependymal margins of the ventricles and peri-atrial regions (J Perumpillichira. 2014)

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3. Fig. 2. Patient S.K., 15 y. о. Diagnosis: FIRES: a — EEG (1 day of the disease) — diffuse disorganization of rhythm beta activity; b — EEG (day 5 of the disease) — a diffuse slowing of the background activity, in the right frontal-temporal region sharp-and-slow wave epileptiform activity are registered; c — EEG before discharge (day 20 of the disease) — the improvement of the background activity, moderate slowing of the background activity, no epileptiform activity recorded. Own observation

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4. Fig. 3. Temperature sheet. Hectic type of fever

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Copyright (c) 2019 Sсhugareva L.M., Poteshkina O.V., Kruchina M.K., Rusak M.A.

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