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发表评论 新冠病毒感染的临床病程、治疗效果和疗效：初步分析
- 作者: Sayganov S.A.1, Mazurov V.I.1, Bakulin I.G.1, Lataria E.L.1, Artyushkin SA1, Chizhova O.Y.1, Ruslyakova I.A.1, Prokofieva N.A.1, Fil T.S.1, Tsurtsumiya D.B.1, Tikhonov S.V.1, Skalinskaya M.I.1, Rasmagina I.A.1, Alieva M.K.1, Trofimov EA1, Bakulina N.V.1, Kolmakova E.V.1, Sheyko A.D.1, Belousova L.N.1
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隶属关系:
- North-Western State Medical University named after I.I. Mechnikov
- 期: 卷 12, 编号 2 (2020)
- 页面: 27-38
- 栏目: Original research
- URL: https://journal-vniispk.ru/vszgmu/article/view/34932
- DOI: https://doi.org/10.17816/mechnikov202012227-38
- ID: 34932
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详细
研究现实性。为了核实新的冠状病毒感染（COVID-19），有必要根据临床、实验室和仪器数据，
制定明确的诊断和治疗患者的算法，在某些情况下，要及时做出明智的决定，优化管理策略，
并开出主动的抗炎治疗处方，直到有一个完整的危及生命的临床情况出现。
本研究的目的是分析新冠病毒感染的病程和结果取决于患者的初始特征和治疗方案。
材料与方法。采用随机抽样的方法，对North-Western State Medical University named after Mechnikov新冠病毒感染治疗中心收治的129人的病史进行了初步分析。住院患者中，男性为67例
（51.9%），平均年龄为57.9±16.4岁；女性为62例（48.1%），平均年龄为60.2±13.6岁。
所有患者均接受标准的临床、实验室和仪器检查，测定饱和指标（SpO2）、细胞因子风暴标志物
（C-反应蛋白、铁蛋白、天冬氨酸转氨酶、d二聚体、纤维蛋白原、淋巴细胞）含量，并行肺CT扫描。治疗的有效性和安全性通过结果（康复、死亡）以及治疗期间不良事件的存在来评估。使用Statistica 12 for Windows软件包对研究结果进行统计处理。用学生的t标准（t > 2，
p < 0.05）评估两个相对值之间的信度。
结果。死亡结果在老年和男性患者中明显较多。在入院的患者中，伴随疾病如肥胖、糖尿病和心血管疾病的存在与更频繁的死亡有关，这使得我们认为共病是COVID-19严重病程和不良预后的一个危险因素。但是，一般来说，无法确定COVID-19患者和这些共病形式与无共病患者的预后有显著差异，这可能是由于患者样本不足所致。
不良结局的预测因素有低饱和值、呼吸衰竭、入院时肺组织明显损伤（CT-3-4），以及C-反应蛋白、铁蛋白、天冬氨酸转氨酶、d二聚体、中性粒细胞增多、淋巴细胞减少和血小板减少高值。
在综合治疗中使用抗细胞因子药物可以被认为是预后的良好预测因子。通过这些研究资料，我们不仅可以对COVID-19共病患者使用抗细胞因子药物进行复杂治疗的病程特征和疗效进行预评估，而且可以开发治疗和诊断算法。
作者简介
Sergey Sayganov
North-Western State Medical University named after I.I. Mechnikov
Email: sergey.sayganov@szgmu.ru
ORCID iD: 0000-0001-8325-1937
Scopus 作者 ID: 56512453000
professor, MD, PhD, Head of the Chair of Hospital Therapy and Cardiology n.a. M.S. Kushakovsky, rector of "North-West State Medical University n.a. I.I. Mechnikov" Ministry of Health of Russia, Saint Petersburg, Russia
俄罗斯联邦, 191015, Saint-Petersburg, Kirochnaya street, 41Vadim Mazurov
North-Western State Medical University named after I.I. Mechnikov
Email: maz.nwgmu@yandex.ru
ORCID iD: 0000-0002-0797-2051
D. Sci. (Med.), Prof., RAS academician, Head of the research institute of Rheumatology North-Western State Medical University named after I.I. Mechnikov, head of Department of Therapy, Rheumatology, Examination of Temporary Disability and Quality of Medical Care named after E.E.Eichwald FSBEI HE North-Western State Medical University named after I. I. Mechnikov
俄罗斯联邦, 191015, Saint-Petersburg, Kirochnaya street, 41Igor Bakulin
North-Western State Medical University named after I.I. Mechnikov
Email: igbakulin@yandex.ru
ORCID iD: 0000-0002-6151-2021
SPIN 代码: 5283-2032
Scopus 作者 ID: 6603812937
Researcher ID: P-4453-2014
Dean of the medical faculty, Professor, doctor of medical Sciences, head of the Department of propaedeutics of internal diseases of gastroenterology and dietetics named after S. M. Rys
俄罗斯联邦, 191015, Saint-Petersburg, Kirochnaya street, 41Elguja Lataria
North-Western State Medical University named after I.I. Mechnikov
Email: Elguja.Lataria@szgmu.ru
MD, PhD, associate Professor, Vice-Rector for Clinical Work, Head Doctor of Clinics North-West State Medical University named after I.I. Mechnikov "Ministry of Health of Russia, Saint Petersburg, Russia
俄罗斯联邦, 191015, Saint-Petersburg, Kirochnaya street, 41S Artyushkin
North-Western State Medical University named after I.I. Mechnikov
Email: Sergei.Artyushkin@szgmu.ru
ORCID iD: 0000-0003-4482-6157
Vice Rector for Academic Affairs of North-Western
State Medical University named after I.I.Mechnikov,
Saint Petersburg, Russia 俄罗斯联邦, 191015, Saint-Petersburg, Kirochnaya street, 41
Olga Chizhova
North-Western State Medical University named after I.I. Mechnikov
Email: Ochizhova@gmail.com
ORCID iD: 0000-0002-1716-7654
MD, PhD, Professor of the Chair of the Propedeutics of Internal Diseases, Gastroenterology and Dietology n.a. S.M. Ryss North-Western State Medical University n.a. I.I. Mechnikov, Saint Petersburg, Russia
俄罗斯联邦, 191015, Saint-Petersburg, Kirochnaya street, 41Irina Ruslyakova
North-Western State Medical University named after I.I. Mechnikov
Email: Irina.Ruslyakova@szgmu.ru
ORCID iD: 0000-0003-1507-833X
MD, PhD, assistant of the Chair of propaedeutics of internal diseases, gastroenterology and dietetics n.a. S.M. Ryss North-Western State Medical University n.a. I.I. Mechnikov, anesthetist-resuscitator, head of the intensive care unit for the patients of the therapeutic profile of the Clinic North-Western State Medical University n.a. I.I. Mechnikov, Saint Petersburg, Russia
俄罗斯联邦, 191015, Saint-Petersburg, Kirochnaya street, 41Natalia Prokofieva
North-Western State Medical University named after I.I. Mechnikov
Email: Natalya.Prokofeva@szgmu.ru
ORCID iD: 0000-0003-3105-4530
Head of the therapeutic department of the Clinic North-Western State Medical University n.a. I.I. Mechnikov, Saint Petersburg, Russia
俄罗斯联邦, 191015, Saint-Petersburg, Kirochnaya street, 41Tatiana Fil
North-Western State Medical University named after I.I. Mechnikov
Email: Tatyana.Fil@szgmu.ru
ORCID iD: 0000-0002-2859-4942
MD, PhD, Head of the gastroenterological department of the Clinic North-Western State Medical University n.a. I.I. Mechnikov, Saint Petersburg, Russia
俄罗斯联邦, 191015, Saint-Petersburg, Kirochnaya street, 41Daridzhan Tsurtsumiya
North-Western State Medical University named after I.I. Mechnikov
Email: D.Tcurtcumiya@szgmu.ru
ORCID iD: 0000-0001-7806-9364
MD, PhD, associate Professor of the Chair of Internal Medicine, Clinical Pharmacology and Nephrology North-Western State Medical University n.a. I.I. Mechnikov, Saint Petersburg, Russia
俄罗斯联邦, 191015, Saint-Petersburg, Kirochnaya street, 41Sergey Tikhonov
North-Western State Medical University named after I.I. Mechnikov
Email: sergeyvt2702@gmail.com
ORCID iD: 0000-0001-5720-3528
SPIN 代码: 6921-5511
MD, PhD, associate Professor of the Chair of Internal Medicine, Clinical Pharmacology and Nephrology North-Western State Medical University n.a. I.I. Mechnikov
俄罗斯联邦, 191015, Saint-Petersburg, Kirochnaya street, 41Mariya Skalinskaya
North-Western State Medical University named after I.I. Mechnikov
编辑信件的主要联系方式.
Email: mskalinskaya@yahoo.com
ORCID iD: 0000-0003-0769-8176
Associate proffessor of the Chair of the Propedeutics of Internal Diseases, PhD Gastroenterology and Dietology n.a. S.M. Riss
俄罗斯联邦, 191015, Saint-Petersburg, Kirochnaya street, 41Irina Rasmagina
North-Western State Medical University named after I.I. Mechnikov
Email: irenerasmagina@gmail.com
ORCID iD: 0000-0003-3525-3289
resident of the Chair of the Propedeutics of Internal Diseases, Gastroenterology and Dietology n.a. S.M. Riss North-Western State Medical University n.a.I.I.Mechnikov, Saint Petersburg, Russia
俄罗斯联邦, 191015, Saint-Petersburg, Kirochnaya street, 41Marianna Alieva
North-Western State Medical University named after I.I. Mechnikov
Email: diezirrhose@gmail.com
ORCID iD: 0000-0002-0763-6111
resident of the Chair of the Propedeutics of Internal Diseases, Gastroenterology and Dietology n.a. S.M. Riss North-Western State Medical University n.a.I.I.Mechnikov, Saint Petersburg, Russia
俄罗斯联邦, 191015, Saint-Petersburg, Kirochnaya street, 41E Trofimov
North-Western State Medical University named after I.I. Mechnikov
Email: trofimov-zeka@mail.ru
ORCID iD: 0000-0003-3236-4485
associate professor, MD, PhD, associate professor of the Сhair of therapy, rheumatology, examination of temporary disability and quality of medical care n.a. E. E. Eichwald North-Western State Medical University n.a. I.I. Mechnikov.
俄罗斯联邦, 191015, Saint-Petersburg, Kirochnaya street, 41Nataliay Bakulina
North-Western State Medical University named after I.I. Mechnikov
Email: nv_bakulina@mail.ru
ORCID iD: 0000-0003-4075-4096
Scopus 作者 ID: 7201739080
Researcher ID: N-7299-2014
http://www.researcherid.com/rid/N-7299-2014
professor, MD, PhD, Head of the Chair of Internal Medicine, Clinical Pharmacology and Nephrology North-Western State Medical University n.a. I.I. Mechnikov, Saint Petersburg, Russia
俄罗斯联邦, 191015, Saint-Petersburg, Kirochnaya street, 41Elena Kolmakova
North-Western State Medical University named after I.I. Mechnikov
Email: Elena.Kolmakova@szgmu.ru
ORCID iD: 0000-0002-3438-5004
MD, PhD, associate Professor of the Chair of Internal Medicine, Clinical Pharmacology and Nephrology North-Western State Medical University n.a. I.I. Mechnikov, Saint Petersburg, Russia
俄罗斯联邦, 191015, Saint-Petersburg, Kirochnaya street, 41Anna Sheyko
North-Western State Medical University named after I.I. Mechnikov
Email: knopfchenanka@gmail.com
ORCID iD: 0000-0002-1677-433X
student
俄罗斯联邦, 191015, Saint-Petersburg, Kirochnaya street, 41Lia Belousova
North-Western State Medical University named after I.I. Mechnikov
Email: liya-belousova@yandex.ru
ORCID iD: 0000-0003-4778-1767
MD, PhD, associate professor of the Chair of the Propedeutics of Internal Diseases, Gastroenterology and Dietology n.a. S.M. Riss North-Western State Medical University n.a.I.I.Mechnikov, Saint Petersburg, Russia
俄罗斯联邦, 191015, Saint-Petersburg, Kirochnaya street, 41参考
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