Physicochemical Properties and Biological Activity of the Peptide–Protein Complex from Bovine Scleral Tissue
- Authors: Sidorskii E.V.1, Il’ina A.P.1, Krasnova M.S.1, Yamskova V.P.2, Buryak A.K.3, Yamskov I.A.1
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Affiliations:
- Nesmeyanov Institute of Organoelement Compounds
- Koltzov Institute of Developmental Biology
- Frumkin Institute of Physical Chemistry and Electrochemistry
- Issue: Vol 54, No 1 (2018)
- Pages: 83-88
- Section: Article
- URL: https://journal-vniispk.ru/0003-6838/article/view/152415
- DOI: https://doi.org/10.1134/S000368381801012X
- ID: 152415
Cite item
Abstract
The peptide–protein complex from bovine sclera was studied. It is shown that it contained a protein with a molecular weight of 66387 Da with the partial N-terminal amino acid sequence DTHKSEIAHRFKDLG-, which is homologous to the mature molecule of bovine serum albumin, and polypeptides with molecular weights of 1300–5080 Da. With a model of the organotypic cultivation of posterior eye tissues of the newt Pleurodeles waltl in vitro, it was shown that the effect of this peptide–protein complex in low doses increased the viability of scleral fibroblasts.
Keywords
About the authors
E. V. Sidorskii
Nesmeyanov Institute of Organoelement Compounds
Email: Yamskov@mail.ru
Russian Federation, Moscow, 119334
A. P. Il’ina
Nesmeyanov Institute of Organoelement Compounds
Email: Yamskov@mail.ru
Russian Federation, Moscow, 119334
M. S. Krasnova
Nesmeyanov Institute of Organoelement Compounds
Email: Yamskov@mail.ru
Russian Federation, Moscow, 119334
V. P. Yamskova
Koltzov Institute of Developmental Biology
Email: Yamskov@mail.ru
Russian Federation, Moscow, 119334
A. K. Buryak
Frumkin Institute of Physical Chemistry and Electrochemistry
Email: Yamskov@mail.ru
Russian Federation, Moscow, 119071
I. A. Yamskov
Nesmeyanov Institute of Organoelement Compounds
Author for correspondence.
Email: Yamskov@mail.ru
Russian Federation, Moscow, 119334
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