Physicochemical Properties and Biological Activity of the Peptide–Protein Complex from Bovine Scleral Tissue


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Abstract

The peptide–protein complex from bovine sclera was studied. It is shown that it contained a protein with a molecular weight of 66387 Da with the partial N-terminal amino acid sequence DTHKSEIAHRFKDLG-, which is homologous to the mature molecule of bovine serum albumin, and polypeptides with molecular weights of 1300–5080 Da. With a model of the organotypic cultivation of posterior eye tissues of the newt Pleurodeles waltl in vitro, it was shown that the effect of this peptide–protein complex in low doses increased the viability of scleral fibroblasts.

About the authors

E. V. Sidorskii

Nesmeyanov Institute of Organoelement Compounds

Email: Yamskov@mail.ru
Russian Federation, Moscow, 119334

A. P. Il’ina

Nesmeyanov Institute of Organoelement Compounds

Email: Yamskov@mail.ru
Russian Federation, Moscow, 119334

M. S. Krasnova

Nesmeyanov Institute of Organoelement Compounds

Email: Yamskov@mail.ru
Russian Federation, Moscow, 119334

V. P. Yamskova

Koltzov Institute of Developmental Biology

Email: Yamskov@mail.ru
Russian Federation, Moscow, 119334

A. K. Buryak

Frumkin Institute of Physical Chemistry and Electrochemistry

Email: Yamskov@mail.ru
Russian Federation, Moscow, 119071

I. A. Yamskov

Nesmeyanov Institute of Organoelement Compounds

Author for correspondence.
Email: Yamskov@mail.ru
Russian Federation, Moscow, 119334

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