Chitosan-Based Mucoadhesive Systems for the Inclusion of the Echinochrome Active Substance

Abstract

Polyelectrolyte complexes (PECs) of chitosan (CH) with kappa/beta carrageenan (κ/β-K), a polysaccharide of red algae, were obtained in a soluble form and as films. Using porcine intestinal mucosa as a model, it was shown that single-layer films obtained from polysaccharides and a three-layer film containing their polyelectrolyte complex exhibited mucoadhesive properties. The mucoadhesive ability of the films depended on the polysaccharide type and changed after PEC formation. Comparative analysis of the ζ-potential values determined for the soluble form of polyelectrolyte complexes in an aqueous solution and in a mucin-containing solution confirmed the mucoadhesive properties of the PECs. It was found that the complexes retained their mucoadhesive properties upon the inclusion of echinochrome A in their soluble form. This made it possible to consider them noninvasive forms of drug delivery.