Email this article Hormonal regulation of NK cell cytotoxic activity
- Authors: Shirshev S.V.1, Nekrasova I.V.1, Gorbunova O.L.1, Orlova E.G.1
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Affiliations:
- Institute of Ecology and Genetics of Microorganisms, Ural Division
- Issue: Vol 472, No 1 (2017)
- Pages: 28-30
- Section: Cell Biology
- URL: https://journal-vniispk.ru/0012-4966/article/view/153978
- DOI: https://doi.org/10.1134/S0012496617010021
- ID: 153978
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Abstract
The effects of chorionic gonadotropin, estriol (E3), leptin, ghrelin, and kisspeptin on the intracellular expression of perforin, granzyme A, and granzyme B was studied in separated NK cells. All studied hormones except E3 are could modulate the expression of cytotoxic enzymes in NK cells by suppression of the expression of the most active proapoptotic agents, resulting in increased expression of granzyme A, which is typical of the decidual subpopulation of these lymphocytes.
About the authors
S. V. Shirshev
Institute of Ecology and Genetics of Microorganisms, Ural Division
Author for correspondence.
Email: shirshev@iegm.ru
Russian Federation, Perm, 614081
I. V. Nekrasova
Institute of Ecology and Genetics of Microorganisms, Ural Division
Email: shirshev@iegm.ru
Russian Federation, Perm, 614081
O. L. Gorbunova
Institute of Ecology and Genetics of Microorganisms, Ural Division
Email: shirshev@iegm.ru
Russian Federation, Perm, 614081
E. G. Orlova
Institute of Ecology and Genetics of Microorganisms, Ural Division
Email: shirshev@iegm.ru
Russian Federation, Perm, 614081
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